**5. Conclusions**

The use of STE has shown that the transgenic animal model reflects the changes after preeclamptic pregnancy in a human situation. By applying the state-of-the-art technique STE, especially marginal changes can be detected due to its sensitivity. This will be of paramount importance for future studies on the cause of early cardiac remodeling and the evaluation of potential interventions.

**Author Contributions:** Conceptualization, K.K. and R.D.; Methodology, K.K. and J.O.; Validation, T.S. and O.P.; Formal Analysis, K.K. and A.B.; Investigation, K.K. and J.O.; Data Curation, K.K.; Writing—Original Draft Preparation, K.K.; Writing—Review & Editing, K.K., T.S., J.O., A.B., O.P., F.H., D.N.M., B.T., N.H. and R.D.; Visualization, K.K.; Supervision, R.D.; Project Administration, K.K.; Funding Acquisition, R.D. and B.T. All authors have read and agreed to the published version of the manuscript.

**Funding:** K.K. was funded through a translational Ph.D. project gran<sup>t</sup> by Berlin Institute of Health. B.T. was supported by the European Union's Horizon 2020 research and innovation program under the Marie Skłodowska-Curie gran<sup>t</sup> agreemen<sup>t</sup> No. 765274 – iPlacenta. The Deutsche Forschungsgemeinschaft supported F.H. (HE 6249/5-1).

**Acknowledgments:** We thank Jutta Meisel, Astrid Schiche and Arnd Heuser for their excellent technical assistance. Images in Figure 1 were taken from https://smart.servier.com (Les Laboratoires Servier, Suresnes, France).

**Conflicts of Interest:** The authors declare no conflict of interest.
