*3.2. Protective Effect of R. conduplicans AE and Isolated Compounds on Oxidative DNA Damage*

The Fenton's reaction produces the hydroxyl radical, which is a ROS that is detrimental to the human body. Hydroxyl radicals react with different nucleobases, thereby inducing the formation of mutated bases that eventually lead to DNA damage [32]. Figure 5 demonstrated that FR damaged DNA significantly (*p* < 0.001) compared to the control (DMSO + DNA). Though all compounds showed significant protection against hydroxyl radical-induced DNA damage (*p* < 0.001, cpd **10**: *p* < 0.05), compound **14** could not prevent the oxidative damage to DNA (Figures 5 and S49). The genoprotective activity of these compounds and the AE may be attributed to the presence of free radical scavenging potential.
