*2.1. Materials*

To closely mimic human THC consumption, we used a formulation of THC (3.62% THC, 6.47% tetrahydrocannabinolic acid (THCA), a total of 101 mg/ml of THC) with a minimal content of terpenes (β-myrcene 0.06%, β-caryophyllene 0.64%, humulene 0.39%; a total of 1.09% terpenes) dissolved in Polyethylenglycol (PEG 400), designed for use with a commercially available vaporization apparatus.

PEG 400 with terpenes was used as the vehicle for the control group. Connecticut Pharmaceutical Solutions, LLC, Portland, CT, USA (a state-licensed grower) provided the compounds through the Connecticut Medical Marijuana Research Program.
