*3.8. Statistical Analysis*

The one-way ANOVA statistical test (*p* < 0.05) was used to determine difference among means followed by a Tukey's multiple comparison test (*p* < 0.05) to perform pairwise comparisons. Relative standard deviation (RSD) of resolution values between the target compounds across the high performance countercurrent chromatography (HPCCC) separation was estimated. The data were analyzed using the Statistical Package S-Plus 2000.

**Supplementary Materials:** The following are available online at https://www.mdpi.com/article/10 .3390/md19090517/s1, Figure S1: Growth curve of *Phaeodactylum tricornutum*.

**Author Contributions:** Conceptualization, J.C. and D.B.-P.; methodology, J.C. and D.B.-P.; formal analysis, D.B.-P., P.H., J.K., A.S., P.J.F.-M., M.B. and A.S.-R.; investigation, D.B.-P.; writing—original draft preparation, D.B.-P. and J.C.; writing—review and editing, P.H., J.K. and A.S.; supervision, J.C.; funding acquisition, P.H. All authors have read and agreed to the published version of the manuscript.

**Funding:** This research was funded by the Technology Agency of the Czech Republic (NCK gran<sup>t</sup> TN010000048/03, J.C., D.B-P., P.H. and A.S.) and the National Programme of Sustainability I of the Ministry of Education, Youth and Sports of the Czech Republic (ID: LO1416, JC, PH, JK). Biotests were funded by the IMDEA Food Institute, the Ramón Areces Foundation (CIVP18A3891) and a Ramon y Cajal Fellowship (MICINN, RYC-2017-22335).

**Acknowledgments:** Daniela Bárcenas-Pérez gratefully acknowledges the research supervision of José Cheel (Centre Algatech–Czech Academy of Sciences) during the doctoral study as well as the University of South Bohemia for a doctoral scholarship and the gran<sup>t</sup> GAJU 017/2019/P. The authors thank Alastair T. Gardiner for English proofreading of the article and Wolfgang Link for kindly providing the FOXO3-GFP construct.

**Conflicts of Interest:** The authors declare no conflict of interest.
