*4.8. Statistical Analysis*

All experiments were repeated at least three times and the data were expressed as mean ± standard deviation. SPSS 19.0 software was used in statistical analysis. Significance was determined using the one-way or two-way ANOVA test with a post hoc multiple comparison test. Meanwhile, the IC50 and combination index values were calculated using Graphpad prism version 8.0.2 and Compusyn software.
