**4. Conclusions**

Yacon has multiple nutrigenomic implications with regard to health outcomes. In addition, yacon is a useful resource for alternative and complementary prebiotics, for example, for intestinal health and for their antimicrobial and antioxidant effects. Although yacon has a long history as a root-based fruit in South America, future studies are needed to better elucidate its mechanisms and nutrigenomic properties regarding health outcomes. This is because there are limited data, especially on the safety evaluation of yacon. In addition, having a better understanding of the effects and mechanisms involved would allow yacon to be developed as a novel functional food as well.

**Acknowledgments:** Zheng Feei Ma would like to thank Siew Poh Tan, Peng Keong Ma, Siew Huah Tan, Feng Yuan Lau, and Zheng Xiong Ma for their active encouragemen<sup>t</sup> and support of this work. The authors received no specific funding for this work.

**Author Contributions:** The project idea was developed by Z.F.M. Y.C. and Z.F.M. wrote the first draft of the manuscript. Y.C., Z.F.M., H.Z., Y.J., Y.Z., and F.H. conducted the literature review and revised the manuscript.

**Conflicts of Interest:** The authors declare no conflict of interest.
