Outcomes of the Pregnancies with Chronic Myeloid Leukemia in the Tyrosine Kinase Inhibitor Era and Literature Review
Abstract
:1. Introduction
2. Case Presentations
3. Discussion
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Study | n | Treatment during Pregnancy | Elective Abortion | Spontaneous Abortion | Fetal Abnormalities | Normal Live Birth | Unknown Outcome |
---|---|---|---|---|---|---|---|
Pye et al. | 180 | 1st trimester Imatinib use: 70% 1st-3rd trimester Imatinib use 26% | 19% | 10% | 7% | 35% | 31% |
Abruzzese et al. | 265 | Exposed to Imatinib during organogenesis (>5-week gestation) | 17% | 9% | 6% | 48% | 21% |
Cortes et al. | 78 | Dasatinib | 23% | 10% | 9% | 19% | 41% |
Wang et al. | 25 | Imatinib: 24 patients Nilotinib: 1 patient | 44% | 175 | 0% | 39% | 0% |
Hall et al. | 6 | 1st trimester TKI use: 4 patients 1st-3rd trimester TKI use: 1 patient | 17% | 17% | 33% | 33% | 0% |
Study | n | Pre-Pregnancy Treatment | Therapy during Pregnancy | Outcomes |
---|---|---|---|---|
Balsat et al. | 12 | 7 Imatinib, 3 Nilotinib, 2 None | 9 PEG-IFN, 2 IFN | 12 live healthy births |
Law et al.. | 6 | 6 Imatinib | 5 IFN, 1 Observation | 1 elective abortion 5 full term deliveries |
Chelyshava et al. | 48 | Unclear | 14 Observation, 5 IFN, 1HU | 14 elective abortions 1 spontaneous abortion 7 live healthy births |
Alizadeh et al. | 28 (16 patients) | 13 Imatinib: 2 Dasatinib 1 Nilotinib | 8 Observation, 8 IFN | 1 spontaneous abortion 2 congenital defects 23 lives healthy births |
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Castillo, D.R.; Park, D.; Mehta, A.; Kaur, S.; Nguyen, A.; Akhtari, M. Outcomes of the Pregnancies with Chronic Myeloid Leukemia in the Tyrosine Kinase Inhibitor Era and Literature Review. Hematol. Rep. 2022, 14, 45-53. https://doi.org/10.3390/hematolrep14010008
Castillo DR, Park D, Mehta A, Kaur S, Nguyen A, Akhtari M. Outcomes of the Pregnancies with Chronic Myeloid Leukemia in the Tyrosine Kinase Inhibitor Era and Literature Review. Hematology Reports. 2022; 14(1):45-53. https://doi.org/10.3390/hematolrep14010008
Chicago/Turabian StyleCastillo, Dan Ran, Daniel Park, Akhil Mehta, Simmer Kaur, Anthony Nguyen, and Mojtaba Akhtari. 2022. "Outcomes of the Pregnancies with Chronic Myeloid Leukemia in the Tyrosine Kinase Inhibitor Era and Literature Review" Hematology Reports 14, no. 1: 45-53. https://doi.org/10.3390/hematolrep14010008