*3.2. Course of Chronic Milk-FPIES*

The children were observed from 2 to 6 years of age. The weight deficiency present at the time of chronic milk-FPIES diagnosis regressed in all children by the twelfth month of age. Most of them reached a weight and height range of 25–75 c (48 children, 87%). Hypoproteinemia resolved within 2 months, and the treatment of iron deficiency anemia was usually completed before 6 months of age. Blood count abnormalities resolved within 1–2 months.

The chronic milk-FPIES symptoms in the twelfth month of life were absent in 62% of children, in the nineteenth month—in 78% of children (Table 2). The median duration of treatment with a milk-free diet was 16.8 months (range: 9.3–34.6 mo). After 18 months of observation the three of patients discontinued their participation in the project (they did not report for control milk provocations). After 25 months of age, chronic milk-FPIES symptoms persisted only in one child. They disappeared at the thirty-seventh month of age.

During the 3. OFC and 4. OFC three children showed symptoms of IgE-CMA (Table 2). It was the transition of chronic-milk-FPIES to IgE-CMA.

In the next 2–4 years of follow-up, symptoms of IgE-mediated allergy were found following the ingestion of soya (1 child) and peanuts (2 children) (Table 3). All of them developed extensive urticaria.

At the time of diagnosis, 10 children (18%) had mild atopic dermatitis (AD) (Table 2). By the age of 2, it had resolved in 3 children and by the third year in another 2 children (50%). In the following years, 4 children (7%) developed hay fever and 3 children (5%) developed bronchial asthma (house dust mite allergy).
