*Review* **The Therapeutic Potential of the Endocannabinoid System in Age-Related Diseases**

**Ivona Maria Tudorancea 1, Mitică Ciorpac 1, Gabriela Dumitrit,a Stanciu 1, Cătălin Caratas,u 1, Alina Săcărescu 2,3, Bogdan Ignat 4, Alexandra Burlui 5,6, Elena Rezus, 5,6, Ioana Creangă 1,7, Teodora Alexa-Stratulat 7,8, Ionut , Tudorancea 9,10,\* and Bogdan Ionel Tamba 1,11**


**Abstract:** The endocannabinoid system (ECS) dynamically regulates many aspects of mammalian physiology. ECS has gained substantial interest since growing evidence suggests that it also plays a major role in several pathophysiological conditions due to its ability to modulate various underlying mechanisms. Furthermore, cannabinoids, as components of the cannabinoid system (CS), have proven beneficial effects such as anti-inflammatory, immunomodulatory, neuromodulatory, antioxidative, and cardioprotective effects. In this comprehensive review, we aimed to describe the complex interaction between CS and most common age-related diseases such as neuro-degenerative, oncological, skeletal, and cardiovascular disorders, together with the potential of various cannabinoids to ameliorate the progression of these disorders. Since chronic inflammation is postulated as the pillar of all the above-mentioned medical conditions, we also discuss in this paper the potential of CS to ameliorate aging-associated immune system dysregulation.

**Keywords:** cannabinoids; aging; endocannabinoid system; cannabinoid receptors; age-related diseases
