Myocardial Oxygen Consumption and Myocardial Efficiency in Various Physiological States

A special issue of Journal of Cardiovascular Development and Disease (ISSN 2308-3425). This special issue belongs to the section "Acquired Cardiovascular Disease".

Deadline for manuscript submissions: 15 April 2025 | Viewed by 67

Special Issue Editor


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Guest Editor
1. Department of Anesthesiology, Cooper University Hospital, Camden, NJ 08103, USA
2. Cooper Medical School of Rowan University, Camden, NJ 08103, USA
Interests: cardiac mechanics; LV pressure-volume; computational modeling; MVO2; myocardial efficiency; physiological and pathophysiological settings

Special Issue Information

Dear Colleagues,

Over 60 years ago, a significant milestone was achieved with the first measurement of the heart’s myocardial oxygen consumption (MVO2) in humans. This groundbreaking event paved the way for over 30 years of extensive studies to evaluate MVO2 and its surrogate, myocardial efficiency (MyoEff), in subjects with various cardiac diseases. Since then, sporadic reports have evaluated MVO2 and MyoEff. These studies were invasive and required special catheters, limiting the ongoing pursuit of these measures. The use of left ventricular pressure-volume (PV) constructs led to the reintroduction of MyoEff in the late 1980s and early 1990s. However, conducting PV studies in patients is plagued by the same issues listed previously.

Despite these hurdles, the field of cardiac research has seen significant progress. Nuclear positron emission tomography has emerged as a non-invasive option for measuring MVO2, offering a promising alternative to invasive methods. Combining these data with a collection of stroke work (SW) data allows for the non-invasive calculation of MyoEff. In contrast, numerous studies have used indirect metrics to provide directional evaluation of MVO2 and MyoEff, in contrast to measures of SW and MVO2. The following Special Issue underscores the importance of understanding myocardial performance and the impact on MyoEff across disease states, as it can provide crucial insights and guide treatment strategies.

Dr. Lawrence J. Mulligan
Guest Editor

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Keywords

  • myocardial oxygen consumption
  • stroke work
  • myocardial efficiency
  • cardiovascular disease
  • pregnancy
  • heart failure
  • aortic valve disease

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Published Papers

This special issue is now open for submission.
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