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Applied Biosciences
Volume 3
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10.3390/applbiosci3010008
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Article

Fructooligosaccharides Supplementation: A Good Choice for the Prevention and Treatment of Non-Alcoholic Fatty Liver Disease?

by
Priscila Nogueira Bezan
1,
Héric Holland
1,
Bárbara Ferreira Vercesi
1,*,
Paula Payão Ovídio
1,
Livia Maria Cordeiro Simões
2 and
Alceu Afonso Jordão
1
1
Department of Health Sciences, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto 14049-900, Brazil
2
Department of Internal Medicine, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto 14049-900, Brazil
*
Author to whom correspondence should be addressed.
Appl. Biosci. 2024, 3(1), 123-136; https://doi.org/10.3390/applbiosci3010008
Submission received: 26 October 2023 / Revised: 14 January 2024 / Accepted: 22 February 2024 / Published: 1 March 2024
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Abstract

Background and objectives: Carbohydrates such as fructooligosaccharides (FOSs) are associated with improved gastrointestinal health and the prevention of excess body fat. We evaluated the long-term effects of high amounts of FOS on metabolic parameters, non-alcoholic fatty liver disease (NAFLD) and short-chain fatty acids (SCFAs). Methods: Sixty C57BL/6 mice received the following diets for four months: control (C), normolipid rich in fiber (F), normolipid supplemented with FOS (FOS), high fat (HL), high fat with high fiber (HLF) and high fat with FOS (HLFOS). We analyzed the animal weight; body composition; food intake; fasting blood glucose; serum and liver lipid profiles; liver and intestinal histologies; malondialdehyde (MDA), hepatic retinol and α-tocopherol; and SCFAs in the feces. Results: Supplementation with FOS in a high-fat diet promoted less body weight gain and reduced liver and retroperitoneal adipose tissue weights compared to HL and HF. FOS prevented NASH and decreased alanine aminotransferase and serum cholesterol levels in experimental animal models of obesity and metabolic syndrome (MS). There were statistical differences found in the dosages of the three main SCFAs in feces (acetic, isobutyric and isovaleric acids). Conclusions: Long-term supplementation with high doses of FOS was effective in reducing weight, adiposity, NAFLD and serum cholesterol in C57BL mice with obesity and MS induced by a high-fat diet.
Keywords: fructooligosaccharides (FOS); hyperlipidic diet; non-alcoholic fatty liver disease (NAFLD); prebiotics fructooligosaccharides (FOS); hyperlipidic diet; non-alcoholic fatty liver disease (NAFLD); prebiotics

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MDPI and ACS Style

Bezan, P.N.; Holland, H.; Vercesi, B.F.; Ovídio, P.P.; Simões, L.M.C.; Jordão, A.A. Fructooligosaccharides Supplementation: A Good Choice for the Prevention and Treatment of Non-Alcoholic Fatty Liver Disease? Appl. Biosci. 2024, 3, 123-136. https://doi.org/10.3390/applbiosci3010008

AMA Style

Bezan PN, Holland H, Vercesi BF, Ovídio PP, Simões LMC, Jordão AA. Fructooligosaccharides Supplementation: A Good Choice for the Prevention and Treatment of Non-Alcoholic Fatty Liver Disease? Applied Biosciences. 2024; 3(1):123-136. https://doi.org/10.3390/applbiosci3010008

Chicago/Turabian Style

Bezan, Priscila Nogueira, Héric Holland, Bárbara Ferreira Vercesi, Paula Payão Ovídio, Livia Maria Cordeiro Simões, and Alceu Afonso Jordão. 2024. "Fructooligosaccharides Supplementation: A Good Choice for the Prevention and Treatment of Non-Alcoholic Fatty Liver Disease?" Applied Biosciences 3, no. 1: 123-136. https://doi.org/10.3390/applbiosci3010008

APA Style

Bezan, P. N., Holland, H., Vercesi, B. F., Ovídio, P. P., Simões, L. M. C., & Jordão, A. A. (2024). Fructooligosaccharides Supplementation: A Good Choice for the Prevention and Treatment of Non-Alcoholic Fatty Liver Disease? Applied Biosciences, 3(1), 123-136. https://doi.org/10.3390/applbiosci3010008

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