*4.8. Statistical Analysis*

All experiments were performed at least three times, and data are presented as mean ± SEM. Continuous variables were compared using Mann–Whitney U test. For doseresponse analyses, the nonparametric Jonckheere–Terpstra trend test was performed. All data were analyzed using STATA® SE, version 15.0 (StataCorp LLC, College Station, TX, USA). A *p* value < 0.05 was considered statistically significant.
