*Article* **Nut Allergy: Clinical and Allergological Features in Italian Children**

**Sylvie Tagliati 1,†, Simona Barni 2,†, Mattia Giovannini 2,\*, Giulia Liccioli <sup>2</sup> , Lucrezia Sarti <sup>2</sup> , Tatiana Alicandro <sup>3</sup> , Erika Paladini <sup>4</sup> , Giancarlo Perferi <sup>5</sup> , Chiara Azzari <sup>5</sup> , Elio Novembre <sup>2</sup> and Francesca Mori <sup>2</sup>**


**Abstract:** Background: Nut allergies are an increasingly frequent health issue in the pediatric population. Tree nuts (TN) and peanuts are the second cause of food anaphylaxis in Italy. Unfortunately, knowledge of the clinical characteristics of a TN allergy in Italian children is limited. Our study aimed to identify the clinical and allergological characteristics of Italian children with a nut allergy (TN and peanut). Methods: A retrospective observational analysis was performed on the clinical charts of children with a history of nut reaction referred to the allergy unit of the hospital from 2015 to 2019. The studied population was represented by children with a confirmed nut allergy based on positive prick by prick and/or serum-specific IgE to nut plus a positive nut oral food challenge. Demographic, clinical, and allergological features were studied and compared among different nuts. Results: In total, 318 clinical charts were reviewed. Nut allergy was confirmed in 113 patients. Most patients (85/113, 75%) had a familial history of allergy and/or a concomitant allergic disorder (77/113, 68%). Hazelnut and walnut were the more common culprit nuts observed in allergic children. Anaphylaxis was the first clinical manifestation of nut allergy in a high percentage of children (54/113, 48%). The mean age of the first nut reaction was statistically higher with pine nuts. Over 75% of children reported a single nut reaction. During the OFCs, the signs and symptoms involved mainly the gastrointestinal system (82/113, 73%) and resolved spontaneously in most cases. Severe reactions were not frequent (22/113, 19%). Conclusion: To our knowledge, this is the first Italian study that provided a comprehensive characterization of children with a nut allergy. These results are important for clinicians treating children with a nut allergy.

**Keywords:** children; nut allergy; oral food challenge; peanut; prick by prick; serum specific IgE; skin prick test; tree nut
