*Review* **Phenolic Compounds' Occurrence in** *Opuntia* **Species and Their Role in the Inflammatory Process: A Review**

**Walid Zeghbib 1,2, Fares Boudjouan 3,4, Vitor Vasconcelos 2,5 and Graciliana Lopes 2,\***


**Abstract:** Within the *Cactaceae* family, *Opuntia* comprises the most widespread species, with a recognized importance in human life, including feeding, domestic use as home natural barriers, and as a traditional remedy for diverse diseases and conditions such asthma, edema, and burns. Indeed, scientific reports have stated that these health benefits may be due to various active compounds, particularly polyphenols, which are ubiquitously found in plants and have proven their pharmacological efficiency by displaying antimicrobial, anti-cancer, and anti-inflammatory activities, among others. *Opuntia* species contain different classes of phenolic compounds that are recognized for their anti-inflammatory potential. Among them, quercetin, isorhamnetin, and kaempferol derivates were reported to greatly contribute to modulate cells' infiltration and secretion of soluble inflammatory mediators, with key implications in the inflammatory process. In this review, we make a summary of the different classes of phenolic compounds reported in *Opuntia* species so far and explore their implications in the inflammatory process, reported by in vitro and in vivo bioassays, supporting the use of cactus in folk medicine and valorizing them from the socio-economic point of view.

**Keywords:** *Opuntia* sp.; prickly pear; phenolic compounds; flavonoids; inflammation
