*2.1. Animals*

All experiments were conducted in a manner approved by the Pennsylvania State University, College of Medicine Institutional Animal Care and Use Committee (IACUC). Male (*n* = 120) and female (*n* = 120) age-matched (10–12 weeks) wild-type C57BL/6 mice (The Jackson Laboratory, Bar Harbor, ME) were used in this study. All mice were grouphoused with a 12 h light/dark cycle with access to food and water ad libitum.
