*2.9. Statistical Analysis*

Data were collected in individual animals and are presented in bar graphs as means of 8 independent determinations ± standard errors (SEM). Shapiro −Wilk and the Kolmogorov-Smirnov tests were employed to determine normality of residuals (see Supplementary Tables S1–S4). Molecular results from the single CBD treatment as well as CBD content measurements in plasma and mPFC and mRNA and protein level determinations, normally distributed, were analyzed by ordinary one-way ANOVA followed by Tukey's post-hoc test, or for repeated CBD treatments by unpaired Student's *t*-test. Data with a non-normal distribution were analyzed by the Kruskal −Wallis one-way ANOVA for ranks followed by Dunn's multiple comparisons test, or by the Wilcoxon −Mann −Whitney test. Outlier calculation was performed with Grubb's test on the free platform GraphPad by Dotmatics. Statistical significance was assumed at *p* < 0.05.
