*Search Strategy*

An electronic literature search was conducted using Cochrane Library, Medline (OvidSP), Google Scholar, and PubMed through January 2018. Additional articles were identified from references located in the retrieved articles. Our search strategy included combinations of the following using Boolean markers: *Smallanthus sonchifolius*, yacon, health, prebiotic, phytochemicals, and fructans. The search was restricted to experimental, epidemiological, and clinical studies published in English that address the phytochemical constituents and nutrigenomic properties of yacon. Our work will also add to the current understanding of some of the bioactive compounds and nutrigenomic properties of yacon that were covered adequately in the previous reviews [2].

### **2. Phytochemical Compounds**
