*2.3. Search Strategy*

The investigation method followed the examinations of electronic databases and searches by hand. A search of five electronic databases, including Ovid MEDLINE, PubMed, EMBASE, and Dentistry and Oral Sciences Source, and Biomaterials, for relevant studies published in the English language from February 2010 to September 2017 was carried out.

Digital and searches by hand were then performed in facial bone reconstruction, biomaterials and bone graft scaffold journals from February 2010 to September 2017, including the following: (1) Journal of Craniofacial Surgery; (2) Journal Biomed. Mater. Research A; (3) International Journal of Oral and Maxillofacial Implants; (4) Clinical Oral Implants Research; (5) Implant Dentistry; (6) International Journal of Oral and Maxillofacial Surgery; (7) Journal of Oral and Maxillofacial Surgery; (8) Journal of Dental Research; (9) Biomed. Research International; (10) International Journal of Prosthodontics; (11) Acta Biomaterial.; (12) Journal of Clinical Periodontology; (13) Clinical Implant Dentistry and Related Research; (14) European Journal of Oral Implantology; (15) Facial Plastic Surgery; (16) Materials; (17) Marine Drugs; (18) Biomaterials; (19) Br. J. Oral Maxillofacial Surgery; (20) Aesthetic Plastic Surgery; (21) Ophthal. Plast. Reconstr. Surg.; (22) J. Craniomaxillofacial Surg.; (23) Arch Facial Plast Surg.; (24) Head and Face Medicine; (25) Talanta; (26) Eur. Cell Materials; (27) Mater. Sci. Eng. C Mater. Biol. Appl.; (28) Int. J. Biol. Macromol.; (29) Adv. Food Nutr. Res.; and (30) Macromol. Bioscience. The search was limited to English language articles. In-depth research of the reference lists in the recorded manuscripts was performed in order to add significant studies and to increase the sensitivity of the revision.
