*3.2. Non Coding RNAs*

Non-coding RNAs have been found to be differentially expressed in preeclampsia by a number of sources. Some studies have focused on investigating differential expression patterns between PE placental samples of different severities versus control groups looking for miRNAs or lncRNA [223–226], without generally identifying consensual signatures. With the aim of identifying potential biomarkers that could be used diagnostically to predict preeclampsia onset, many groups have set out instead to identify molecules differentially expressed in the plasma of patients, which could potentially be detected by mean of a simple blood test [227]. lncRNA and miRNA are the two classes of non-coding RNAs that have dominated the scene of non-coding molecules in preeclampsia. Other classes of non-coding RNAs have been identified, such as circular RNAs, that appeared recently in the context of PE development and future research will help understand the role of these molecules in the regulation of gene expression and disease [228].
