Circulating miR-155

Maternal plasma from preeclamptic women presented significantly statistically higher levels of miR-155 [283]. In blood, microRNAs are quite stable and can travel through circulation, to be uptaken by di fferent cell types, such as endothelial and immune cells, regulating gene expression [284]. Yang, Zhang and Ding (2017) showed how plasma levels of miR-155 positively correlate with proinflammatory cytokine interleukin-17 (IL-17) and with proteinuria and urine podocytes counts in women with preeclampsia. Similarly to miR-210, miR-155 promoter presents a binding site for NFκ-B and can be activated by this inflammation master regulator, which could sugges<sup>t</sup> a similar pattern of regulation for miR-155 and pro-inflammatory factors, other than a direct interaction between these genes [285].
