*2.10. Statistical Analysis*

An estimating equations (GEE) test was used to evaluate significant differences in all in vitro experiments except for apoptosis assay in which Two-way ANOVA was used. The Kruskal-Wallis test was performed with the post hoc Dunn's multiple comparisons to evaluate significant differences in the growth rate of xenografts between treatment groups. All analyses were performed using the IBM SPSS Statistics software application (version 24: IBM, Armonk, NY, USA). Excluding MTT analysis, all results are shown as means ± SE. *p* < 0.05 was considered to indicate statistical significance.
