*4.7. Statistical Analysis*

The calculated values for the in vitro and in vivo experiments are expressed as mean ± SD. Student's *t* test was used for statistical analysis.

**Author Contributions:** Conceptualization, H.H.; Data curation, M.T., K.T., M.S., K.Y. and M.M.; Formal analysis, K.T., M.E. and R.I.; Investigation, S.A.; Resources, S.A.; Supervision, K.A.; Writing—original draft, H.H. All authors have read and agreed to the published version of the manuscript.

**Funding:** This research received no external funding.

**Acknowledgments:** The authors thank Y. Matsushima and T. Taira for discussing this study with them.

**Conflicts of Interest:** Authors do not have any conflicts of interest.
