Theranostic Applications of Nanoparticle-Mediated Photoactivated Therapies

Round 1

Reviewer 1 Report

In the manuscript entitled “Theranostic applications of nanoparticle-mediated photoacti- 2 vated therapies" by Roy I. et al., the authors provide a general overview on the application of theranostic nanoparticles for in vivo image-guided light-activated therapy in cancer.

This is a well-organized and well-illustrated paper. Additionally, the references are appropriate and relevant.

Author Response

Authors: We sincerely thank for learned Referee for her/his highly encouraging comments.

Reviewer 2 Report

In this review, the authors describe theranostic applications of nanoparticle-mediated photoactivated therapies. The manuscript seems scientifically sound.

However, I would suggest some points to be fixed/addressed in the manuscript before publication.

1. The resolution of the picture is too low to see clearly.
2. The content of Table 1 is not classified and does not play a conclusive role.
3. The structure of the manuscript is not clear, for example, there is no good logic for the transition from nanoprobes and nanoparticles to imaging applications in the Introduction. There is no relevant content before targeting defects appear in the Outlook.

Author Response

In this review, the authors describe theranostic applications of nanoparticle-mediated photoactivated therapies. The manuscript seems scientifically sound.

Authors: We sincerely thank for learned Referee for her/his highly encouraging comments.

However, I would suggest some points to be fixed/addressed in the manuscript before publication.

1. The resolution of the picture is too low to see clearly.

Authors: We have enhanced the resolution of all the images.

2. The content of Table 1 is not classified and does not play a conclusive role.

Authors: We have classified the contents of Table 1.

3. The structure of the manuscript is not clear, for example, there is no good logic for the transition from nanoprobes and nanoparticles to imaging applications in the Introduction. There is no relevant content before targeting defects appear in the Outlook.

Authors: Although we sincerely apologize for not being able to restructure this manuscript at this revision stage, as suggested by the learned referee, we have edited this manuscript to the best of our ability for better readability. A new figure (Figure 2 in this revised manuscript) has also been introduced to represent the scope of this review.

Author Response File: Author Response.pdf

Reviewer 3 Report

The authors discussed inorganic nanoparticles as theranostic nanosystems for multimodal imaging-guided therapy. Though authors made efforts to elaborate and highlight the potential of photoactivated therapy by inorganic NPs, major revision is needed to provide a comprehensive and in-depth overview of this topic.

1. A separate section regarding two-dimensional-based theranostic agents should be added, in which black phosphorus, bismuth nanosheets, and MXenes based theranostic systems should be discussed. The authors should cite and discuss some articles along with other recently published literature in that section.
2. Dopamine-based theranostic platform should also be added as a separate section. T
3. A schematic diagram elaborating the scope of this review should be added. The authors should add high quality images. The resolution of the current images are too poor.
4. A separate section elaborating the toxicity of these inorganic NPs should be added to provide an up to date knowledge regarding the progress towards their clinical applicability.

1 watt or 1W. This should be uniform

T1 contrast and r1 relaxivity should be “T₁ and r₁”.

pegylated should be PEGylated.

Use abbreviation for singlet oxygen.

All Latin terms should be italic thorought the manuscript.

Author Response

The authors discussed inorganic nanoparticles as theranostic nanosystems for multimodal imaging-guided therapy. Though authors made efforts to elaborate and highlight the potential of photoactivated therapy by inorganic NPs, major revision is needed to provide a comprehensive and in-depth overview of this topic.

Authors: We sincerely thank for learned Referee for her/his critical and encouraging comments.

1. A separate section regarding two-dimensional-based theranostic agents should be added, in which black phosphorus, bismuth nanosheets, and MXenes based theranostic systems should be discussed. The authors should cite and discuss some articles along with other recently published literature in that section.

Authors: As suggested by the learned Referee, we have added a new section (Section 2.4 in this revised manuscript) covering these highly exciting 2D nanomaterials in theranostic biomedical applications.  

2. Dopamine-based theranostic platform should also be added as a separate section.

Authors: We have added a new section (Section 3.3 in this revised manuscript) covering dopamine-based theranostic nanoplatform.

3. A schematic diagram elaborating the scope of this review should be added. The authors should add high quality images. The resolution of the current images are too poor.

Authors: As suggested by the learned referee, we have included a schematic diagram elaborating the scope of the review (as a new Figure), and also have enhanced the resolution of all the images.

4. A separate section elaborating the toxicity of these inorganic NPs should be added to provide an up to date knowledge regarding the progress towards their clinical applicability.

Authors: As suggested by the learned Referee, we have added a new section (Section 6 in this revised manuscript) covering some toxicological aspects of nanoparticles.

1 watt or 1W. This should be uniform

T1 contrast and r1 relaxivity should be “T₁ and r₁”.

pegylated should be PEGylated.

Use abbreviation for singlet oxygen.

All Latin terms should be italic thorought the manuscript.

Authors: We thank the learned Referee for pointing out these anomalies; we have made all the necessary corrections in this revised manuscript.

Author Response File: Author Response.pdf

Round 2

Reviewer 2 Report

The format of references should be unified. Thanks.

Author Response

As suggested by the learned referee, we have made the reference formats Uniform.