History of “Lacunar Infarction”
Abstract
The concept of lacunar infarction has evolved over the last 200 years, from the first neuropathological observations to the current definition based on neuroimaging. In this chapter, the historical evolution of lacunar infarcts definition is reviewed, from the first original description by Amédée Dechambre to the detailed studies by Maxime Durand-Fardel and Virchow. The evolution of the pathogenetic and the etiological considerations from those of Binswanger, Alzheimer, and Pierre Marie to the memorable work of C. Miller Fisher are also revised. The critics to the lacunar hypothesis and the modern neuroimaging aspects are also considered.
