*4.2. Distribution*

The apparent volume of distribution (measured by the Vss value) of PTS (Vss = 5.3 L/kg) following intravenous dosing in rats was greater than that of the total body water (Vss = 0.7 L/kg), indicating substantial tissue distribution [4]. The distribution of PTS has been found in the liver, kidney, heart, lungs, and brain [27]. The primary metabolites of PTS are the sulfate and glucuronide conjugates [4]. After intravenous administration in male rats, sulfate conjugates seem to be more extensive than glucuronide conjugates [4]. After 1–2 h of oral administration, the entero-hepatic recycling of the metabolite with an increased concentration of glucuronidated PTS was reported [2,28].
