The Journal of Clinical Medicine (JCM, ISSN: 2077-0383) is an international, peer-reviewed, open access journal published semimonthly online by MDPI, where you have free and unlimited access to the full text of all of the published articles. The International Bone Research Association (IBRA), Italian Resuscitation Council (IRC), Spanish Society of Hematology and Hemotherapy (SEHH), Japan Association for Clinical Engineers (JACE), European Independent Foundation in Angiology/Vascular Medicine (VAS) and others are all affiliated with JCM, and their members receive a discount on article processing charges.

JCM covers all topics related to clinical and pre-clinical practices and is dedicated to publishing high-quality original research, reviews or perspectives on clinical practice. We invite you to read our most cited papers published in 2021:

1. "Volatile Organic Compounds in Exhaled Breath as Fingerprints of Lung Cancer, Asthma and COPD"
by Ileana Andreea Ratiu, Tomasz Ligor, Victor Bocos-Bintintan, Chris A Mayhew and Bogusław Buszewski
J. Clin. Med. 2021, 10(1), 32; https://doi.org/10.3390/jcm10010032
Available online: https://www.mdpi.com/2077-0383/10/1/32

2. "Denosumab Discontinuation and the Rebound Phenomenon: A Narrative Review"
by Athanasios D. Anastasilakis, Polyzois Makras, Maria P. Yavropoulou, Gaia Tabacco, Anda Mihaela Naciu and Andrea Palermo
J. Clin. Med. 2021, 10(1), 152; https://doi.org/10.3390/jcm10010152
Available online: https://www.mdpi.com/2077-0383/10/1/152

3. "Proposal of the Definition for COVID-19-Associated Coagulopathy"
by Toshiaki Iba, Theodore E. Warkentin, Jecko Thachil, Marcel Levi and Jerrold H. Levy
J. Clin. Med. 2021, 10(2), 191; https://doi.org/10.3390/jcm10020191
Available online: https://www.mdpi.com/2077-0383/10/2/191

4. "Head-to-Head Comparison of Rapid and Automated Antigen Detection Tests for the Diagnosis of SARS-CoV-2 Infection"
by Julien Favresse, Constant Gillot, Maxime Oliveira, Julie Cadrobbi, Marc Elsen, Christine Eucher, Kim Laffineur, Catherine Rosseels, Sandrine Van Eeckhoudt, Jean-Baptiste Nicolas et al.
J. Clin. Med. 2021, 10(2), 265; https://doi.org/10.3390/jcm10020265
Available online: https://www.mdpi.com/2077-0383/10/2/265

5. "Oxidative Stress and Inflammation Biomarker Expression in Obstructive Sleep Apnea Patients"
by Antonino Maniaci, Giannicola Iannella, Salvatore Cocuzza, Claudio Vicini, Giuseppe Magliulo, Salvatore Ferlito, Giovanni Cammaroto, Giuseppe Meccariello, Andrea De Vito, Alice Nicolai et al.
J. Clin. Med. 2021, 10(2), 277; https://doi.org/10.3390/jcm10020277
Available online: https://www.mdpi.com/2077-0383/10/2/277

6. "The Impact of COVID-19 Pandemic and Lockdown Measures on Quality of Life among Italian General Population"
by Maria Stella Epifanio, Federica Andrei, Giacomo Mancini, Francesca Agostini, Marco Andrea Piombo, Vittoria Spicuzza, Martina Riolo, Gioacchino Lavanco, Elena Trombini and Sabina La Grutta
J. Clin. Med. 2021, 10(2), 289; https://doi.org/10.3390/jcm10020289
Available online: https://www.mdpi.com/2077-0383/10/2/289

7. "Skin Barrier Function in Psoriasis and Atopic Dermatitis: Transepidermal Water Loss and Temperature as Useful Tools to Assess Disease Severity"
by Trinidad Montero-Vilchez, María-Victoria Segura-Fernández-Nogueras, Isabel Pérez-Rodríguez, Miguel Soler-Gongora, Antonio Martinez-Lopez, Ana Fernández-González, Alejandro Molina-Leyva and Salvador Arias-Santiago
J. Clin. Med. 2021, 10(2), 359; https://doi.org/10.3390/jcm10020359
Available online: https://www.mdpi.com/2077-0383/10/2/359

8. "Incidence and Prognosis of Ventilator-Associated Pneumonia in Critically Ill Patients with COVID-19: A Multicenter Study"
by Daniele Roberto Giacobbe, Denise Battaglini, Elisa Martina Enrile, Chiara Dentone, Antonio Vena, Chiara Robba, Lorenzo Ball, Michele Bartoletti, Irene Coloretti, Stefano Di Bella et al.
J. Clin. Med. 2021, 10(4), 555; https://doi.org/10.3390/jcm10040555
Available online: https://www.mdpi.com/2077-0383/10/4/555

9. "Therapeutic Features and Updated Clinical Trials of Mesenchymal Stem Cell (MSC)-Derived Exosomes"
by Byung-Chul Lee, Insung Kang and Kyung-Rok Yu
J. Clin. Med. 2021, 10(4), 711; https://doi.org/10.3390/jcm10040711
Available online: https://www.mdpi.com/2077-0383/10/4/711

10. "Prevalence of COVID-19 Vaccine Side Effects among Healthcare Workers in the Czech Republic"
by Abanoub Riad, Andrea Pokorná, Sameh Attia, Jitka Klugarová, Michal Koščík and Miloslav Klugar
J. Clin. Med. 2021, 10(7), 1428; https://doi.org/10.3390/jcm10071428
Available online: https://www.mdpi.com/2077-0383/10/7/1428

11. "Thrombocytopenia and Intracranial Venous Sinus Thrombosis after “COVID-19 Vaccine AstraZeneca” Exposure"
by Marc E. Wolf, Beate Luz, Ludwig Niehaus, Pervinder Bhogal, Hansjörg Bäzner and Hans Henkes
J. Clin. Med. 2021, 10(8), 1599; https://doi.org/10.3390/jcm10081599
Available online: https://www.mdpi.com/2077-0383/10/8/1599

12. "Prevalence and Risk Factors of CoronaVac Side Effects: An Independent Cross-Sectional Study among Healthcare Workers in Turkey"
by Abanoub Riad, Derya Sağıroğlu, Batuhan Üstün, Andrea Pokorná, Jitka Klugarová, Sameh Attia and Miloslav Klugar
J. Clin. Med. 2021, 10(12), 2629; https://doi.org/10.3390/jcm10122629
Available online: https://www.mdpi.com/2077-0383/10/12/2629

13. "Demographic and Clinical Overview of Hospitalized COVID-19 Patients during the First 17 Months of the Pandemic in Poland"
by Robert Flisiak, Piotr Rzymski, Dorota Zarębska-Michaluk, Magdalena Rogalska, Marta Rorat, Piotr Czupryna, Beata Lorenc, Przemysław Ciechanowski, Dorota Kozielewicz, Anna Piekarska et al.
J. Clin. Med. 2022, 11(1), 117; https://doi.org/10.3390/jcm11010117
Available online: https://www.mdpi.com/2077-0383/11/1/117

14. "Relative Reproduction Number of SARS-CoV-2 Omicron (B.1.1.529) Compared with Delta Variant in South Africa"
by Hiroshi Nishiura, Kimihito Ito, Asami Anzai, Tetsuro Kobayashi, Chayada Piantham and Alfonso J. Rodríguez-Morales
J. Clin. Med. 2022, 11(1), 30; https://doi.org/10.3390/jcm11010030
Available online: https://www.mdpi.com/2077-0383/11/1/30

15. "The Role of Antioxidants on Wound Healing: A Review of the Current Evidence"
by Inés María Comino-Sanz, María Dolores López-Franco, Begoña Castro and Pedro Luis Pancorbo-Hidalgo
J. Clin. Med. 2021, 10(16), 3558; https://doi.org/10.3390/jcm10163558
Available online: https://www.mdpi.com/2077-0383/10/16/3558

16. "Nociplastic Pain Criteria or Recognition of Central Sensitization? Pain Phenotyping in the Past, Present and Future"
by Jo Nijs, Astrid Lahousse, Eleni Kapreli, Paraskevi Bilika, İsmail Saraçoğlu, Anneleen Malfliet, Iris Coppieters, Liesbet De Baets, Laurence Leysen, Eva Roose et al.
J. Clin. Med. 2021, 10(15), 3203; https://doi.org/10.3390/jcm10153203
Available online: https://www.mdpi.com/2077-0383/10/15/3203

17. "The Impact of Dental Implant Surface Modifications on Osseointegration and Biofilm Formation"
by Stefanie Kligman, Zhi Ren, Chun-Hsi Chung, Michael Angelo Perillo, Yu-Cheng Chang, Hyun Koo, Zhong Zheng and Chenshuang Li
J. Clin. Med. 2021, 10(8), 1641; https://doi.org/10.3390/jcm10081641
Available online: https://www.mdpi.com/2077-0383/10/8/1641

18. "The Exoscope in Neurosurgery: An Overview of the Current Literature of Intraoperative Use in Brain and Spine Surgery"
by Nicola Montemurro, Alba Scerrati, Luca Ricciardi and Gianluca Trevisi
J. Clin. Med. 2022, 11(1), 223; https://doi.org/10.3390/jcm11010223
Available online: https://www.mdpi.com/2077-0383/11/1/223

19. "Therapeutic Advances in Diabetic Nephropathy"
by Hanny Sawaf, George Thomas, Jonathan J. Taliercio, Georges Nakhoul, Tushar J. Vachharajani and Ali Mehdi
J. Clin. Med. 2022, 11(2), 378; https://doi.org/10.3390/jcm11020378
Available online: https://www.mdpi.com/2077-0383/11/2/378

20. "The Association between Early-Life Gut Microbiota and Long-Term Health and Diseases"
by Anujit Sarkar, Ji Youn Yoo, Samia Valeria Ozorio Dutra, Katherine H. Morgan and Maureen Groer
J. Clin. Med. 2021, 10(3), 459; https://doi.org/10.3390/jcm10030459
Available online: https://www.mdpi.com/2077-0383/10/3/459

21. "Long-Term Outcomes of Patients with Coronavirus Disease 2019 at One Year after Hospital Discharge"
by Modesto M. Maestre-Muñiz, Ángel Arias, Emilia Mata-Vázquez, María Martín-Toledano, Germán López-Larramona, Ana María Ruiz-Chicote, Bárbara Nieto-Sandoval and Alfredo J. Lucendo
J. Clin. Med. 2021, 10(13), 2945; https://doi.org/10.3390/jcm10132945
Available online: https://www.mdpi.com/2077-0383/10/13/2945

22. "The Comparative Clinical Performance of Four SARS-CoV-2 Rapid Antigen Tests and Their Correlation to Infectivity In Vitro"
by Niko Kohmer, Tuna Toptan, Christiane Pallas, Onur Karaca, Annika Pfeiffer, Sandra Westhaus, Marek Widera, Annemarie Berger, Sebastian Hoehl, Martin Kammel et al.
J. Clin. Med. 2021, 10(2), 328; https://doi.org/10.3390/jcm10020328
Available online: https://www.mdpi.com/2077-0383/10/2/328

23. "Multi-Organ Involvement in COVID-19: Beyond Pulmonary Manifestations"
by Vikram Thakur, Radha Kanta Ratho, Pradeep Kumar, Shashi Kant Bhatia, Ishani Bora, Gursimran Kaur Mohi, Shailendra K Saxena, Manju Devi, Dhananjay Yadav and Sanjeet Mehariya
J. Clin. Med. 2021, 10(3), 446; https://doi.org/10.3390/jcm10030446
Available online: https://www.mdpi.com/2077-0383/10/3/446