Reducing the Immunogenicity of Pulchellin A-Chain, Ribosome-Inactivating Protein Type 2, by Computational Protein Engineering for Potential New Immunotoxins
, Libing Fu 2, Ricardo Sobhie Diaz 3, Francisco Eduardo Gontijo Guimarães 4, Otávio Cabral-Marques 5,6,7,8,9,10, Gustavo Cabral-Miranda 5,*,†and Mohammad Sadraeian 2,*,†
Round 1
Reviewer 1 Report
Please see the Comments document.
Comments for author File: 
Comments.docx
Author Response
Please see the attachment
Author Response File: Author Response.docx
Reviewer 2 Report
The manuscript described the method to potentially reduce the immunogenecity of a plant-derived toxin by pure computations, which was helpful to guide the following-up experimental validations. There were some typos and grammatical mistakes.
Author Response
We sincerely acknowledge the reviewer for commenting on enhancing clarity and typographical errors.
The clarification for sentences that the reviewer mentioned has been done in the manuscript (refer to sections 3.1 and 3.3). The manuscript was carefully revised and checked to omit typographical errors and grammatical mistakes.
