*4.3. Sequence Logos and Structure Model Analysis*

Sequence logos for the A20 domain in 26 *MdSAP* genes and the AN1 domain in 28 *MdSAP* genes were generated by the application WebLogo (http://weblogo.threeplusone.com) (Supplementary Sequences A3 and A4). We used the web server SWISS-MODEL (http://swissmodel.expasy.org/) for modeling and predicting the homology of protein structures for those two domains [46]. The proposed 3D structure was modeled on the original NMR structure in PDB ID: 2KZY and 1WFP, and RasTop 2.2 software (http://www.geneinfinity.org/rastop/) was used to present that model [47].
