*2.7. Statistical Analyses*

The impact of treatment on sleep was assessed using the change in CSHQ scores in each treatment period. Difference in the CSHQ total score was assessed both as a continuous and a dichotomous variable, using the cutoff score of 41. We adjusted for the following variables: sex, age at enrollment, and maternal education.

Continuous variables were assessed by two-tailed paired t-tests or ANOVA (after confirmation for normal/near normal distribution). Categorical variables were assessed by Pearson χ2 test. Treatment efficacy was compared between groups during the first and second treatment period and within treatment groups for participants who completed both treatment periods (per protocol [PP] analysis). Analyses were performed using IBM SPSS® version 25 (2017). All *p* values were two-sided. *p*-value < 0.05 was considered significant.
