*2.2. Study Selection*

According to the objective of the study, the TEP defined the characteristics of the sources of evidence, considering for eligibility any researches published in medical literature in the last 10 years (last update on 16 October 2019), including only those in the English language.

#### *2.3. Data Extraction and Quality Assessment*

All types of studies were included in our scoping review, both pre-clinical (in vitro and animal studies) and clinical studies. Methodological quality assessment was made according to the EBM pyramid: meta-analysis, systematic review, randomized controlled trial (RCT), cohort study, case–control study, case series, and case report.

Finally, the TEP summarized the resulting micronutrients with e ffective and safe daily doses that improve bone and tooth health.
