Next Article in Journal
Abundance and Distribution of Phlebotomus pedifer (Diptera: Psychodidae) Across Various Habitat Types in Endemic Foci of Cutaneous Leishmaniasis in the Mid-Highlands of Wolaita Zone, Southern Ethiopia
Previous Article in Journal
Snakebites in Cameroon by Species Whose Effects Are Poorly Described
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
TropicalMed
Volume 9
Issue 12
10.3390/tropicalmed9120301
tropicalmed-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Acceptance and Completion Rates of 3-Month Isoniazid-Rifampicin (3HR) Tuberculosis Preventive Treatment (TPT) Among Contacts of Bacteriologically Confirmed TB Patients—Patients’ and Healthcare Workers’ Perspectives

by
Austin Ihesie
1,
Ogoamaka Chukwuogo
2,
Rupert Eneogu
1,
Olugbenga Kayode Daniel
3,
Aderonke Agbaje
3,
Bethrand Odume
2,
Debby Nongo
1,
Charles Ohikhuai
4,
Nera Kadiri-Eneh
2,
Omosalewa Oyelaran
1,
Victor Obianeri
1,
Wayne Van Gemert
5,
Enos Okumu Masini
5,
Cleophas D’auvergne
6,
Urhioke Ochuko
7,
Chukwuma Anyaike
7 and
Sunday Olakunle Olarewaju
8,*
1
United States Agency for International Development, Central Business District, Abuja 900211, Nigeria
2
KNCV Nigeria, Central Business District, Abuja 900211, Nigeria
3
Institute of Human Virology Nigeria (IHVN), IHVN Towers, C00 Emeritus Umaru Shehu Ave, Cadastral, Abuja 900108, Nigeria
4
Viamo Technologies Limited, Abuja 900108, Nigeria
5
Stop TB Partnership, 1218 Geneva, Switzerland
6
United States Agency for International Development Global Health Bureau, Washington, DC 20004, USA
7
Federal Ministry of Health, Abuja 900108, Nigeria
8
Department of Community Medicine, Osun State University, Osogbo 230101, Nigeria
*
Author to whom correspondence should be addressed.
Trop. Med. Infect. Dis. 2024, 9(12), 301; https://doi.org/10.3390/tropicalmed9120301
Submission received: 25 August 2024 / Revised: 4 October 2024 / Accepted: 22 October 2024 / Published: 7 December 2024
Browse Figure
Versions Notes

Abstract

Providing tuberculosis preventive treatment (TPT) to close contacts of persons with TB is a core strategy recommended by WHO for the prevention and control of TB. Nigeria rolled out the 3-month Isoniazid-Rifampicin (3HR) shorter regimen TPT as a pilot for use among eligible adult and child contacts. This study assesses acceptance and completion rates of 3HR TPT among contacts and determines the perspectives of healthcare workers (HCWs) and contacts on acceptance and completion of 3HR TPT in Nigeria. In this cross-sectional descriptive study using mixed methods, records of TPT-eligible clients were retrospectively reviewed, while 18 purposely selected HCWs and 18 contacts on 3HR were interviewed. Of the 30,012 eligible contacts, 12,040 (40.1%) were initiated on TPT. Among these, 8213 (68%) were enrolled on 3HR, and 6972 (84.7%) of them completed treatment. Perceived facilitators include belief in its effectiveness, training among HCWs, and a good understanding of TPT from HCW counseling sessions. Barriers reported were linked to stockouts, misconceptions about side effects, non-disclosures, and disincentive follow-up strategies. The acceptance and completion rate for 3HR TPT was good. Scaling up 3HR TPT will require redesigning policies towards addressing identified barriers and utilizing interventions linked to capabilities, opportunities, and motivations among contacts of TB patients and HCWs.
Keywords: tuberculosis; TB preventive treatment; contacts; Nigeria tuberculosis; TB preventive treatment; contacts; Nigeria

Share and Cite

MDPI and ACS Style

Ihesie, A.; Chukwuogo, O.; Eneogu, R.; Daniel, O.K.; Agbaje, A.; Odume, B.; Nongo, D.; Ohikhuai, C.; Kadiri-Eneh, N.; Oyelaran, O.; et al. Acceptance and Completion Rates of 3-Month Isoniazid-Rifampicin (3HR) Tuberculosis Preventive Treatment (TPT) Among Contacts of Bacteriologically Confirmed TB Patients—Patients’ and Healthcare Workers’ Perspectives. Trop. Med. Infect. Dis. 2024, 9, 301. https://doi.org/10.3390/tropicalmed9120301

AMA Style

Ihesie A, Chukwuogo O, Eneogu R, Daniel OK, Agbaje A, Odume B, Nongo D, Ohikhuai C, Kadiri-Eneh N, Oyelaran O, et al. Acceptance and Completion Rates of 3-Month Isoniazid-Rifampicin (3HR) Tuberculosis Preventive Treatment (TPT) Among Contacts of Bacteriologically Confirmed TB Patients—Patients’ and Healthcare Workers’ Perspectives. Tropical Medicine and Infectious Disease. 2024; 9(12):301. https://doi.org/10.3390/tropicalmed9120301

Chicago/Turabian Style

Ihesie, Austin, Ogoamaka Chukwuogo, Rupert Eneogu, Olugbenga Kayode Daniel, Aderonke Agbaje, Bethrand Odume, Debby Nongo, Charles Ohikhuai, Nera Kadiri-Eneh, Omosalewa Oyelaran, and et al. 2024. "Acceptance and Completion Rates of 3-Month Isoniazid-Rifampicin (3HR) Tuberculosis Preventive Treatment (TPT) Among Contacts of Bacteriologically Confirmed TB Patients—Patients’ and Healthcare Workers’ Perspectives" Tropical Medicine and Infectious Disease 9, no. 12: 301. https://doi.org/10.3390/tropicalmed9120301

APA Style

Ihesie, A., Chukwuogo, O., Eneogu, R., Daniel, O. K., Agbaje, A., Odume, B., Nongo, D., Ohikhuai, C., Kadiri-Eneh, N., Oyelaran, O., Obianeri, V., Van Gemert, W., Masini, E. O., D’auvergne, C., Ochuko, U., Anyaike, C., & Olarewaju, S. O. (2024). Acceptance and Completion Rates of 3-Month Isoniazid-Rifampicin (3HR) Tuberculosis Preventive Treatment (TPT) Among Contacts of Bacteriologically Confirmed TB Patients—Patients’ and Healthcare Workers’ Perspectives. Tropical Medicine and Infectious Disease, 9(12), 301. https://doi.org/10.3390/tropicalmed9120301

Article Metrics

Back to TopTop