Donation after Circulatory Death Liver Transplantation in Paediatric Recipients

Round 1

Reviewer 1 Report

This is very well written and comprehensive review. It is an update of a previous published review in Biomed Res Int 2018. 

Some parts are  too detailed.  I would suggest to shorten the second paragraph (remove exact WIT times per country?).

For clarity, I suggest to start paragraph 3 and 4 with the total number of cases (in US §3 and in Eur §4) and total number of studies.

Author Response

The authors would like to thank the reviewer for his positive comments.

Some parts are too detailed. I would suggest to shorten the second paragraph (remove exact WIT times per country?).

Thanks for the comment. The WIT for each country has been deleted accordingly.

For clarity, I suggest to start paragraph 3 and 4 with the total number of cases (in US §3 and in Eur §4) and total number of studies.

Thank you for this thoughtful comment. We have added the total number of papers and patients at the start of each paragraph. 

Reviewer 2 Report

This is a review on the DCD graft for pediatric recipients.

I have some comments.

1. (Title) What is the significance of the subtitle “ where do we stand?” I think it should be omitted.
2. (L89) What is the rate that the pediatric DCD grafts were retrieved? Is the denominator the number of all of the pediatric donors after circulatory death and the numerator the pediatric donors after circulatory death who was actually procured liver?
3. (L116) BMI may be more appropriate as the abbreviation of body mass index.
4. (The last sentence of the text) SIRS and ALPSS needs explanation. The use of abbreviation is not appropriate because they appear once in the text.

Author Response

Many thanks to the reviewer for the good comments.

(Title) What is the significance of the subtitle “ where do we stand?” I think it should be omitted.

We do agree with this point and the title has been changed accordingly. Thanks.

What is the rate that the pediatric DCD grafts were retrieved? Is the denominator the number of all of the pediatric donors after circulatory death and the numerator the pediatric donors after circulatory death who was actually procured liver?

Thanks for these comments. A more detailed description of the manuscript by Little CJ et al has been added. The total number of DCD livers divided per age is now available and this has improved the overall understanding of utilization of paediatric DCD.

BMI may be more appropriate as the abbreviation of body mass index.

This typo has been corrected, thanks for the good spot.

(The last sentence of the text) SIRS and ALPSS needs explanation. The use of abbreviation is not appropriate because they appear once in the text.

This has been amended accordingly.