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10.3390/ebj3020021
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Perspective

Mechanomodulation: Physical Treatment Modalities Employ Mechanotransduction to Improve Scarring

by
Ulrike Van Daele
1,2,*,
Jill Meirte
1,2,
Mieke Anthonissen
1,2,3,
Tine Vanhullebusch
2,
Koen Maertens
1,4,
Lot Demuynck
2 and
Peter Moortgat
1
1
OSCARE, Organisation for Burns, Scar Aftercare and Research, 2170 Antwerp, Belgium
2
Research Group MOVANT (Movement Antwerp), Department of Rehabilitation Sciences and Physiotherapy, University of Antwerp, 2000 Antwerp, Belgium
3
Department of Rehabilitation Sciences, KU Leuven, 3001 Leuven, Belgium
4
Department of Clinical and Lifespan Psychology, Vrije Universiteit Brussel, 1040 Brussels, Belgium
*
Author to whom correspondence should be addressed.
Eur. Burn J. 2022, 3(2), 241-255; https://doi.org/10.3390/ebj3020021
Submission received: 9 February 2022 / Revised: 18 March 2022 / Accepted: 23 March 2022 / Published: 26 March 2022
(This article belongs to the Special Issue Innovation in Burn Scar Prevention and Management)
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Abstract

Every year, surgical interventions, traumatic wounds, and burn injuries lead to over 80 million scars. These scars often lead to compromised skin function and can result in devastating disfigurement, permanent functional loss, psychosocial problems, and growth retardation. Today, a wide variety of nonsurgical scar management options exist, with only few of them being substantiated by evidence. The working mechanisms of physical anti-scarring modalities remained unclear for many years. Recent evidence underpinned the important role of mechanical forces in scar remodeling, especially the balance between matrix stiffness and cytoskeleton pre-stress. This perspective article aims to translate research findings at the cellular and molecular levels into working mechanisms of physical anti-scarring interventions. Mechanomodulation of scars applied with the right amplitude, frequency, and duration induces ECM remodeling and restores the ‘tensile’ homeostasis. Depending on the scar characteristics, specific (combinations of) non-invasive physical scar treatments are possible. Future studies should be aimed at investigating the dose-dependent effects of physical scar management to define proper guidelines for these interventions.
Keywords: scars; remodeling; mechanotransduction; mechanomodulation; physical scar management; dose dependency scars; remodeling; mechanotransduction; mechanomodulation; physical scar management; dose dependency

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MDPI and ACS Style

Van Daele, U.; Meirte, J.; Anthonissen, M.; Vanhullebusch, T.; Maertens, K.; Demuynck, L.; Moortgat, P. Mechanomodulation: Physical Treatment Modalities Employ Mechanotransduction to Improve Scarring. Eur. Burn J. 2022, 3, 241-255. https://doi.org/10.3390/ebj3020021

AMA Style

Van Daele U, Meirte J, Anthonissen M, Vanhullebusch T, Maertens K, Demuynck L, Moortgat P. Mechanomodulation: Physical Treatment Modalities Employ Mechanotransduction to Improve Scarring. European Burn Journal. 2022; 3(2):241-255. https://doi.org/10.3390/ebj3020021

Chicago/Turabian Style

Van Daele, Ulrike, Jill Meirte, Mieke Anthonissen, Tine Vanhullebusch, Koen Maertens, Lot Demuynck, and Peter Moortgat. 2022. "Mechanomodulation: Physical Treatment Modalities Employ Mechanotransduction to Improve Scarring" European Burn Journal 3, no. 2: 241-255. https://doi.org/10.3390/ebj3020021

APA Style

Van Daele, U., Meirte, J., Anthonissen, M., Vanhullebusch, T., Maertens, K., Demuynck, L., & Moortgat, P. (2022). Mechanomodulation: Physical Treatment Modalities Employ Mechanotransduction to Improve Scarring. European Burn Journal, 3(2), 241-255. https://doi.org/10.3390/ebj3020021

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