2.2.4. Immunomodulatory Activity

In immunomodulation, regulating many immune cells through signaling molecules to enhance the immune system, is necessary. Based on previous studies, several marine metabolites have been reported to have regulatory effects on the immune system [33]. Fucosterol is one of the compounds that is regarded as a candidate immunomodulator, as reported by Park et al. [34] in vitro and in vivo; fucosterol from *Sargassum fusiforme* can increase the secretion of tumor necrosis factor alpha (TNFα), NO production, and phagocytosis activity. Generally, fucosterol has the potential to regulate immune function and may offer positive therapeutic effects in immune system diseases.
