*3.8. Natural History*

The disease's effects were reversible by stopping CM consumption. In fact, signs and symptoms could last within a time range of 5 to 21 days after the CM withdrawal. Before CM reintroduction, some children showed spontaneous tolerance to pasteurized or boiled CM [4]. Reoccurrence of clinical manifestations was reported with CM reintroduction [3,5,6,10,11,14]. However, it is believed that patients usually definitively outgrow this hypersensitivity, and they can tolerate CM within a few years [11,24,25].
