**About the Editors**

#### **Isabelle Broutin**

Isabelle Broutin is currently the team leader of the group "Membrane transport and signaling" at the university Paris Cite. She is a member of different commissions of trust, such as the direction ´ comity of the doctoral schools MTCI (University Paris Cite), the scientific peer review comity for ´ SOLEIL synchrotron (France), and the local scientific council (CSL) of the faculty of pharmacy.

She followed a formation of physicists at Orsay University, France, before becoming interested in structural biology. After obtaining a Ph.D. in 1993 on the resolution of the 3D structure of a serine collagenase from a cattle parasite, she performed a post-doctoral study in Uppsala, Sweden, on the 3D structure of CRBP. She was recruited in 1997 to the National Center of Scientific Research (CNRS), France, and was involved in the study of cellular signal transduction proteins (Grb2, Grb14, VEGFR, PRLR). She directed the group "signaling and membrane transport" in 2008, and since 2016 she has been Deputy Director of the CiTCoM laboratory, grouping structural biologists with chemists with the common goal to develop therapeutic drugs targeting diseases that are considered major public health problems. Her team works at the comprehension at the molecular level of the mechanistic of the different protein actors involved in antibiotic resistance, with recognized expertise in structural biology of membrane proteins. She has published over 80 manuscripts, book chapters, and reviews, and her recent work has provided important information for the comprehension of the assembly and opening mechanism of RND tripartite efflux pumps, as illustrated by the structure of the MexAB-OprM efflux pump from *P. aeruginosa* (Glavier, Nat Com 2020).

#### **Attilio V Vargiu**

Attilio Vargiu is currently an Assistant Professor of Applied Physics at the University of Cagliari. He obtained his Master's degree in Physics (cum laude) at the same University in 2003. Next, he received a scholarship for a Ph.D. in Statistical and Biological Physics at the International School for Advanced Studies (ISAS/SISSA) in Trieste, obtaining the title in 2008. Between 2008 and 2019, he traveled across Italy (University of Cagliari), Germany (Jacobs University, Bremen), The Netherlands (Utrecht University), and the U.S.A. (University of California, Berkeley) to perform his research. He has almost 20 years of experience in simulating biological macromolecules, peptides, small molecules, membranes, and their assemblies using a large number of advanced computational methods, from quantum-based to coarse-grained to machine-learning-based approaches. In 2010, he published the first study on the main multi-drug transporters involved in microbial resistance to antibiotics. Since then, he has published tens of papers on this subject within an ever-growing network of collaborators in Europe and the U.S. He contributed to setting up a database of conformations and dynamical physicochemical descriptors of antibiotics and other molecules related to microbial research. Since 2015, he broadened his interest to study the self-assembly of peptides for technological and biomedical applications, focusing on the role of chirality in their supramolecular features. Since 2019, he has been developing an algorithm to accurately predict the structures of challenging protein-ligand complexes, as well as exploiting machine learning techniques to identify key molecular descriptors related to antibiotic permeation and to identify native protein–protein complexes.

#### **Henrietta Venter**

Rietie Venter currently leads the Antimicrobial Resistance group in Clinical and Health Sciences at UniSA. Her research focuses on antimicrobial resistance in microbes—one of the most serious threats in healthcare today. The Venter group works on projects targeted at understanding and preventing the development and dissemination of antimicrobial resistance. Rietie is also heading an antimicrobial drug discovery program aimed at finding new therapeutics against drug-resistant pathogens.

Rietie obtained her BSc (Hons) and Master's degrees with distinction from the University of the Free State in South Africa before securing a scholarship to do a Ph.D. in the UK. After completing her Ph.D. at the University of Leeds in the beautiful Yorkshire Dales, she moved to Cambridge, where she spent twelve years conducting research on multidrug transporters, first as a post-doc and later running her own research group as a Royal Society Dorothy Hodgkin Fellow in the Department of Pharmacology. Not content with moving continents once in a lifetime, she left the ancient buildings and immaculate college lawns of Cambridge for the sun and sea in Australia after sixteen years in the UK.

#### **Gilles Phan**

Gilles Phan was trained in chemical biology at University of Orsay and Ecole Normale Superieure Cachan. He gained experience during his Ph.D. at the University of Paris in X-ray ´ crystallography by solving the structure of the membrane channel OprM of the multidrug efflux pump MexAB-OprM from *P. aeruginosa*. In 2008, he extended his expertise in structural biology during his post-doc at Birkbeck College and University College of London, in the group of Pr. Gabriel Waksman, where he worked on the bacterial pili biogenesis of the chaperone-usher pathway. Since 2013, he has been a member of the team of Dr. Isabelle Broutin at CiTCoM lab (Cible Therapeutique ´ et Conception de Medicaments, Paris) as a professor assistant in structural biology and biochemistry, ´ at the School of Pharmacy of Paris. He is now working on the assembly and inhibition strategies of RND efflux pumps and the two-component systems involved in antibiotic resistance.
