3.1.5. Water T-Maze

For the WTM, tested on days 28–29 (Figure 1e), a repeated measures ANOVA (shock × drug × test; 2 × 2 × 2) revealed significant effects of shock [F(1,35) = 60.717, *p* < 0.001], drug [F(1,35) = 77.881, *p* < 0.001] and test [F(1,35) = 13.271, *p* < 0.01], with a significant shock × drug interaction [F(1,36) = 53.689, *p* < 0.01]. Post hoc analysis revealed that the Shock/Veh group showed a significant increase in the number of trials required to reach the criterion in both phases compared with the NoShock/Veh and Shock/URB groups (for both groups: acquisition, *p* < 0.01; reversal, *p* < 0.001). This suggests that URB597 prevented the shock and reminders-induced impairment in performance in the WTM task.

#### 3.1.6. Forced Swim Test

For the FST, performed on days 30–31 (Figure 1f), a two-way ANOVA [shock × drug; 2 × 2] on immobility revealed significant effects of drug [F(1,36) = 6.047, *p* < 0.05], and drug × shock interaction [F(1,36) = 7.389, *p* < 0.05]. Post hoc analysis revealed an increase in immobility in the Shock/Veh group compared with the NoShock/Veh group (*p* < 0.05) and the Shock/URB597 group (*p* < 0.01), suggesting that URB597 restored the shock- and reminders-induced despair-like behavior.
