*2.7. Statistical Analysis*

Data were analyzed using GraphPad Prism 8 (version 8.0.1, GraphPad Software Inc., San Diego, CA, USA). Differences in survival curves were tested using the log-rank test (Mantel-Cox). Kolmogorov–Smirnov tests were performed on each set of data to determine whether it had a normal distribution. Non-normally distributed data was analyzed with a Mann–Whitney test; otherwise, an unpaired t test was used. For matched observations, a two-way ANOVA with Sidak's multiple comparison test was used. The mixed-effect model with Geisser–Greenhouse correction was used in case of missing values. An alpha value of 0.05 was used as the cutoff for significance.
