Genetics-Epigenetics Crosstalk in Diseases and Host-Parasite Relationships
A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Human Genomics and Genetic Diseases".
Deadline for manuscript submissions: 25 January 2025 | Viewed by 94
Special Issue Editors
Interests: (epi)genetic susceptibility to complex diseases; immunogenetics; nutrigenetics; pharmacogenetics
Special Issues, Collections and Topics in MDPI journals
Interests: malaria; Plasmodium falciparum; filariasis; COVID-19
Interests: epigenetics; DNA methylation; cancer; stress
Interests: human skin organ culture; inflammation; pemphigus; wound healing
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The genome can be understood in general terms as an RNA factory whose fine regulation depends strictly on the epigenetic mechanisms that translate environmental signals into genetic expression with adaptive value. However, the signals given by parasites often hijack epigenetic mechanisms aimed at homeostasis, changing gene expression for their own advantage and ensuring the propagation of the cycle. Some genetic alleles can further strengthen the infectious process. Together with epivariants, they often initially bias the host's immune response toward tolerance to the parasite, later causing irreversible tissue destruction, especially in well-established parasite–host relationships. Stressful events in the host's life increase the basal production of key proinflammatory factors and further fuel the rate of inflammation, rapidly reaching a tipping point beyond which there is no return. For this collection, we invite submissions of original papers, systematic reviews, and perspective articles (narrative review associated with original results, launching new hypotheses) that take on the challenge of untangling the tight knots that maintain parasitic cycles across generations of host and vector species.
Dr. Angelica Beate Winter Boldt
Dr. Olusola Ojurongbe
Dr. Sheila Coelho Soares-Lima
Prof. Dr. Jennifer Elisabeth Hundt
Guest Editors
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Keywords
- epigenetics
- gene polymorphisms
- evolution
- parasite
- immunogenetics
- metabolism
- behaviour
- host–parasite coevolution
- infection
- inflammation
- genetic resistance
- neglected infectious diseases
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