Metabolic Stress Alters Antioxidant Systems, Suppresses the Adiponectin Receptor 1 and Induces Alzheimer’s Like Pathology in Mice Brain
Abstract
:1. Introduction
2. Materials and Methods
2.1. Chemicals
2.2. Animals and Diets
2.3. Behavioral Analysis: Morris Water Maze (MWM) and Y-Maze Test
2.4. Insulin Sensitivity and Glucose Tolerance Tests
2.5. Extraction of Murine Brain Proteins
2.6. Western Blotting Analysis
2.7. Cell Culturing
2.8. Cell Transfection
2.9. Detection of Oxidative Stress (In Vivo and In Vitro)
2.10. Assessment of Lipid Peroxidation (In Vivo and In Vitro)
2.11. Glutathione Assays
2.12. Immunofluorescence
2.13. Antibodies
2.14. Thioflavin S Staining of Aβ Plaques
2.15. Data and Statistical Analysis
3. Results
3.1. HFD-Induced Obesity Deregulates Metabolic Parameters in Mice
3.2. HFD Induces Oxidative-Stress-Mediated Brain Insulin Resistance by Impairing AdipoR1/P-AMPK Signaling Both In Vivo and In Vitro
3.3. Chronic HFD Consumption Activates Astrocytes and Microglia and Exacerbates Neuroinflammation in Mouse Brains
3.4. HFD Induces AD-Like Pathology in Mouse Brains
3.5. HFD Induces Synaptic Dysfunction and Memory Impairment in Mouse Brains
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Conflicts of Interest
References
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Hahm, J.R.; Jo, M.H.; Ullah, R.; Kim, M.W.; Kim, M.O. Metabolic Stress Alters Antioxidant Systems, Suppresses the Adiponectin Receptor 1 and Induces Alzheimer’s Like Pathology in Mice Brain. Cells 2020, 9, 249. https://doi.org/10.3390/cells9010249
Hahm JR, Jo MH, Ullah R, Kim MW, Kim MO. Metabolic Stress Alters Antioxidant Systems, Suppresses the Adiponectin Receptor 1 and Induces Alzheimer’s Like Pathology in Mice Brain. Cells. 2020; 9(1):249. https://doi.org/10.3390/cells9010249
Chicago/Turabian StyleHahm, Jong Ryeal, Myeung Hoon Jo, Rahat Ullah, Min Woo Kim, and Myeong Ok Kim. 2020. "Metabolic Stress Alters Antioxidant Systems, Suppresses the Adiponectin Receptor 1 and Induces Alzheimer’s Like Pathology in Mice Brain" Cells 9, no. 1: 249. https://doi.org/10.3390/cells9010249