**About the Editors**

#### **Richard E. Frye**

Dr. Richard Frye is a Child Neurologist with expertise in neurodevelopmental and neurometabolic disorders. He received an MD and PhD in Physiology and Biophysics from Georgetown University and a Masters in Biomedical Science and Biostatistics from Drexel University. He completed a residency in Pediatrics at the University of Miami, Residency in Child Neurology and Fellowship in Behavioral Neurology and Learning Disabilities at Children's Hospital Boston and Fellowship in Psychology at Boston University. He holds board certifications in Pediatrics and in Neurology with Special Competence in Child Neurology. He has authored over 200 peer-reviewed publications and book chapters and is currently the Editor-in-Chief for the Section on Mechanisms of Diseases of the *Journal of Personalized Medicine*. Dr. Frye is a national leader in autism spectrum disorder (ASD) research. His studies focus on defining the clinical, behavioral, cognitive, genetic and metabolic characteristics of children with ASD and metabolic disorders and clinical trials demonstrating the efficacy of safe and novel treatments that target underlying physiological abnormalities in children with ASD, including a recent double-blind placebo controlled trial on leucovorin.

#### **Richard G. Boles**

Dr. Richard Boles is the Director of NeuroGenomics at Neurabilities Healthcare. This innovative program uses telemedicine to assist families across the USA, and physicians worldwide, to order, interpret, and act on whole-genome (DNA) sequencing. Dr. Boles also has a private telemedicine practice under the name of Mitochondrial & Molecular Medicine. Additionally, he is a founder and Chief Medical & Scientific Officer of NeuroNeeds LLC, a company dedicated to making food supplement products for people with a variety of neurological, neurodevelopmental, and functional disorders. In the past, Dr. Boles was affiliated with four different clinical laboratories, including being a Medical Director of the genetic testing companies Courtagen and Lineagen. He became involved in genetic testing in order to facilitate the translation of the vast amounts of acquired genetic knowledge into applications that improve routine medical care. Genetic testing remains the focus of his current clinical practice. Dr. Boles is a Clinical Geneticist with expertise in mitochondrial/metabolic, functional (e.g., chronic pain, fatigue, nausea, etc.), and neurodevelopmental disorders. He completed medical school at UCLA, a pediatric residency at Harbor-UCLA, and a genetics fellowship at Yale. He has been board certified in Pediatrics, Clinical Genetics, and Clinical Biochemical Genetics (metabolic disorders). He has authored over 80 peer-reviewed publications, mostly in Mitochondrial Medicine.

#### **Shannon Rose**

Dr. Shannon Rose is an Assistant Professor in the Department of Pediatrics, Division of Allergy/Immunology at the University of Arkansas for Medical Sciences and Arkansas Children's Research Institute in Little Rock, AR, USA. Dr. Rose was trained as a cell biologist and now runs a research program utilizing a combination of novel cell biology and immunology techniques and metabolomics to study mitochondrial and redox biology in health and pediatric metabolic disorders, including autism, obesity and diabetes. She received her PhD in Interdisciplinary Biomedical Sciences at the University of Arkansas for Medical Sciences, under the training of S. Jill James, PhD, and conducted her postdoctoral training at Arkansas Children's Research Institute in the laboratory of Richard E. Frye, MD, PhD. By applying state-of-the-art Seahorse extracellular flux technology to autism to understand the relationship between oxidative stress, environmental exposures, and mitochondrial dysfunction using immune cells, she distinguished subgroups of children with autism with atypical mitochondrial function and increased susceptibility to oxidant-induced dysfunction.

#### **Daniel A. Rossignol**

Dr. Rossignol, MD FAAFP, is a board-certified family physician. He received his Doctorate of Medicine at the Medical College of Virginia and completed his residency in family medicine at the University of Virginia. Coming from an academic background, Dr. Rossignol has a special interest in evidence-based medicine, especially concerning autism spectrum disorder and has published over 70 papers, abstracts, editorials, and book chapters (including those in press) concerning autism and related conditions. Dr. Rossignol has a special interest in autism spectrum disorders, PANS/PANDAS, cerebral palsy, and related neurological and developmental disorders as well as medically complex children and adults. Dr. Rossignol is a Fellow of the American Academy of Family Physicians (FAAFP).
