Unveiling Human Microbiome Composition and Functions to Improve Health and Disease Research
A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Microbial Genetics and Genomics".
Deadline for manuscript submissions: 25 October 2025
Special Issue Editor
2. CEINGE-Biotecnologie Avanzate Franco Salvatore, Napoli, Italy
Interests: next generation sequencing; genomics; cancer genomics; hereditary cancers; metagenomics; human microbiome; molecular diagnostics
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The human microbiome, an intricate ecosystem of microorganisms residing in and on the human body, has emerged as a cornerstone of biomedical research over the past decade. With advances in sequencing technologies and computational biology, we have begun to uncover the profound influence of the microbiome on virtually every aspect of human health and disease. From metabolic and immune system regulation to its role in neurological and psychological well-being, the microbiome offers unprecedented opportunities to understand the complex interplay between humans, and in particular human genes, and their microbial counterparts.
This Special Issue, "Unveiling Human Microbiome Composition and Functions to Improve Health and Disease Research", is dedicated to exploring the genetic underpinnings of microbiome functions and their integration with host genomics. This Special Issue highlights cutting-edge methodologies, tools, and conceptual frameworks that leverage the microbiome to address critical challenges in health research and clinical practice. As the field continues to evolve, researchers are employing innovative strategies to interrogate microbiome composition and function, establish causal relationships, and develop targeted interventions.
The articles in this Special Issue should cover the diverse range of approaches—from in vitro and in vivo models to advanced computational techniques and translational applications—with a strong emphasis on genetic and genomic perspectives. Collectively, they will emphasize the importance of interdisciplinary collaboration, integrating microbiology, bioinformatics, immunology, and clinical sciences to propel our understanding of microbiome-mediated mechanisms and their implications for health and disease management.
This introduction highlights the importance of harnessing the human microbiome to revolutionize healthcare. By fostering dialogue across disciplines and embracing the complexity of host–microbe interactions, we aim to illuminate pathways for precision medicine and transformative public health initiatives. We invite you to delve into this Special Issue and join us in exploring the exciting frontiers of microbiome research. Research and review articles on these aspects are encouraged. The manuscripts will, as always, be subjected to examination by specialized reviewers to guarantee their scientific acceptability.
Dr. Valeria D’Argenio
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Genes is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- human microbiome
- health and disease
- precision medicine
- host–microbe interactions
- translational research
- metagenomics
- multi-omics approaches
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