*8.2. Change in Partner*

Partner change is also considered by many to be a risk factor for preeclampsia, and is attributed to a maternal immune reaction against new paternal antigens expressed in the placenta [78]. Despite original studies indicating the importance of partner change as a risk factor, larger and more recent epidemiological studies in normal and assisted conception pregnancies have demonstrated that partner change is a proxy for lengthening inter-pregnancy intervals and advanced maternal age. Skjaerven and colleagues have demonstrated that a change of partner is not associated with an increased risk of preeclampsia after adjustment for the interval between births and maternal age [79,80].
