Persistent Childhood Asthma: 2nd Edition

Dear Colleagues,

Asthma is the most common chronic disease in children and a cause of great distress for both children and their families. Various overlapping phenotypes exist, complicating aligned research in the field and meaningful, personalized treatment of the disease. Young children are particularly diverse with numerous and variable phenotypic presentations in early life that correspond to different outcomes. Despite the high reported rates of remission of asthma, the disease is usually considered as treatable but not curable once present. Understanding of the determinants that affect the course of diagnosed asthma, e.g., the avoidance of environmental or occupational exposures, is therefore important for tertiary prevention, since asthma persistence is associated with frequent and severe symptoms and with the development of impaired lung function. Asthma treatment guidelines have proven useful in standard care and the reduction in adverse outcomes in patients with asthma; however, the phenotypic heterogeneity within the disorder indicates the need for personalized medicine as opposed to a one-size-fits-all treatment approach.

The goal of this Special Issue is to provide an improved understanding of the phenotypes of persistent asthma (prevalence, comorbidities, lung function, response to treatment, etc.) and also to investigate the impact of genetic and environmental exposures in order to elucidate the possibility of tertiary prevention.

Dr. Ann-Marie Malby Schoos
Guest Editor

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• asthma
• children
• phenotypes
• persistence
• remission
• severity
• lung function
• treatment
• tertiary prevention
• comorbidities
• exposures
• genetics
• epigenetics