**5. Conclusions**

The findings of the present study demonstrate for the first time that FCP stimulates proliferation, and ameliorates cisplatin-induced cytotoxicity and oxidative stress in TECs. In addition, it was shown that the inhibitory effects of FCP on cytotoxicity are likely associated with suppression of the ROS and MAPK (p38 MAPK, JNK, and ERK) signaling pathways. Therefore, these results sugges<sup>t</sup> that FCP may be a promising protective agen<sup>t</sup> in TEC injury induced by cytotoxicity and oxidative stress elaborated by chemotherapeutic drugs, such as cisplatin and other cytotoxic agents. Furthermore, the data of the current study may provide new insights into the therapeutic approach for the future application of FCP in the prevention and treatment of a variety of the cytotoxic and oxidative stress-mediated injuries in TECs as well as acute or age-related thymic involution.

**Supplementary Materials:** The following supporting information can be downloaded at: https: //www.mdpi.com/article/10.3390/md20040232/s1, Table S1: The primary antibodies used for western blotting in the current study.

**Author Contributions:** Conceptualization, W.H.S., H.-Y.K. and S.Y.; methodology, H.-Y.K., C.L., D.Y.L. and Y.S.L.; validation, S.Y.H.; formal analysis, W.H.S., H.-Y.K., Y.S.L. and S.Y.; investigation, S.Y.H. and S.Y.; data curation, W.H.S., H.-Y.K., Y.S.L. and S.Y.; writing—original draft preparation, W.H.S., H.-Y.K. and S.Y.; writing—review and editing; W.H.S., Y.M., Y.J.S. and S.Y.; project administration, S.Y.; funding acquisition, W.H.S. and S.Y. All authors have read and agreed to the published version of the manuscript.

**Funding:** This work was supported by the National Research Foundation of Korea (NRF) funded by the Korean governmen<sup>t</sup> (MEST) [grant number 2020R1A2C1004529] and [grant number 2021R1F1A1062913].

**Institutional Review Board Statement:** Not applicable.

**Informed Consent Statement:** Not applicable.

**Data Availability Statement:** Not applicable.

**Conflicts of Interest:** The authors declare no conflict of interest.
