Reprint

The Structural and Functional Study of Efflux Pumps Belonging to the RND Transporters Family from Gram-Negative Bacteria

Edited by
April 2022
190 pages
  • ISBN978-3-0365-3946-1 (Hardback)
  • ISBN978-3-0365-3945-4 (PDF)

This is a Reprint of the Special Issue The Structural and Functional Study of Efflux Pumps Belonging to the RND Transporters Family from Gram-Negative Bacteria that was published in

Biology & Life Sciences
Medicine & Pharmacology
Summary

Antimicrobial-resistant bacterial infections are a major and costly public health concern. Several pathogens are already pan-resistant, representing a major cause of mortality in patients suffering from nosocomial infections. Drug efflux pumps, which remove compounds from the bacterial cell, thereby lowering the antimicrobial concentration to sub-toxic levels, play a major role in multidrug resistance. In this Special Issue, we present up-to-date knowledge of the mechanism of RND efflux pumps, the identification and characterization of efflux pumps from emerging pathogens and their role in antimicrobial resistance, and progress made on the development of specific inhibitors. This collection of data could serve as a basis for antimicrobial drug discovery aimed at inhibiting drug efflux pumps to reverse resistance in some of the most resistant pathogens.

Format
  • Hardback
License and Copyright
© 2022 by the authors; CC BY-NC-ND license
Keywords
MdtF (YhiV); multidrug resistance; RND-type efflux pump; dye accumulation; real-time efflux; pathogens; multidrug resistance; RND; evolution; efflux pump; adaptation; Aliarcobacter butzleri; RND efflux pumps; virulence; resistance; RND pump; dominant negative effect; assembly; protein-protein interaction; mutation; RND efflux pumps; drug resistance; cystic fibrosis; RND efflux pumps; prevalence of efflux resistance mechanisms; hospital acquired infections; antibiotic resistance; efflux pump; RND; allostery; antimicrobial resistance; conformational changes; efflux pump; energetic transition; gram-negative bacteria; pump activation; antibiotic resistance; efflux pump; RND; n/a