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Genes publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Advances in Prenatal and Postnatal Genetic Testing: Precision Diagnosis for Genetic Disorders

edited by

Spiros Vittas

and Eirini Louizou

submission deadline 20 Sep 2026 | 1 articles | Viewed by 1249 | Submission Open

Keywords: genetic testing; prenatal diagnosis; postnatal diagnosis; precision medicine

(This special issue belongs to the Section Genetic Diagnosis)

New Insight into the Genetic and Molecular Aspects of Yeast Nutrient Metabolism

edited by Roman Maslanka and

Renata Zadrag-Tecza

submission deadline 20 Sep 2026 | Viewed by 508 | Submission Open

Keywords: yeasts as a model organism; yeast metabolism; nutrient sensing; sugar/hexose transport; central carbon metabolism; catabolite repression; nutrient availability; resource allocation; calorie restriction; cAMP-PKA signaling; metabolic flux; metabolic adaptation; genetic and transcriptional regulation; cellular homeostasis; molecular biology of yeast

(This special issue belongs to the Section Molecular Genetics and Genomics)

Wheat Genomic Study

edited by

Xiaoyan Li

submission deadline 20 Sep 2026 | Viewed by 164 | Submission Open

Keywords: Triticum aestivum; pangenome; QTL mapping; GWAS; stress tolerance; yield; genomic selection; breeding

(This special issue belongs to the Section Plant Genetics and Genomics)

Clinical Research Advances in Pharmacogenetics and Pharmacogenomics

edited by Martina Hahn

submission deadline 20 Sep 2026 | Viewed by 142 | Submission Open

Keywords: pharmacogenetics; pharmacogenomics; personalized medicine; gender medicine; genetic testing; drug response; therapeutic outcomes; adverse drug reactions; clinical research; genetic markers; precision therapeutics

(This special issue belongs to the Section Pharmacogenetics)

Mechanisms and Therapeutics in Autism: From Genes to Clinical Practice

edited by Iliyana Pacheva

submission deadline 20 Sep 2026 | Viewed by 121 | Submission Open

Keywords: autism; autistic spectrum disorder; epilepsy and autism; pathogenesis; mitochondrial dysfunction; inflammation; genes and autism; comorbidities; biomarkers; precise medicine; treatment

(This special issue belongs to the Section Neurogenomics)

Horticultural Functional Genomics and Breeding

edited by

Hanqiang Liu

submission deadline 20 Sep 2026 | Viewed by 73 | Submission Open

Keywords: functional genomics; multi-omics integration; epigenetic regulation; gene regulatory networks; forward genetics; GWAS; genome engineering; molecular breeding; precision breeding; trait dissection

(This special issue belongs to the Section Plant Genetics and Genomics)

Hereditary Traits and Diseases in Companion Animals

edited by

Lucie Chevallier

and

Marie Abitbol

submission deadline 25 Sep 2026 | 5 articles | Viewed by 6474 | Submission Open

Keywords: genetic traits; hereditary diseases; companion animals; spontaneous disease models; veterinary genetics; genetic selection; breed-specific diseases

(This special issue belongs to the Section Animal Genetics and Genomics)

Physiological and Molecular Mechanisms of Plant Stress Response

edited by

Yakupjan Haxim

submission deadline 25 Sep 2026 | 4 articles | Viewed by 4133 | Submission Open

Keywords: drought stress; heat stress; cold stress; salinity stress; pathogen infection; multi-omic approaches; gene expression; plant resistance

(This special issue belongs to the Section Plant Genetics and Genomics)

Epigenetic Regulation in Tumors

edited by

Anca Botezatu

submission deadline 25 Sep 2026 | 2 articles | Viewed by 1941 | Submission Open

Keywords: cancer epigenetics; epigenetic mechanisms; tumor microenvironment; epigenetic biomarkers; multi-omics and bioinformatics

(This special issue belongs to the Section Epigenomics)

The Genetic Lens: A New Era in Ophthalmology

edited by

Stefania Zampatti

and

Emiliano Giardina

submission deadline 25 Sep 2026 | 3 articles | Viewed by 1425 | Submission Open

Keywords: ophthalmology; genomics; artificial intelligence; inherited retinal disease; blindness

(This special issue belongs to the Section Genetic Diagnosis)

Livestock Germplasm Resources, Genetics, and Breeding

edited by

Enrico D’ Alessandro

and Marco Tolone

submission deadline 25 Sep 2026 | Viewed by 657 | Submission Open

Keywords: animal genetics; genomics; animal production; metagenomics; genome-wide association study (GWAS); product quality; fertility; health; coat color; molecular traceability; biodiversity

(This special issue belongs to the Section Animal Genetics and Genomics)

Genetic Mechanisms of Obesity

edited by

Thangiah Geetha

submission deadline 25 Sep 2026 | Viewed by 330 | Submission Open

Keywords: obesity; genetic mechanisms; epigenetics; DNA methylation; genome-wide association studies; multi-omics; transcriptomics; foundtional genomics; gene– environment interactions; childhood obesity; energy metabolism; precision medicine; gut microbiota

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Gene-Regulated Signaling Pathways in Cancer

edited by Alexander Damalas

submission deadline 25 Sep 2026 | Viewed by 276 | Submission Open

Keywords: caveolin-1 (CAV1); caveolae; Ras; EMT; invasion; MAPK; PI3K-Akt; membrane curvature (MC)

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Epigenetic Control of Animal Reproduction and Key Traits

edited by

Enqi Liu

submission deadline 25 Sep 2026 | Viewed by 270 | Submission Open

Keywords: animal reproduction; epigenetics; spermatogenesis; oogenesis; heterosis; transgenerational inheritance; early embryonic development; DNA methylation; histone modification; non-coding RNA; chromatin remodeling; genomic imprinting; molecular breeding; genomic imprinting; economic traits

(This special issue belongs to the Section Animal Genetics and Genomics)

Cytogenetics and Cytogenomics in Clinical Diagnostics: Innovations and Applications—2nd Edition

edited by

Jinglan Liu

submission deadline 25 Sep 2026 | Viewed by 203 | Submission Open

Keywords: karyotyping; cytogenomics; chromosome territory (CT); nuclear architecture; clinical oncology; germline; development; neuropsychiatric; artificial intelligence (AI)

(This special issue belongs to the Section Cytogenomics)

Epigenetic Regulation of Germline Cells: From Meiosis to Epigenetic Inheritance

edited by Elena De la Casa-Esperon

submission deadline 25 Sep 2026 | Viewed by 194 | Submission Open

Keywords: epigenetic regulation; germline cells; meiosis; meiotic recombination; chromosome segregation; environmental effects on germline; 3D genome organization; transgenerational epigenetic inheritance

(This special issue belongs to the Section Epigenomics)

Genomic Mutations and Susceptibility in Breast Cancer

edited by Balaji Virassamy

submission deadline 25 Sep 2026 | Viewed by 154 | Submission Open

Keywords: genetic variants; somatic mutation landscape; morphological variation; oncogenic timing; next-generation sequencing; targeted therapies

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Genetic and Epigenetic Drivers of Lung Cancer Heterogeneity and Therapy Resistance

edited by Maria Palmieri and Viola Bianca Serio

submission deadline 25 Sep 2026 | Viewed by 134 | Submission Open

Keywords: non-small cell lung cancer (NSCLC); intratumor heterogeneity; acquired resistance; DNA methylation; histone modifications; non-coding RNAs (ncRNAs); epithelial– mesenchymal transition (EMT); single-cell sequencing; liquid biopsy; targeted therapy

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Genomic Responses to Rapid Environmental Change in Biodiversity Hotspots

edited by Diana Daniela Moreno-Santillan and Diana Aguilar Gomez

submission deadline 25 Sep 2026 | Viewed by 133 | Submission Open

Keywords: population genetics; phylogenetics; adaptation; environmental change; conservation genetics

(This special issue belongs to the Section Population and Evolutionary Genetics and Genomics)

Genetics, Breeding and Genomic Improvement of Aquaculture Fish

edited by Tianqing Huang

submission deadline 25 Sep 2026 | Viewed by 91 | Submission Open

Keywords: aquaculture; fish breeding; genetics; polyploidy; molecular biology; gonadal development

(This special issue belongs to the Section Animal Genetics and Genomics)

Corn Breeding for Disease Resistance

edited by Xuanjun Feng

submission deadline 25 Sep 2026 | Viewed by 76 | Submission Open

Keywords: maize; disease resistance; corn breeding; resistance gene; QTL mapping; genomic-assisted breeding; gene functional analysis; plant– pathogen interaction; genetic diversity; molecular genetics; crop genetic improvement; cereal crop

(This special issue belongs to the Section Plant Genetics and Genomics)

Genetic Aspects of Autoimmune Diseases

edited by Cheuk Wun Li

submission deadline 10 Oct 2026 | 5 articles | Viewed by 3074 | Submission Open

Keywords: autoimmune diseases; genetics; genetic variants; polygenic; therapies

(This special issue belongs to the Section Molecular Genetics and Genomics)

Identifying Fertility Biomarkers Using Omics Approach

edited by

Muhammet Rasit Ugur

submission deadline 10 Oct 2026 | 1 articles | Viewed by 803 | Submission Open

Keywords: fertility; infertility; biomarker; omics; multi-omics; genomics; transcriptomics; proteomics; metabolomics; epigenomics; lipidomic; microbiomics

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Sperm DNA Changes: Causes, Diagnostics, and Implications for Fertility and Offspring Health

edited by

Jonatan Axelsson

and

Humaira Gowher

submission deadline 10 Oct 2026 | 1 articles | Viewed by 697 | Submission Open

Keywords: sperm DNA; sperm DNA fragmentation; germ cell mutations; de novo mutations; offspring effects; infertility; sperm chromatin structure; epigenetics; lifestyle; environmental effects; error-corrected sequencing; aneuploidy; chromosome aberrations; pregnancy; child

(This special issue belongs to the Section Genetic Diagnosis)

Abiotic Stress in Crop: Molecular Genetics and Genomics

edited by Xuke Lu

submission deadline 10 Oct 2026 | 1 articles | Viewed by 487 | Submission Open

Keywords: plants; abiotic stresses; molecular mechanism; differentially expressed genes (DEGs); regulatory network

(This special issue belongs to the Section Plant Genetics and Genomics)

Genome Sequencing and Genetic Testing for Cancer

edited by

Kapila Gunasekera

submission deadline 10 Oct 2026 | Viewed by 214 | Submission Open

Keywords: next-generation sequencing (NGS); precision oncology; liquid biopsy and ctDNA; whole-genome sequencing (WGS); cancer susceptibility genes; somatic mutation profiling; pharmacogenomics; machine learning and AI in omics; multi-omics integration; biomarker discovery; targeted therapy; molecular diagnostics

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Utilizing Animal Disease Models to Understand Human Genetics

edited by

Tiziana Orsini

submission deadline 10 Oct 2026 | Viewed by 162 | Submission Open

Keywords: animal models of human disease; genotype-phenotype correlation; functional genomics; developmental biology; translational genetics; variant validation; precision medicine

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Cancer Driver Mutations and Tumor Evolution

edited by Yusi Fu

submission deadline 10 Oct 2026 | Viewed by 66 | Submission Open

Keywords: driver mutations; tumor evolution; clonal dynamics; intratumor heterogeneity; somatic mosaicism; single-cell genomics; mutational signatures; clonal hematopoiesis; tumor microenvironment

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Genetic and Morphological Diversity in Plants

edited by

P. Roxanne Kellar

submission deadline 15 Oct 2026 | 6 articles | Viewed by 5098 | Submission Open

Keywords: biodiversity; conservation; genetic structure; genetics; genotype; germplasm; haplotype; high-throughput sequencing; invasive species; microsatellites; molecular markers; morphological characters; morphology; morphometrics; morphotype; next-generation sequencing; phenotype; systematics; taxonomy; variation

(This special issue belongs to the Section Plant Genetics and Genomics)

Genetic and Epigenetic Factors for Autoimmune Diseases

edited by

Ulises De La Cruz-Mosso

submission deadline 15 Oct 2026 | 2 articles | Viewed by 3439 | Submission Open

Keywords: single nucleotide variants; polymorphism; mutations; microRNAs; HLA genes; cytokine gene; DNA methylation; rheumatoid arthritis; systemic lupus erythematosus; exposome

(This special issue belongs to the Section Epigenomics)

Diagnosis, Management and Therapy of Rare Diseases

edited by Giorgia Girotto

submission deadline 15 Oct 2026 | 3 articles | Viewed by 2101 | Submission Open

Keywords: rare and ultrarare genetic diseases; genetic mechanisms; gene-tailored management; personalized therapeutic approaches

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Advances in Human Reproductive and Prenatal Genetics

edited by Edith Said

submission deadline 15 Oct 2026 | 1 articles | Viewed by 1614 | Submission Open

Keywords: reproductive genetics; female infertility; male infertility; recurrent pregnancy loss; preconception genetic testing; pre-implantation genetic testing; prenatal genetics; non-invasive prenatal testing; molecular genetics; cytogenetics; molecular cytogenetics

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

The Function and Molecular Mechanism for Immune Responses in Human Diseases

edited by Zsofia Banlaki

submission deadline 15 Oct 2026 | 2 articles | Viewed by 1425 | Submission Open

Keywords: leukocyte; cytokine; immune receptor; signal transduction; gene expression; antibody-antigen; major histocompatibility complex; complement system; inflammation

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Aquatic Germplasm Resources and Genetic Breeding

edited by Wei Song

submission deadline 15 Oct 2026 | 1 articles | Viewed by 695 | Submission Open

Keywords: fish; shrimp; shellfish; algae; geographical population; morphological difference; cytochrome oxidase subunit I (COI); microsatellites; genetic structure; genetic diversity; gene cloning; cellular localization; RNAi; gene overexpression

(This special issue belongs to the Section Animal Genetics and Genomics)

Chromatin Modifications and RNA-Based Regulation of Gene Expression

edited by Alonso Javier Pardal

submission deadline 15 Oct 2026 | 1 articles | Viewed by 566 | Submission Open

Keywords: chromatin modifications; RNA; gene expression; transcription; chromatin boundaries; RNA-binding proteins

(This special issue belongs to the Section Molecular Genetics and Genomics)

From Genes to Systems: Genetic and Epigenetic Control of the Metastatic Cascade

edited by

Eric Rahrmann

submission deadline 15 Oct 2026 | Viewed by 326 | Submission Open

Keywords: cancer metastasis; genetic alterations; epigenetic reprogramming; tumor heterogeneity; lineage plasticity; metastatic niche formation; dormancy; circulating tumor cells (CTCs); immune evasion; therapy resistance; tumor microenvironment

(This special issue belongs to the Section Epigenomics)

Genomics for Smart and Greener Agriculture

edited by Loan Nguyen and Christie Warburton

submission deadline 15 Oct 2026 | Viewed by 240 | Submission Open

Keywords: genomics; transcriptomics; metagenomics; microbiome; gene editing

(This special issue belongs to the Section Molecular Genetics and Genomics)

Molecular Mechanisms and Applications of Forensic Genetics

edited by Sara C Zapico

submission deadline 15 Oct 2026 | Viewed by 196 | Submission Open

Keywords: forensic biology ; forensic genetic genealogy; next-generation sequencing (NGS); epigenetic markers/DNA methylation/non-coding RNAs; microbiome forensics; biomarker detection; DNA phenotyping; DNA degradation and preservation

(This special issue belongs to the Section Molecular Genetics and Genomics)

Gene Editing Technology for Xenotransplantation in Human Genetic Diseases

edited by Brendan J. Keating

submission deadline 15 Oct 2026 | Viewed by 135 | Submission Open

Keywords: xenotransplantation; gene editing; CRISPR/Cas; genetically modified donor animals; genome engineering; immunologic incompatibility

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Genetic and Genomic Basis of Agronomical, Quality and Functional Traits in Plants

edited by

Limin Zhang

submission deadline 15 Oct 2026 | Viewed by 110 | Submission Open

Keywords: agronomic traits; quality traits; functional genomics; quantitative trait loci (QTL); genome-wide association study (GWAS); gene editing; crop improvement; molecular breeding; transcriptomics; plant development

(This special issue belongs to the Section Plant Genetics and Genomics)

Molecular Epidemiology, Genomics and Drug Resistance Mechanisms of Pathogenic Bacteria

edited by Ming Jiang

submission deadline 15 Oct 2026 | Viewed by 109 | Submission Open

Keywords: molecular epidemiology; antimicrobial resistance; pathogenic bacteria; drug resistance mechanisms; bacterial evolution; multi-omics integration; metabolomics; antibiotic tolerance and persistence

(This special issue belongs to the Section Microbial Genetics and Genomics)

Genetic Mechanisms of Inflammation and Immune Regulation in Tumors

edited by

Fuduan Peng

submission deadline 15 Oct 2026 | Viewed by 100 | Submission Open

Keywords: bioinformatics; computational biology; tumor microenvironment; single-cell RNA sequencing; spatial omics; microbiome– immune interaction; immunotherapy targets; pan-cancer; machine learning

(This special issue belongs to the Section Molecular Genetics and Genomics)

Research on Genomics and Genetics of Parasites

edited by

Kapila Gunasekera

and

Xinzhuan Su

submission deadline 15 Oct 2026 | Viewed by 85 | Submission Open

Keywords: comparative genomics; host– parasite interactions; drug resistance mechanisms; functional genomics (CRISPR-Cas9); transcriptomics and proteomics; population genetics; molecular epidemiology; vaccine target discovery; machine learning in parasitology; molecular diagnostics

(This special issue belongs to the Section Microbial Genetics and Genomics)

Unraveling the Genetic Landscape of Colorectal Cancer: The Latest Breakthroughs and Insights

edited by Nadia Saoudi Gonzalez

submission deadline 20 Oct 2026 | 3 articles | Viewed by 1320 | Submission Open

Keywords: personalized medicine; target therapy; metastatic colorectal cancer; precision oncology; biomarker discovery

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Genetic and Molecular Mechanisms in Animal Reproduction

edited by

Xianfeng Yu

submission deadline 20 Oct 2026 | Viewed by 362 | Submission Open

Keywords: gamete; embryo; gene regulation; epigenetics; cloning; IVP; ET

(This special issue belongs to the Section Animal Genetics and Genomics)

Molecular Genetics and Breeding in Pigs

edited by

Linyuan Shen

submission deadline 20 Oct 2026 | Viewed by 139 | Submission Open

Keywords: pig genetics; molecular breeding; genotype-by-environment interaction; genomic selection; gene editing; intelligent phenotyping; sustainable livestock production

(This special issue belongs to the Section Animal Genetics and Genomics)

Genetic Insights into Species Evolution: From Phylogeny to Adaptation

edited by Wei Zhang

submission deadline 20 Oct 2026 | Viewed by 110 | Submission Open

Keywords: phylogeny; phylogenomics; adaptive traits; population genomics; species diversity; economic species; marine biology; organellar genome; nuclear genome

(This special issue belongs to the Section Population and Evolutionary Genetics and Genomics)

Genetic Epidemiology and Gene-Environment Interactions

edited by Fen Yang

submission deadline 20 Oct 2026 | Viewed by 102 | Submission Open

Keywords: genetic epidemiology; gene– environment interaction; polygenic risk scores; exposome; genome-wide association studies; whole-genome sequencing; multi-omics integration; mendelian randomization; causal inference; population diversity; translational genetics; artificial intelligence in genomics

(This special issue belongs to the Section Genes & Environments)

3D Chromatin Architecture: From Computational Algorithms to Biological Functions

edited by

Minji Kim

submission deadline 20 Oct 2026 | Viewed by 49 | Submission Open

Keywords: 3D genomics; computational algorithm; genome organization; gene regulation; molecular mechanism; functional elements

(This special issue belongs to the Section Bioinformatics)

Genetic Diagnosis and Therapeutics of Eye Diseases

edited by

Suzana Konjevoda

and

Snježana Kaštelan

submission deadline 25 Oct 2026 | 3 articles | Viewed by 3736 | Submission Open

Keywords: genetic eye diseases; inherited retinal disorders; ophthalmic genetics; gene therapy; genetic diagnosis; retinitis pigmentosa; leber congenital amaurosis; personalised medicine; ocular therapeutics; genomic medicine; molecular diagnostics; precision ophthalmology

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

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