*4.1. Cell Culture*

OMM-1, a uveal melanoma cell line [36] was kindly donated by Dr. Sarah Coupland. The cultivation mediumRPMI 1640 (Merck, Darmstadt, Germany) was added with 10% fetal calf serum (Linaris GmbH, Wertheim-Bettingen, Germany) and 1% penicillin/streptomycin (Merck). The human RPE cell line ARPE-19 [37] was bought from ATCC and cultivated in HyClone DMEM (GE Healthcare, München, Germany), supplemented with 1% penicillin/streptomycin, 2.5% HEPES (Merck), 1% non-essential amino acids (Merck) and 10% fetal calf serum. ARPE-19 cells were treated at confluence and OMM-1 cells were treated at subconfluence.

#### *4.2. Used Fucoidans, Extraction and Purification Process*
