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Genes publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Genetic and Genomic Basis of Agronomical, Quality and Functional Traits in Plants

edited by

Limin Zhang

submission deadline 15 Oct 2026 | Viewed by 147 | Submission Open

Keywords: agronomic traits; quality traits; functional genomics; quantitative trait loci (QTL); genome-wide association study (GWAS); gene editing; crop improvement; molecular breeding; transcriptomics; plant development

(This special issue belongs to the Section Plant Genetics and Genomics)

Molecular Epidemiology, Genomics and Drug Resistance Mechanisms of Pathogenic Bacteria

edited by Ming Jiang

submission deadline 15 Oct 2026 | Viewed by 138 | Submission Open

Keywords: molecular epidemiology; antimicrobial resistance; pathogenic bacteria; drug resistance mechanisms; bacterial evolution; multi-omics integration; metabolomics; antibiotic tolerance and persistence

(This special issue belongs to the Section Microbial Genetics and Genomics)

Research on Genomics and Genetics of Parasites

edited by

Kapila Gunasekera

and

Xinzhuan Su

submission deadline 15 Oct 2026 | Viewed by 120 | Submission Open

Keywords: comparative genomics; host– parasite interactions; drug resistance mechanisms; functional genomics (CRISPR-Cas9); transcriptomics and proteomics; population genetics; molecular epidemiology; vaccine target discovery; machine learning in parasitology; molecular diagnostics

(This special issue belongs to the Section Microbial Genetics and Genomics)

Unraveling the Genetic Landscape of Colorectal Cancer: The Latest Breakthroughs and Insights

edited by Nadia Saoudi Gonzalez

submission deadline 20 Oct 2026 | 3 articles | Viewed by 2625 | Submission Open

Keywords: personalized medicine; target therapy; metastatic colorectal cancer; precision oncology; biomarker discovery

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Genetic and Molecular Mechanisms in Animal Reproduction

edited by

Xianfeng Yu

submission deadline 20 Oct 2026 | Viewed by 411 | Submission Open

Keywords: gamete; embryo; gene regulation; epigenetics; cloning; IVP; ET

(This special issue belongs to the Section Animal Genetics and Genomics)

Molecular Genetics and Breeding in Pigs

edited by

Linyuan Shen

submission deadline 20 Oct 2026 | Viewed by 187 | Submission Open

Keywords: pig genetics; molecular breeding; genotype-by-environment interaction; genomic selection; gene editing; intelligent phenotyping; sustainable livestock production

(This special issue belongs to the Section Animal Genetics and Genomics)

Genetic Epidemiology and Gene-Environment Interactions

edited by Fen Yang

submission deadline 20 Oct 2026 | Viewed by 153 | Submission Open

Keywords: genetic epidemiology; gene– environment interaction; polygenic risk scores; exposome; genome-wide association studies; whole-genome sequencing; multi-omics integration; mendelian randomization; causal inference; population diversity; translational genetics; artificial intelligence in genomics

(This special issue belongs to the Section Genes & Environments)

Genetic Insights into Species Evolution: From Phylogeny to Adaptation

edited by Wei Zhang

submission deadline 20 Oct 2026 | Viewed by 146 | Submission Open

Keywords: phylogeny; phylogenomics; adaptive traits; population genomics; species diversity; economic species; marine biology; organellar genome; nuclear genome

(This special issue belongs to the Section Population and Evolutionary Genetics and Genomics)

3D Chromatin Architecture: From Computational Algorithms to Biological Functions

edited by

Minji Kim

submission deadline 20 Oct 2026 | Viewed by 121 | Submission Open

Keywords: 3D genomics; computational algorithm; genome organization; gene regulation; molecular mechanism; functional elements

(This special issue belongs to the Section Bioinformatics)

Genetic Diagnosis and Therapeutics of Eye Diseases

edited by

Suzana Konjevoda

and

Snježana Kaštelan

submission deadline 25 Oct 2026 | 4 articles | Viewed by 4302 | Submission Open

Keywords: genetic eye diseases; inherited retinal disorders; ophthalmic genetics; gene therapy; genetic diagnosis; retinitis pigmentosa; leber congenital amaurosis; personalised medicine; ocular therapeutics; genomic medicine; molecular diagnostics; precision ophthalmology

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Pharmacogenomics and Pharmacoepigenomics in Autoimmune Diseases: How Close We Are to Personalised Medicine

edited by

Yiannis Vasilopoulos

and

Ioannis S. Vizirianakis

submission deadline 25 Oct 2026 | 2 articles | Viewed by 1691 | Submission Open

Keywords: pharmacogenomics; pharmacoepigenomics; drug efficacy; drug toxicity; molecular pharmacology; autoimmune diseases

(This special issue belongs to the Section Pharmacogenetics)

Genetic Mechanisms of Synaptic Plasticity in Neuropsychiatric Disorders

edited by Lace Riggs

submission deadline 25 Oct 2026 | 1 articles | Viewed by 722 | Submission Open

Keywords: synaptic plasticity; neuropsychiatric disorders; autism spectrum disorder; schizophrenia; depression; epigenetic regulation; synaptic signaling; circuit dysfunction; gene– circuit interactions; molecular neuroscience; translational neurogenetics; epigenetics

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Recent Progress in Forensic Genetics and Molecular Identification

edited by

Maria Saiz

submission deadline 25 Oct 2026 | 1 articles | Viewed by 576 | Submission Open

Keywords: forensic genetics; molecular identification; next generation sequencing; trace DNA analysis; challenging samples

(This special issue belongs to the Section Molecular Genetics and Genomics)

Genes, Genomes, and Systems Biology in Agriculture

edited by Nick Hudson and

Pâmela A. Alexandre

submission deadline 25 Oct 2026 | 1 articles | Viewed by 541 | Submission Open

Keywords: systems biology; modelling; omics technologies; big data; machine learning; genetics; genomics; transcriptomics; microbiome; metabolomics

(This special issue belongs to the Section Technologies and Resources for Genetics)

Genetic and Genomic Analysis of Inflammatory Bowel Disease

edited by Mario Gorenjak and

Gregor Jezernik

submission deadline 25 Oct 2026 | Viewed by 418 | Submission Open

Keywords: inflammatory bowel disease; crohn’ s disease; ulcerative colitis; genomics; transcriptomics; biologicals; small-molecule drugs

(This special issue belongs to the Section Molecular Genetics and Genomics)

Genetic Mechanisms and Functional Insights in Microbiome Research

edited by

Tsute Chen

submission deadline 25 Oct 2026 | Viewed by 400 | Submission Open

Keywords: microbiome; marker genes; genomics; meta-genomics; meta-transcriptomics; proteomics; meta-proteomics; metabolomics; functional microbiome; microbiome-host interaction; microbiome-environment interaction; genetic mechanism

(This special issue belongs to the Section Microbial Genetics and Genomics)

Plant Stress Tolerance: Genetic and Genomic Mechanisms and Expression Regulation

edited by Chao Ma

submission deadline 25 Oct 2026 | 1 articles | Viewed by 257 | Submission Open

Keywords: plant stress tolerance; gene expression regulation; epigenetics; functional genomics; non-coding RNA; abiotic and biotic stress; multi-omics integration; transcriptional regulation; signal transduction; secondary metabolism

(This special issue belongs to the Section Plant Genetics and Genomics)

Genetic and Genomic Insights in Kidney Diseases: Mechanisms, Diagnosis and Therapeutics

edited by Maria Amicone and

Ersilia Nigro

submission deadline 25 Oct 2026 | Viewed by 212 | Submission Open

Keywords: cystic kidney disease; ADPKD; kidney stones; nephronophtisis; ADTKD; cystinuria; primary hyperoxaluria; NGS; MLPA; CGH array

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Tropical Plant Genetics and Breeding

edited by Jiaming Zhang

submission deadline 25 Oct 2026 | Viewed by 168 | Submission Open

Keywords: tropical crops; genomic selection; abiotic stress tolerance; disease resistance; CRISPR/Cas9; genome-wide association study (GWAS); molecular markers

(This special issue belongs to the Section Plant Genetics and Genomics)

Genetic Diagnosis and Treatment of Rare Diseases

edited by

Miao Sun

submission deadline 25 Oct 2026 | Viewed by 91 | Submission Open

Keywords: rare genetic diseases; clinical genomics; next-generation sequencing (NGS); exome and whole-genome sequencing; mitochondrial DNA (mtDNA) disorders; epigenetics and DNA methylation; RNA modification and transcriptomics; gene expression profiling; genotype– phenotype correlation; disease mechanisms; functional genomics; bioinformatics and variant interpretation; molecular diagnosis; precision medicine; gene- and RNA-based therapies

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Genetic Insights into Diseases Related to Mitochondrial Dysfunction: From Diagnosis to Treatment

edited by Luigi Citrigno and Annamaria Cerantonio

submission deadline 5 Nov 2026 | Viewed by 484 | Submission Open

Keywords: mitochondrial dysfunction; mtDNA mutations; genetic diagnosis; next-generation sequencing; neurodegeneration; metabolic disorders; mitochondrial therapeutics

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Genomic Landscapes and Precision Therapeutics of Central Nervous System Malignancies

edited by

Richard J. Tancredi

submission deadline 5 Nov 2026 | Viewed by 208 | Submission Open

Keywords: CNS malignancies; genomic profiling; precision therapeutics; tumor microenvironment; biomarker discovery

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Emerging Insights in Single-Cell and Spatial Omics for Disease Mechanisms

edited by

Yang Liu

submission deadline 5 Nov 2026 | Viewed by 167 | Submission Open

Keywords: single-cell omics; spatial omics; disease mechanisms; tissue microenvironment; cell– cell communication; multi-omics integration; cellular heterogeneity; systems biology; computational biology; precision medicine

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Genetics of Neuromuscular Disorders: From Gene Diagnosis to Treatment

edited by

Marie-Claude Sincennes

submission deadline 5 Nov 2026 | Viewed by 158 | Submission Open

Keywords: neuromuscular disorders; muscular dystrophy; myopathies; myogenesis; muscle physiology; genetics; gene therapy; functional genomics

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Advancing Crop Quality with Genomics, Genetics and Biotechnology

edited by

Xiquan Gao

and

José Á. Mercado Carmona

submission deadline 10 Nov 2026 | 2 articles | Viewed by 1137 | Submission Open

Keywords: crop quality; high throughput phenotyping; genome editing; genomic selection; nutritional quality; postharvest traits; precision breeding

(This special issue belongs to the Section Plant Genetics and Genomics)

Fetal Genetic Disorders: Prenatal Genomics for Diagnosis and Clinical Management

edited by

Katia Margiotti

submission deadline 10 Nov 2026 | Viewed by 347 | Submission Open

Keywords: prenatal diagnosis; genomic testing; NGS analysis; variant classification; pathogenic variants; precision medicine; fetal genetics; clinical utility

(This special issue belongs to the Section Genetic Diagnosis)

Human Evolution, Paleopathology, and Genetics

edited by Mauro Rubini

submission deadline 10 Nov 2026 | Viewed by 191 | Submission Open

Keywords: human evolution; paleogenomics; morphological analysis; paleopathology; (A) infectious diseases; (B) parassitosis; (C) genetic disorders; (D) neoplastic diseases; (E) nutritional deficiencies; human population

(This special issue belongs to the Section Population and Evolutionary Genetics and Genomics)

The Genetics of Prostate Cancer: From Susceptibility to Clinical Outcomes

edited by

Ludovica Pepe

submission deadline 10 Nov 2026 | Viewed by 86 | Submission Open

Keywords: prostate cancer; genetics; genomics; hereditary susceptibility; germline variants; somatic alterations; DNA damage repair; biomarkers; liquid biopsy; precision oncology

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Epigenetic Insights into Stress-Related Disorders

edited by Lei Cao

submission deadline 15 Nov 2026 | 1 articles | Viewed by 1286 | Submission Open

Keywords: stress; epigenetics; stress-related disorders; intervention; resilience

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

The Origin and Evolution of Genetic Code

edited by

Kenji Ikehara

submission deadline 15 Nov 2026 | 2 articles | Viewed by 1220 | Submission Open

Keywords: origin of the genetic code; evolution of the genetic code; origin of gene; evolution of gene; origin of protein; evolution of protein; origin of life; evolution of life

(This special issue belongs to the Section Molecular Genetics and Genomics)

Genetic Insights into Pediatric Neurological Disorders: From Mechanisms to Therapies

edited by Ji Yoon Han

submission deadline 15 Nov 2026 | 1 articles | Viewed by 944 | Submission Open

Keywords: pediatric neurological disorders; neurogenetics; multi-omics integration; precision medicine; brain organoid models

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Genetic Mouse Models of Human Disease

edited by Jiale Wang

submission deadline 15 Nov 2026 | Viewed by 569 | Submission Open

Keywords: mouse models; human disease; genetic disorders; genome editing; CRISPR; inflammation; cancer biology; disease mechanisms; preclinical models; translational research

(This special issue belongs to the Section Molecular Genetics and Genomics)

Genetic Profiling and Molecular Analysis in Autism Spectrum Disorders

edited by John Jay Gargus

submission deadline 15 Nov 2026 | Viewed by 438 | Submission Open

Keywords: whole-exome and genome sequencing in ASD; functional genomics of high-confidence ASD risk genes; transcriptomics and splicing variants in the autistic brain; calcium signaling and ion channelopathies; chromatin and epigenetic dysregulation in ASD; mitochondrial dysfunction and oxidative stress; immune– neural signaling cross-talk; systemic extracerebral traits associated with ASD; stratification of ASD subtypes; sex-biased molecular mechanisms in ASD; integrative omics for therapeutic target discovery

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Linking Phenotypic and Molecular Evolution: Mechanisms and Models

edited by Wen Wei

submission deadline 15 Nov 2026 | Viewed by 427 | Submission Open

Keywords: genomic and phenotypic evolution; adaptive evolution; selection and genetic drift; genotype– phenotype– fitness landscape; accumulation of mutations; evolvability of complex traits; molecular evolution drivers; transcriptomic agaianst protein-coding evolution; experimental evolution

(This special issue belongs to the Section Population and Evolutionary Genetics and Genomics)

Genetic Studies of Cancer Therapy

edited by Nikos G. Gavalas

submission deadline 15 Nov 2026 | Viewed by 262 | Submission Open

Keywords: genetics; cancer; oncology; genetic variations; response; treatment; epigenetics; genomics; biomarkers; modifications

(This special issue belongs to the Section Molecular Genetics and Genomics)

Chromatin and DNA Transcription, Replication, Repair and Recombination

edited by Adam Yongxin Ye

submission deadline 15 Nov 2026 | Viewed by 250 | Submission Open

Keywords: chromatin structure; 3D genome organization; loop extrusion; DNA transcription; DNA replication; DNA repair; DNA recombination

(This special issue belongs to the Section Molecular Genetics and Genomics)

Genetic Analysis of the Microbiome and Its Role in Animal Health

edited by Xiang Li

submission deadline 15 Nov 2026 | Viewed by 64 | Submission Open

Keywords: precision animal health; microbiome and metagenomics; zoonotic pathogens; food safety; precision intervention; comparative genomics; molecular genetics

(This special issue belongs to the Section Animal Genetics and Genomics)

NGS Applications in Hereditary Kidney Diseases: From Diagnostics to Clinical Impact

edited by Ighli Di Bari

submission deadline 15 Nov 2026 | Viewed by 51 | Submission Open

Keywords: ADPKD; NGS; nephrogenetics; WES; renal pharmacogenetics

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Harnessing Multi-Omics Approaches to Unravel Plant–Microbe Interactions in Cultivated Plants: Implications for Climate Resilience and Sustainable Agriculture

edited by Samathmika Ravi,

Maria Cristina Della Lucia

and

Piergiorgio Stevanato

submission deadline 20 Nov 2026 | 1 articles | Viewed by 2296 | Submission Open

Keywords: multi-omics; plant– microbe interactions; climate resilience; agricultural sustainability; microbial dynamics

(This special issue belongs to the Section Plant Genetics and Genomics)

Integrative Cancer Genomics: Unveiling Novel Biomarkers

edited by

Victor Jin

and

Shengtong Han

submission deadline 20 Nov 2026 | Viewed by 431 | Submission Open

Keywords: cancer; integrative genomics; cancer biomarker; multi-omics; cancer genomics

(This special issue belongs to the Section Molecular Genetics and Genomics)

Molecular Genetics and Genomics of Plant Light Regulation

edited by

Bo Zhou

submission deadline 20 Nov 2026 | Viewed by 147 | Submission Open

Keywords: light signal transduction; plant development; molecular genetics; genomics; photoreceptor; flowering regulation; fruit ripening; anthocyanin synthesis; multi-omics; crop breeding

(This special issue belongs to the Section Plant Genetics and Genomics)

Advances in Plant Evolutionary Genomics

edited by

Hui Wang

submission deadline 20 Nov 2026 | Viewed by 127 | Submission Open

Keywords: plant evolution; comparative genomics; phylogenomics; adaptation; population genomics; genome evolution; natural selection; genetic diversity; phenotypic variation; molecular evolution; environmental adaptation

(This special issue belongs to the Section Plant Genetics and Genomics)

Genetic Dissection and Molecular Mechanisms of Plant Metabolic Pathways

edited by

Fei Zhou

submission deadline 20 Nov 2026 | Viewed by 56 | Submission Open

Keywords: plant metabolism; specialized metabolism; multi-omics integration; functional genomics; metabolic pathway; transcriptional regulation; plant biochemistry; metabolic engineering

(This special issue belongs to the Section Plant Genetics and Genomics)

Perspectives on Craniofacial Genomics, Genetics, and Development

edited by Michael Cunningham

submission deadline 20 Nov 2026 | Viewed by 51 | Submission Open

Keywords: craniofacial; genetics; development; patterning; evolution; malformation; animal model; sense organs; cranial nerves; cervical spine

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Novel Strategies in Forensic Genetics

edited by

Marie Allen

submission deadline 25 Nov 2026 | 5 articles | Viewed by 2835 | Submission Open

Keywords: foresic DNA analysis; sample collection; DNA extraction; novel DNA markers; MPS; bioinformatics

(This special issue belongs to the Section Technologies and Resources for Genetics)

Genetic and Molecular Mechanisms of Insect Resistance

edited by Fen Li and Shuqian Tan

submission deadline 25 Nov 2026 | Viewed by 388 | Submission Open

Keywords: insect resistance; molecular mechanisms; genetic basis; detoxification enzymes; cytochrome P450; target-site resistance; metabolic resistance; gene amplification; gene expression regulation; genomics; transcriptomics; gene editing; adaptive evolution; insecticide resistance management (IRM); pest management

(This special issue belongs to the Section Animal Genetics and Genomics)

Molecular Genetics and Genomic Medicine in Rare Disease

edited by Gu-Hwan Kim

submission deadline 25 Nov 2026 | Viewed by 324 | Submission Open

Keywords: rare genetic diseases; inherited disorders; genetic testing; next-generation sequencing; variant interpretation; genotype– phenotype correlation; functional genomics; molecular diagnosis

(This special issue belongs to the Section Molecular Genetics and Genomics)

Functional Genomics and Genetics in Insects

edited by

Ji-Feng Shi

submission deadline 25 Nov 2026 | Viewed by 159 | Submission Open

Keywords: insect functional genomics; insect genetics; RNA interference; CRISPR/Cas9; transcriptomics; cuticle biology; chitin metabolism; gene regulation; pest insects; molecular mechanisms

(This special issue belongs to the Section Animal Genetics and Genomics)

Genetic and Epigenetic Insights in Autoimmune Diseases

edited by

Cinzia Ciccacci

and Andrea Latini

submission deadline 30 Nov 2026 | 1 articles | Viewed by 1259 | Submission Open

Keywords: autoimmune disorders; genetic factors; epigenetic factors; polymorphisms; gene– gene interactions; gene– miRNA interactions; miRNA; methylation state; genetic susceptibility

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Forensic DNA Profiling: PCR Techniques and Innovations

edited by

António Amorim

and

Laura Mendes Cainé

submission deadline 5 Dec 2026 | 3 articles | Viewed by 4387 | Submission Open

Keywords: forensic DNA profiling; PCR-based forensics; DNA analysis; next-generation sequencing; short tandem repeat (STR); Y-STR; single-nucleotide polymorphisms (SNPs); Y-SNP

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

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