*2.3. Pru p 4*

Pru p 4 is a profilin, which is an important pan-allergen, widely found in pollens and vegetables [23]. Pru p 4 is present in the pulp and peel of peach [10]. Pru p 4 cross-reacts with profilins from other members of the *Rosaceae* family (i.e., apple and cherry) and with profilin from unrelated families' pollen (i.e., *Artemisia vulgaris*, *Betula alba*, *Corylus avellanus*, *P amygdalus*) [24]. Pru p 4 is heat-labile and it can be destroyed by gastrointestinal digestion [25]. For this reason, the usual clinical manifestation of Pru p 4 sensitization is OAS [24,26].
