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Article

High-Avidity Anti-Filovirus IgG Elicited Using Protein Subunit Vaccines Does Not Correlate with Protection

by
Caitlin A. Williams
1,
Teri Ann S. Wong
1,
Michael M. Lieberman
1,
Jake Yalley-Ogunro
2,
Mehtap Cabus
2,
Sara Nezami
2,
Fabian Paz
2,
Hanne Andersen
2,
Thomas W. Geisbert
3 and
Axel T. Lehrer
1,*
1
Department of Tropical Medicine, Medical Microbiology and Pharmacology, John A Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI 96813, USA
2
BIOQUAL, Inc., Rockville, MD 20850, USA
3
Galveston National Laboratory, Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA
*
Author to whom correspondence should be addressed.
Immuno 2023, 3(4), 358-374; https://doi.org/10.3390/immuno3040022
Submission received: 4 August 2023 / Revised: 17 September 2023 / Accepted: 7 October 2023 / Published: 24 October 2023
(This article belongs to the Section Infectious Immunology and Vaccines)
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Abstract

Zaire ebolavirus (EBOV) poses a significant threat to public health due to its high case fatality rate and epidemic potential. This is further complicated by the lack of precise immune correlates of protection and difficulties in conducting in vivo animal studies due to species specificity of Ebola virus disease (EVD) and classification as a biosafety level 4 pathogen. Related ebolaviruses have also contributed to the public health threat; Uganda recently experienced an outbreak of Sudan ebolavirus, which also had a high case fatality rate. Vaccination targeting EBOV has demonstrated significant efficacy; however, the protective cellular and humoral responses at play are still poorly understood. Vaccination for vulnerable populations such as pregnant women, young children, and immunocompromised individuals is still limited. Understanding vaccine correlates of protection (vCOP) is key to developing alternative vaccination strategies for these groups. Components of immunity such as neutralizing antibody and cell-mediated immunity are likely responsible for protective responses; however, existing research fails to fully define their roles in protection. Here we investigated vaccine-elicited antibody avidity as a potential correlate of protection and to further characterize the contribution of antibody avidity in protective and nonprotective vaccine responses.
Keywords: vaccines; filovirus; avidity; nonhuman primates vaccines; filovirus; avidity; nonhuman primates

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MDPI and ACS Style

Williams, C.A.; Wong, T.A.S.; Lieberman, M.M.; Yalley-Ogunro, J.; Cabus, M.; Nezami, S.; Paz, F.; Andersen, H.; Geisbert, T.W.; Lehrer, A.T. High-Avidity Anti-Filovirus IgG Elicited Using Protein Subunit Vaccines Does Not Correlate with Protection. Immuno 2023, 3, 358-374. https://doi.org/10.3390/immuno3040022

AMA Style

Williams CA, Wong TAS, Lieberman MM, Yalley-Ogunro J, Cabus M, Nezami S, Paz F, Andersen H, Geisbert TW, Lehrer AT. High-Avidity Anti-Filovirus IgG Elicited Using Protein Subunit Vaccines Does Not Correlate with Protection. Immuno. 2023; 3(4):358-374. https://doi.org/10.3390/immuno3040022

Chicago/Turabian Style

Williams, Caitlin A., Teri Ann S. Wong, Michael M. Lieberman, Jake Yalley-Ogunro, Mehtap Cabus, Sara Nezami, Fabian Paz, Hanne Andersen, Thomas W. Geisbert, and Axel T. Lehrer. 2023. "High-Avidity Anti-Filovirus IgG Elicited Using Protein Subunit Vaccines Does Not Correlate with Protection" Immuno 3, no. 4: 358-374. https://doi.org/10.3390/immuno3040022

APA Style

Williams, C. A., Wong, T. A. S., Lieberman, M. M., Yalley-Ogunro, J., Cabus, M., Nezami, S., Paz, F., Andersen, H., Geisbert, T. W., & Lehrer, A. T. (2023). High-Avidity Anti-Filovirus IgG Elicited Using Protein Subunit Vaccines Does Not Correlate with Protection. Immuno, 3(4), 358-374. https://doi.org/10.3390/immuno3040022

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