**Application of Microalgal Stress Responses in Industrial Microalgal Production Systems**

**Jia Wang 1, Yuxin Wang 1, Yijian Wu 2, Yuwei Fan 1, Changliang Zhu 1, Xiaodan Fu 3, Yawen Chu 4, Feng Chen 5, Han Sun 1,\* and Haijin Mou 1,\***


**Abstract:** Adaptive laboratory evolution (ALE) has been widely utilized as a tool for developing new biological and phenotypic functions to explore strain improvement for microalgal production. Specifically, ALE has been utilized to evolve strains to better adapt to defined conditions. It has become a new solution to improve the performance of strains in microalgae biotechnology. This review mainly summarizes the key results from recent microalgal ALE studies in industrial production. ALE designed for improving cell growth rate, product yield, environmental tolerance and wastewater treatment is discussed to exploit microalgae in various applications. Further development of ALE is proposed, to provide theoretical support for producing the high value-added products from microalgal production.

**Keywords:** adaptive laboratory evolution; microalgal production; environmental tolerance
