*Review* **Research Advances on Health Effects of Edible** *Artemisia* **Species and Some Sesquiterpene Lactones Constituents**

**Antoaneta Trendafilova 1,\*, Laila M. Moujir 2, Pedro M. C. Sousa <sup>3</sup> and Ana M. L. Seca 4,5,\***


**Abstract:** The genus *Artemisia*, often known collectively as "wormwood", has aroused great interest in the scientific community, pharmaceutical and food industries, generating many studies on the most varied aspects of these plants. In this review, the most recent evidence on health effects of edible *Artemisia* species and some of its constituents are presented and discussed, based on studies published until 2020, available in the Scopus, Web of Sciences and PubMed databases, related to food applications, nutritional and sesquiterpene lactones composition, and their therapeutic effects supported by in vivo and clinical studies. The analysis of more than 300 selected articles highlights the beneficial effect on health and the high clinical relevance of several *Artemisia* species besides some sesquiterpene lactones constituents and their derivatives. From an integrated perspective, as it includes therapeutic and nutritional properties, without ignoring some adverse effects described in the literature, this review shows the great potential of *Artemisia* plants and some of their constituents as dietary supplements, functional foods and as the source of new, more efficient, and safe medicines. Despite all the benefits demonstrated, some gaps need to be filled, mainly related to the use of raw *Artemisia* extracts, such as its standardization and clinical trials on adverse effects and its health care efficacy.

**Keywords:** *Artemisia*; clinical trials; health effects; adverse effects; anticancer; antiparasitic; artemisinin; santonin; achillin; tehranolide
