**6. Patents**

National Patent Application-Industrial Property Office, Czech Republic (PV 2018-595).

**Supplementary Materials:** Supplementary materials can be found at http://www.mdpi.com/1422-0067/20/3/ 654/s1.

**Author Contributions:** Conceptualization, I.H. and L.K.; methodology, I.H., K.K. and L.D.; software, I.H., K.K., J.S.; validation, I.H., L.K. and J.S.; formal analysis, I.H., K.K.; investigation, K.K., L.D. and J.S.; resources, L.D.; data curation, I.H., K.K. and L.D.; writing—original draft preparation, I.H., K.K. and J.S.; writing—review and editing, I.H. and K.K.; visualization, K.K.; supervision, I.H. and L.K.; project administration, I.H. and L.K.; funding acquisition, I.H. and L.K.

**Funding:** This research was funded by the Agency of Medical Research, Ministry of Health, Prague, Czech Republic, gran<sup>t</sup> number AZV 16-27761A and by the Charles University, Prague, Czech Republic, gran<sup>t</sup> number PROGRES Q34. All rights reserved.

**Acknowledgments:** All procedures were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2000. We thank to the staff of the Institute for the Care of Mother and child (Katerina Hamplova, Katerina Mackova, Radek Cabela and Adam Krasny) for assistance with collection of patients' anamnesis. We also thank to Jana Kumprichtova, Sarka Stranska, Bc. Veronika Marvanova and Bc. Andrea Semencova for assistance with biological sample collection and processing.

**Conflicts of Interest:** The authors declare no conflict of interest.
