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Clinics and Practice
Volume 1
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10.4081/cp.2011.e95
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Clinics and Practice is published by MDPI from Volume 11 Issue 1 (2021). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with PAGEPress.
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Case Report

Long-Term Reversibility of Renal Dysfunction Associated to Light Chain Deposition Disease with Bortezomib and Dexamethasone and High Dose Therapy and Autologous Stem Cell Transplantation

by
Tomás J. González-López
1,
Lourdes Vázquez
1,
Teresa Flores
2,
Jesus Fernando San Miguel
1 and
Ramon García-Sanz
1,*
1
Hematology Department, Salamanca, Spain
2
Pathology Service, University Hospital of Salamanca, Salamanca, Spain
*
Author to whom correspondence should be addressed.
Clin. Pract. 2011, 1(4), e95; https://doi.org/10.4081/cp.2011.e95
Submission received: 19 September 2011 / Revised: 19 September 2011 / Accepted: 11 October 2011 / Published: 23 November 2011

Abstract

A 63-year-old woman presented with progressive renal insufficiency, until a glomerular filtration rate (GFR) of 12 mL/min. A renal biopsy demonstrated glomerular deposition of immunoglobulin k light chain. The presence of a small population of monoclonal plasmacytes producing an only light k monoclonal component was demonstrated and Bortezomib and Dexamethasone (BD) was provided as initial therapy. After seven courses of therapy, renal function improved without dialysis requirements up to a GFR 31 mL/min. Under hematological complete response (HCR) the patient underwent high dose of melphalan (HDM) and autologous peripheral blood stem cell transplant. Fifty-four months later the patient remains in HCR and the GFR has progressively improved up to 48 mL/min. This report describes a notably renal function improvement in a patient with Light Chain Deposition Disease after therapy with BD followed by HDM, which can support this treatment as a future option for these patients.
Keywords: light chain deposition disease; free light chain; monoclonal gammopathy; bortezomib; transplant light chain deposition disease; free light chain; monoclonal gammopathy; bortezomib; transplant

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MDPI and ACS Style

González-López, T.J.; Vázquez, L.; Flores, T.; San Miguel, J.F.; García-Sanz, R. Long-Term Reversibility of Renal Dysfunction Associated to Light Chain Deposition Disease with Bortezomib and Dexamethasone and High Dose Therapy and Autologous Stem Cell Transplantation. Clin. Pract. 2011, 1, e95. https://doi.org/10.4081/cp.2011.e95

AMA Style

González-López TJ, Vázquez L, Flores T, San Miguel JF, García-Sanz R. Long-Term Reversibility of Renal Dysfunction Associated to Light Chain Deposition Disease with Bortezomib and Dexamethasone and High Dose Therapy and Autologous Stem Cell Transplantation. Clinics and Practice. 2011; 1(4):e95. https://doi.org/10.4081/cp.2011.e95

Chicago/Turabian Style

González-López, Tomás J., Lourdes Vázquez, Teresa Flores, Jesus Fernando San Miguel, and Ramon García-Sanz. 2011. "Long-Term Reversibility of Renal Dysfunction Associated to Light Chain Deposition Disease with Bortezomib and Dexamethasone and High Dose Therapy and Autologous Stem Cell Transplantation" Clinics and Practice 1, no. 4: e95. https://doi.org/10.4081/cp.2011.e95

APA Style

González-López, T. J., Vázquez, L., Flores, T., San Miguel, J. F., & García-Sanz, R. (2011). Long-Term Reversibility of Renal Dysfunction Associated to Light Chain Deposition Disease with Bortezomib and Dexamethasone and High Dose Therapy and Autologous Stem Cell Transplantation. Clinics and Practice, 1(4), e95. https://doi.org/10.4081/cp.2011.e95

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