2.2.3. Anti-Osteoarthritis Activity

The anti-osteoarthritis activity of fucosterol has been demonstrated both in vitro and in vivo [21,31,32]. Anti-osteoarthritis is a biological activity characterized by the ability of a compound to reduce or prevent bone disease. *Sargassum fusiforme*-derived fucosterol has been shown to increase proliferative activity in osteosarcoma MG63 cells for the treatment of bone-absorbing metabolic bone diseases, including osteoporosis and periodontitis [21]. Similar results were observed in ovariectomized rat osteoporosis and fucosterol of *Sargassum fusiforme* triggered bone regeneration and activation of bone formation [31], and Bang et al. [32] tested fucosterol in vitro and reported that fucosterol from *Undaria pinnatifida* inhibited osteoclast differentiation. Through this biological activity, fucosterol may play an important role in preventing osteoporosis and may be useful as a supplement.
