**5. Conclusions**

Placental ischemia, a common finding in preeclampsia-complicated pregnancies, leads to increased pro-inflammatory cytokines, increased micro-bleeds, and reduced microglia in proliferative zones of E19 fetal brains. Thus, our findings support the hypothesis that neuroinflammation, micro-vascular damage, and impaired microglia function may partly explain cognitive deficits that occur in offspring of preeclamptic pregnancies.

**Author Contributions:** Study design, J.P.W., G.L.B., and O.C.L.; collection of data, J.P.W., O.C.L., Q.S., and A.B.G.; drafting the manuscript, A.B.G. and J.P.W.; critically reviewing the manuscript, J.P.W., A.B.G., and G.L.B.; approving the final draft of manuscript A.B.G, O.C.L., Q.S., G.L.B., and J.P.W..

**Funding:** This research was funded by a COBRE pilot gran<sup>t</sup> from the National Institutes of Health (P20GM104357) and a K99/R00 award to JPW (HL129192). Fluorescence images were captured using a confocal microscope from the Imaging Core, funded through an Institutional Development Award (IDeA) from the National Institute of General Medical Sciences of the NIH, under gran<sup>t</sup> number P30GM103328. The APC was funded by NIH HL129192.

**Conflicts of Interest:** The authors declare no conflict of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results.
