3.3.4. Safety Profile

Mangiferin in high concentrations may cause damage to the mitochondrial respiratory chain, since free radicals are also needed for normal cellular activity [131]. The oral administration of 0.9 g of mangiferin has been reported to be harmless to adults [131,149]. Mangiferin per se did not have any adverse reports in VigiBase [95]; otherwise, *Mangifera indica* has 62 reports of unwanted effects, entirely from the Americas [95]. The side effects were mainly gastrointestinal (nausea and diarrhea), nervous system (dizziness) and skin (pruritus and erythema) disorders [95]. Overall, at moderate doses, the compound has been reported to be safe for humans.
