Fate of Antimicrobial Resistance Genes in the Environment
A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Microbial Genetics and Genomics".
Deadline for manuscript submissions: closed (20 December 2022) | Viewed by 315
Special Issue Editor
Interests: antibiotic-resistant bacteria; antimicrobial resistance; resistance genes; molecular epidemiology; whole genome sequencing; metagenome sequencing; molecular mechanisms; horizontal transmission; phage therapy
Special Issue Information
Dear Colleagues,
Antimicrobial resistance (AMR) has emerged in humans, animals and the environment as a serious global concern. The environment is increasingly being recognized as an AMR reservoir and plays a key role in the dissemination of antimicrobial resistance genes (ARGs). The misuse or abuse of antimicrobial agents generates unnatural selective pressure in clinical and natural environments. Furthermore, the non-antimicrobial compounds (metals and biocides) prevalent in environmental samples are also responsible for the selection of resistance. ARGs are usually located on mobile genetic elements (MGEs) such as plasmids, transposons and integrons and can migrate between MGEs through horizontal gene transfer (HGT). Meanwhile, the ubiquitous presence of antibiotics, biocides and heavy metals in the environment are considered important driving forces of ARGs transmission. To better understand the dynamics of ARGs in the environment and their threat to human health, studies about the fate of ARGs in the environment are urgently needed. Potential topics for this Special Issue include, but not are limited to, the following:
- Investigations of ARGs in the environment based on metagenomics technologies;
- Genetic elements that mediate the horizontal transmission of ARGs;
- Factors governing ARG removal or transfer in the environment;
- Human health impacts and risk assessment associated with environmental ARGs;
- Strategies or technologies for the removal of ARGS from diverse sources in the environment.
Prof. Dr. An-Yun Zhang
Guest Editor
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Keywords
- antimicrobial resistance genes
- environment
- horizontal gene transfer
- fate of ARGs
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