**5. Conclusions**

Adlay testa exhibits antiglycative activities that affect protein glycation and the protein's subsequent crosslinking. Adlay inhibits glycation, perhaps mainly due to its antioxidant phenolic acid compounds of chlorogenic acid and ferulic acid. Therefore, adlay seeds may be a potential candidate for the future development of alternative therapeutics for AGE-related diseases.

**Author Contributions:** Conceptualization, S.-M.H., C.-P.C., W.-S.C., D.-W.H., W.-C.C. and C.-H.W.; experimentation, W.-S.C., C.-P.C., D.-W.H., M.-Y.L. and C.-H.W.; data analysis and figure preparation, S.-M.H., C.-P.C., W.-S.C., D.-W.H. and C.-H.W.; methodology and resources, C.-P.C., W.-S.C., D.-W.H., W.-C.C., M.A., M.-Y.L. and C.-H.W.; writing—original draft preparation, W.-S.C. and C.-H.W.; writing—review and editing, C.-H.W.; editing and approval of the final version of the manuscript, S.-M.H. and C.-H.W. All authors have read and agreed to the published version of the manuscript.

**Funding:** This study was supported by grants MOST106-2311-B-003-006 from the Ministry of Science and Technology, ZRRPF3M0081 from the Research Center for Food and Cosmetic Safety, and ZRRPF3L0091 and ZRRPF3M0091 from the Research Center for Chinese Herbal Medicine, Chang Gung University of Science and Technology.

**Institutional Review Board Statement:** Not applicable.

**Informed Consent Statement:** Not applicable.

**Data Availability Statement:** Data are contained within the article.

**Conflicts of Interest:** The authors declare no conflict of interest.

**Sample Availability:** Samples of the crude extracts prepared from adlay seed are available from the authors.
