*3.4. Statistical Analysis*

The data are expressed as the means ± standard error of the mean (SEM). Statistical differences were determined via one-way ANOVA followed by the Tukey test at *p* < 0.05.

**Author Contributions:** K.N. performed the experiments. N.T. and F.B. gave helpful suggestions for the animal experiment and the analysis of fucoxanthin metabolites. A.A., E.T., T.F. and M.O. discussed the study and prepared the samples. M.H. designed the experiments and wrote the paper. All authors have read and agreed to the published version of the manuscript.

**Funding:** This work was supported by Taiyo Kagaku Co., Ltd.

**Institutional Review Board Statement:** All procedures for animal care in this study were approved by the Ethical Committee of Experimental Animal Care of Hokkaido University (No 19-0083, 3 July 2019).

**Informed Consent Statement:** Not applicable.

**Data Availability Statement:** Not applicable.

**Conflicts of Interest:** This study was funded by Taiyo Kagaku Co., Ltd. (Mie, Japan). Monocaprin was provided from Taiyo Kagaku Co., Ltd. Additionally, A.A., T.E., F.T. and O.M. are employees of Taiyo Kagaku Co., Ltd.
