**4. Conclusions**

In short, the data evidenced that pomegranate peel is a valuable raw material rich in bioactive compounds. The amount and the type of bioactive compounds depends on the cultivars, but more so on the area where the plant grows.

Same cultivars grown in different conditions can have different amounts and varieties of phenolic compounds and diverse antioxidant activities, evidencing that the pedoclimatic variables drive the metabolism of the cultivars, increasing or decreasing specific secondary metabolites implicated in physiological adjustment of plants to adapt to stress conditions or changing conditions induced by climate. In addition, the spray-drying system developed by Gioia Succhi is innovative because it is able to perfectly concentrate and conserve the bioactive compounds with beneficial effects on human health in respect to the freezedrying system, which has been already demonstrated by numerous studies to be much more relevant than the oven-drying procedure (40–60 ◦C). According to the achieved results, the high antioxidant capacity of pomegranate peel, exalted by the innovative method of drying, highlights its use as a supplement to preserve human health from various diseases. The innovative spray-drying method appears to be advantageous from an economic point of view, as it is able to condense the bioactive compounds considerably, providing a concentrated peel powder ready to be used in the nutraceutical field.

**Author Contributions:** F.M.: formal analysis; B.P.: methodology, formal analysis; F.C.: formal analysis; A.M. (Angela Maffia): statistical analysis; C.M.: formal analysis; A.M. (Adele Muscolo): project administration, funding acquisition, writing—original draft, writing—review and editing. All authors have read and agreed to the published version of the manuscript.

**Funding:** This research received no external funding.

**Institutional Review Board Statement:** Not applicable.

**Informed Consent Statement:** Not applicable.

**Conflicts of Interest:** The authors declare no conflict of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results.

**Sample Availability:** Samples of the compounds are available from the authors.
