Developmental Biology and Genetics in Animal Embryo
A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Molecular Genetics and Genomics".
Deadline for manuscript submissions: closed (20 December 2024) | Viewed by 178
Special Issue Editor
Special Issue Information
Dear Colleagues,
Mammalian embryo development encompasses the developmental stages from fertilization to implantation in the mother’s uterus, including maternal-to-zygotic transition, zygotic genome activation, and formation of the blastocyst. During early embryo development, the transcriptionally inactive egg completes its second meiotic division, and the zygote, which contains separate haploid paternal and maternal pronuclei, is formed. Upon DNA replication and pronuclear syngamy, the totipotent zygote undergoes a series of cleavage divisions that will eventually result in the formation of the blastocyst, which contains pluripotent cells.
During early embryo development, important epigenetic changes occur to ensure correct progression of the development. For example, the embryos undergo global DNA demethylation, remodeling of histone methylation, dynamic changes in noncoding RNA, and RNA methylation. Although some of these changes are well documented, many of them remain unclear. In the Special Issue, we will discuss the epigenetic regulation of the early embryo development in mammals.
Dr. Mingtian Deng
Guest Editor
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Keywords
- embryo development
- maternal genes
- zygotic genome activation
- epigenetic modification
- RNA methylation
- histone methylation
- noncoding RNA
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