Genetic and Genomic Approaches to Human Aging
A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Human Genomics and Genetic Diseases".
Deadline for manuscript submissions: 15 January 2025 | Viewed by 104
Special Issue Editor
Special Issue Information
Dear Colleagues,
The involvement of genetic mechanisms in human aging has been studied since the advent of geroscience as a field. In addition to the known roles of many individual genes, such as Igf1r, Apoe, and Sirt1, in the aging process, telomere shortening, epigenetic alterations, and genomic instability have been long established as hallmarks of aging.
The advent of modern genetic and genomic techniques, including next-generation sequencing, genome-wide association studies, and CRISPR-Cas9 gene editing, have allowed researchers to investigate the role of genes, mutations, and gene expression regulation in aging in greater depth than ever before. Recent advances in the use of transcription factors to reprogram aged cells have even demonstrated their potential to reverse aspects of aging.
This Special Issue, entitled “Genetic and Genomic Approaches to Human Aging”, seeks to collect novel studies targeting the genetic and genomic components of human aging. The scope of this Special Issue includes, but is not limited to, the following topics:
- Identification of novel age-related genes, mutations, gene expression patterns, and gene interactions in humans.
- Sequencing of age-related human genomes, epigenomes, transcriptomes, and other next-generation sequencing datasets.
- Reprogramming of aged human cells.
- Translation of age-related genetic studies and therapies from animal models.
Dr. Jeremy A. Whitson
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Genes is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- human aging
- next-generation sequencing (NGS)
- telomeres
- mutations
- genomic instability
- epigenome
- genome-wide association studies (GWAS)
- gene editing
- cellular reprogramming
- age reversal
- anti-aging
- translation
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue polices can be found here.
