Genetics, Epigenetics and Molecular Therapies of Autoimmune Diseases
A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Human Genomics and Genetic Diseases".
Deadline for manuscript submissions: 25 November 2024 | Viewed by 84
Special Issue Editor
Interests: epigenomics of cancers; type 1 diabetes; multiple sclerosis; immunoregulation of cancers; autoimmune diseases
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Autoimmune diseases are chronic, debilitating conditions that affect 5–8% of the population regardless of ethnicity. Approximately 100 diseases have been documented as directed against the human body due to a breach in self-tolerance. Women are disproportionately impacted by these diseases. While some autoimmune diseases, including thyroiditis, rheumatoid arthritis, type 1 diabetes, and multiple sclerosis, are directed against specific organ systems, others like lupus impact various organ systems. All autoimmune diseases are genetically inherited, and the genes that render individuals susceptible to specific disorders remain to be fully elucidated. The manifestation of diverse autoimmune diseases, polyautoimmunity, in individuals is not uncommon. Another complexity is that the genes involved in manifesting autoimmune disorders are often modulated by various epigenetic mechanisms and are poorly understood. Given these complexities, finding a specific treatment for many autoimmune diseases has been difficult. This Special Issue aims to compile novel data on the genetic and epigenetic mechanisms involved in various autoimmune disorders, and the potential molecular therapies to treat these disorders are of significant interest.
Dr. Sundararajan Jayaraman
Guest Editor
Manuscript Submission Information
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Keywords
- autoimmune disease
- type 1 diabetes
- multiple sclerosis
- epigenetic
- genetic
- molecular therapies
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