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Review

Urate Biology and Biochemistry: A Year in Review 2022

by
Rachel D. King
1 and
Eric E. Kelley
2,*
1
Department of Biochemistry, School of Medicine, West Virginia University, Morgantown, WV 15902, USA
2
Department of Physiology and Pharmacology, School of Medicine, West Virginia University, Morgantown, WV 15902, USA
*
Author to whom correspondence should be addressed.
Gout Urate Cryst. Depos. Dis. 2023, 1(3), 115-121; https://doi.org/10.3390/gucdd1030011
Submission received: 6 March 2023 / Revised: 16 June 2023 / Accepted: 20 June 2023 / Published: 23 June 2023
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Abstract

The past year generated significant change and advancement of the urate field with novel insights regarding the role of uric acid (UA) in multiple pathophysiologic processes from gout to COVID-19. While these contributions continue to move the field forward, the basic biochemistry and biology of UA is often overlooked, being lost in the shadow of clinical associations and omics. However, the seminal impact of UA begins with biochemistry and the associated interplay with cell biology. In these basic reactions and resultant impacts on physiology, UA mediates its influence on clinical outcomes. As such, this review focuses on published advances in UA biochemistry and biology in 2022 and associates these advances with downstream consequences.
Keywords: uric acid; uricase; xanthine; hypoxanthine; xanthine oxidoreductase uric acid; uricase; xanthine; hypoxanthine; xanthine oxidoreductase

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MDPI and ACS Style

King, R.D.; Kelley, E.E. Urate Biology and Biochemistry: A Year in Review 2022. Gout Urate Cryst. Depos. Dis. 2023, 1, 115-121. https://doi.org/10.3390/gucdd1030011

AMA Style

King RD, Kelley EE. Urate Biology and Biochemistry: A Year in Review 2022. Gout, Urate, and Crystal Deposition Disease. 2023; 1(3):115-121. https://doi.org/10.3390/gucdd1030011

Chicago/Turabian Style

King, Rachel D., and Eric E. Kelley. 2023. "Urate Biology and Biochemistry: A Year in Review 2022" Gout, Urate, and Crystal Deposition Disease 1, no. 3: 115-121. https://doi.org/10.3390/gucdd1030011

APA Style

King, R. D., & Kelley, E. E. (2023). Urate Biology and Biochemistry: A Year in Review 2022. Gout, Urate, and Crystal Deposition Disease, 1(3), 115-121. https://doi.org/10.3390/gucdd1030011

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