*3.4. Adverse Effects*

T21 participants were also encouraged to report any adverse side effects that they considered associated with the treatment with CBPMs. Inhalation of THC-predominant flower was found in general to be safe. Only two participants diagnosed with chronic pain reported minor adverse side effects associated with KHIRON 20/1 from those available in the list: (i) a 42-year-old male with previous experience with cannabis who medicated several times a day reported suffering a "mild headache" which remitted after 1–2 h; and (ii) a 32-year-old female reported suffering "memory loss". This adverse effect was described by the patient as "transient" and "not relevant". Of note, this participant was among the 15 patients (4.4% of total cohort) that were naïve to cannabis prior to enrolling in project T21.
