*2.2. Pru p 3*

Pru p 3 is a non-specific LTP (nsLTP) [17]. The outer surface of the peach (pericarp) has a high concentration of nsLTP [18]. The peel contains seven times higher LTP than the pulp [16]. Pru p 3 cross-reacts with the nsLTP contained in the other fruits of the *Rosaceae* family (apple, plum, cherry and apricot), as well as in vegetables (asparagus, lettuce, tomato, maize, onion, and carrot) and nuts (walnut, hazelnut, almond and peanut) [19]. The LTP nsLTP is a plant panallergen due to its widespread distribution among plant-foods and pollens [16]. The LTPs from different plant-food and pollens can cross-react with each other, causing sensitization and, eventually, symptoms in multiple plant foods, a condition also known as "LTP syndrome" [20]. Pru p 3 is resistant to heat and proteolytic digestion. Therefore, the clinical manifestations of Pru p 3 sensitization can range from mild OAS symptoms to severe systemic allergic reactions (anaphylaxis) [21,22].
