*2.4. Pru p 7*

Pru p 7 is a gibberellin-regulated protein (GRP) [27], also known as Snakin/GASA [28], that was first described by Tuppo et al. in 2013 [27]. Pru p 7 has been found both in the pulp and the peel of the peach [27]. Pru p 7 cross-reacts with several fruits of the *Rosaceae* (i.e., apricot and pomegranate) and *Rutaceae* family (i.e., orange), as well as pollens from the *Cupressaceae* family [29–32]. Indeed, Pru p 7 sensitivity seems to be most common in areas with high cypress pollen exposure [33]. Pru p 7 is resistant to heat and proteolytic digestion [27]. Thus, the typical allergic symptom of Pru p 7 sensitization is anaphylaxis. Similar to Pru p 3, sensitization to Pru p 7 is considered a risk factor for severe allergic reactions to fresh fruit [33]. Biagioni et al. [34] recently reported the first case series of children with documented Pru p 7 allergies and provided a diagnostic algorithm. The authors suggest performing skin prick tests (SPT) for inhalant and food allergens, including both cypress pollen and Pru p 3-enriched peach peel extracts, in case of a systemic allergic reaction to fruit. In cases of a positive SPT for both cypress- and Pru p 3-enriched peach peel extract and a negative in vitro result for specific IgE (sIgE) to Pru p 3, the diagnosis of Pru p 7 allergy is highly probable. In these cases, whenever possible, determining serum sIgE levels of Pru p 7 is recommended.
