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Communication

Process Improvement for the Continuous Synthesis of N-Benzylhydroxylamine Hydrochloride

by
Xiaoguang Chen
1,2,
Ke Chen
2,
Guoxian Cai
2,
Haoyue Xiang
1,
Kai Chen
1,* and
Hua Yang
1,*
1
College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, China
2
Hunan Warrant Chiral Pharmaceutical Co., Ltd., Changsha 410204, China
*
Authors to whom correspondence should be addressed.
Chemistry 2025, 7(3), 70; https://doi.org/10.3390/chemistry7030070
Submission received: 31 March 2025 / Revised: 22 April 2025 / Accepted: 22 April 2025 / Published: 24 April 2025
(This article belongs to the Topic Green and Sustainable Chemical Products and Processes)
Review Reports Versions Notes

Abstract

N-Benzylhydroxylamine hydrochloride serves as a critical intermediate in organic synthesis, yet traditional synthesis methods often face significant safety risks and high production costs. In this work, we developed a continuous synthesis process for N-benzylhydroxylamine hydrochloride, achieving an overall yield of 75% under mild and safe reaction conditions. Additionally, the implementation of solvent recovery and the recycling of hydroxylamine hydrochloride reduced the production cost to approximately $10 per kilogram. These advancements underscore the economic and practical viability of this method for large-scale industrial applications.
Keywords: N-benzylhydroxylamine hydrochloride; continuous synthesis; flow chemistry N-benzylhydroxylamine hydrochloride; continuous synthesis; flow chemistry

Share and Cite

MDPI and ACS Style

Chen, X.; Chen, K.; Cai, G.; Xiang, H.; Chen, K.; Yang, H. Process Improvement for the Continuous Synthesis of N-Benzylhydroxylamine Hydrochloride. Chemistry 2025, 7, 70. https://doi.org/10.3390/chemistry7030070

AMA Style

Chen X, Chen K, Cai G, Xiang H, Chen K, Yang H. Process Improvement for the Continuous Synthesis of N-Benzylhydroxylamine Hydrochloride. Chemistry. 2025; 7(3):70. https://doi.org/10.3390/chemistry7030070

Chicago/Turabian Style

Chen, Xiaoguang, Ke Chen, Guoxian Cai, Haoyue Xiang, Kai Chen, and Hua Yang. 2025. "Process Improvement for the Continuous Synthesis of N-Benzylhydroxylamine Hydrochloride" Chemistry 7, no. 3: 70. https://doi.org/10.3390/chemistry7030070

APA Style

Chen, X., Chen, K., Cai, G., Xiang, H., Chen, K., & Yang, H. (2025). Process Improvement for the Continuous Synthesis of N-Benzylhydroxylamine Hydrochloride. Chemistry, 7(3), 70. https://doi.org/10.3390/chemistry7030070

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