*2.2. Drugs*

Cannabidiol (CBD) and Δ9-tetrahydrocannabinol (THC) were purchased from Cayman Chemical (Ann Arbor, MI, USA). CBD extract was produced through supercritical CO2 extraction from hemp (Helping Hands Hemp, Womelsdorf, PA, cultivar: YoungSim 10) and THC extract was provided by the NIDA drug program (Research Triangle Institute, Research Triangle Park, NC, USA) the composition of both was verified by an independent laboratory (Keystone State Testing, Harrisburg, PA, USA) Cisplatin was purchased from Acros Organics (Fairlawn, NJ, USA).

#### *2.3. Supercritical CO2 Extraction*

Dried hemp flower, 500 g, was ground and then extracted using supercritical CO2 in an extractor from Supercritical Fluid Technologies (CannabisSFE, Newark, DE, USA). Extraction was performed at 55 ◦C, with 413 bars of pressure for 30 min. Extract was collected and dissolved in ethanol to a concentration of 10% extract in 90% ethanol by weight and incubated at −20 ◦C for 24 h (winterization). The solution was then filtered and ethanol was evaporated. The extract was then resuspended in fractionated coconut oil (Pure Body Naturals, West Chester, OH, USA) at 200 mg/mL and heated to 95 ◦C for 1 h to decarboxylate the cannabinoids.
