**5. Conclusions**

This review showed that the zebrafish may prove a useful model for cannabinoid translational research because it displays similar behaviors to rodents following cannabinoid exposure. Moreover, it is clearly necessary to pay more attention to the full spectrum of naturally occurring cannabinoids, rather than focusing on the main ones: THC and CBD. These results indicate a need for additional cannabis-based studies to shed light on the mechanistic properties of cannabinoids, and to provide insight into the potential risks of its therapeutic application. At the same time, it is necessary to consider the long-term consequences of early-life exposure to cannabinoids.

**Author Contributions:** Conceptualization, R.L.; methodology, R.L. and V.N.; software, R.L.; investigation, R.L., V.N., M.M. (Maria Marchese), and A.O.; resources, M.M. (Maria Marchese) and M.M. (Marco Martinelli); data curation, R.L. and A.O.; writing—original draft preparation, R.L.; writing— review and editing, R.L., V.N., M.M. (Maria Marchese), A.O., C.K., and F.M.S.; visualization, M.M. (Marco Martinelli); supervision, B.F. and F.M.S.; project administration, R.L.; funding acquisition, B.F. and F.M.S. All authors have read and agreed to the published version of the manuscript.

**Funding:** This research was funded by the Italian Ministry of Health, Ricerca Corrente 2021, Fondo 5X1000.

**Institutional Review Board Statement:** Not applicable.

**Informed Consent Statement:** Not applicable.

**Data Availability Statement:** Not applicable.

**Acknowledgments:** We are thankful to Catherine J. Wrenn for the expert text editing and advice.

**Conflicts of Interest:** The authors declare no conflict of interest.
