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Review

The Effects of Vitamin D on Preventing Hyperglycemia and a Novel Approach to Its Treatment

by
Suchitra Monapati
1,*,
Pavani Kaki
2,
Mary Stella Gurajapu
2,
Prathibha Guttal Subhas
3 and
Harinadha Baba Kudipudi
4
1
Department of Pharmaceutical Chemistry, Narayana Pharmacy College, Nellore 524004, India
2
Department of Pharm.D Narayana Pharmacy College, Nellore 524004, India
3
Department of Pharmacognosy, Bapuji Pharmacy College, Davanagere 577004, India
4
Department of Pharmaceutical Analysis, Narayana Pharmacy College, Nellore 524004, India
*
Author to whom correspondence should be addressed.
Drugs Drug Candidates 2023, 2(4), 923-936; https://doi.org/10.3390/ddc2040046
Submission received: 30 August 2023 / Revised: 10 November 2023 / Accepted: 21 November 2023 / Published: 28 November 2023
(This article belongs to the Section Clinical Research)
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Abstract

The dietary reference levels for vitamin D were established with an emphasis on its role in bone health; however, with the identification of vitamin D receptors in all body tissues novel associations with other metabolic disorders, such as diabetes, are being researched. Aside from its standard function as the main regulator of calcium absorption, vitamin D also controls the calcium pool, mediates the activity of beta cell calcium-dependent endopeptidases, encourages the conversion of proinsulin to insulin, increases insulin output, and raises insulin activity in peripheral insulin target tissues. Both immune cells and pancreatic beta cells include vitamin D receptors. A deficiency of vitamin D causes glucose intolerance and affects insulin secretion. Different pathogenic characteristics of the disease are linked to a number of vitamin D-related genes. It has been proven that vitamin D supplementation lowers the risk of type 1 and type 2 diabetes and its associated problems. In this article, we discussed a few prospective clinical trials on vitamin D that are necessary to clearly demonstrate the role of vitamin D in the prevention and management of diabetes.
Keywords: vitamin D; diabetes mellitus; insulin resistance; beta cell protection; cholecalciferol vitamin D; diabetes mellitus; insulin resistance; beta cell protection; cholecalciferol

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MDPI and ACS Style

Monapati, S.; Kaki, P.; Gurajapu, M.S.; Subhas, P.G.; Kudipudi, H.B. The Effects of Vitamin D on Preventing Hyperglycemia and a Novel Approach to Its Treatment. Drugs Drug Candidates 2023, 2, 923-936. https://doi.org/10.3390/ddc2040046

AMA Style

Monapati S, Kaki P, Gurajapu MS, Subhas PG, Kudipudi HB. The Effects of Vitamin D on Preventing Hyperglycemia and a Novel Approach to Its Treatment. Drugs and Drug Candidates. 2023; 2(4):923-936. https://doi.org/10.3390/ddc2040046

Chicago/Turabian Style

Monapati, Suchitra, Pavani Kaki, Mary Stella Gurajapu, Prathibha Guttal Subhas, and Harinadha Baba Kudipudi. 2023. "The Effects of Vitamin D on Preventing Hyperglycemia and a Novel Approach to Its Treatment" Drugs and Drug Candidates 2, no. 4: 923-936. https://doi.org/10.3390/ddc2040046

APA Style

Monapati, S., Kaki, P., Gurajapu, M. S., Subhas, P. G., & Kudipudi, H. B. (2023). The Effects of Vitamin D on Preventing Hyperglycemia and a Novel Approach to Its Treatment. Drugs and Drug Candidates, 2(4), 923-936. https://doi.org/10.3390/ddc2040046

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