*2.5. Statistical Analysis*

Demographics are expressed either as percentage or as the mean ± standard deviation. Results of PROMS analysis are represented in box and whisker graphs, which indicate upper and lower extreme values, median, upper quartile, and lower quartile. Statistical analyses were performed by either student's t (comparisons of means at t = 0 and t = 3) or one-way ANOVA (comparisons of means at t = 0, t = 3 and t = 6) followed by Friedman non-parametric test and pair-wise comparisons (Durbin-Conover) using the Jamovi free software V2.2.2 (San Francisco, CA, USA). Post hoc analyses were considered statistically significant if *p* < 0.05.
