Recent Advancements in Cardiovascular Gene Therapy and Vascular Biology

A special issue of Journal of Cardiovascular Development and Disease (ISSN 2308-3425). This special issue belongs to the section "Genetics".

Deadline for manuscript submissions: closed (15 July 2022)

Special Issue Editors


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Guest Editor
Head of the Laboratory for Vascular Biology, Department of Experimental Medicine, Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo 650002, Russia
Interests: vascular biology; atherosclerosis; endothelial dysfunction; intimal hyperplasia; vascular inflammation; vasa vasorum; calcification; calciprotein particles
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Guest Editor
1. Head of the Laboratory for Regenerative Biomedicine, Institute of Cytology, Russian Academy of Sciences, 194064 St. Petersburg, Russia
2. Group Leader, Laboratory of Molecular Cardiology, Almazov National Medical Research Centre, 197341 St. Petersburg, Russia
Interests: notch signaling; osteogenic differentiation; mesenchymal stem cells; endothelial–mesenchymal interactions

Special Issue Information

Dear Colleagues,

Current conceptual and technical advances in omics approaches (e.g., single-cell RNA sequencing (scRNA-seq), single-cell assay for transposase-accessible chromatin sequencing (scATAC-seq), and cellular indexing of transcriptomes and epitopes by sequencing (CITE-seq)), as well as constant improvements in the development of genetically modified animal models and novel modalities for gene delivery have provided a solid ground for the breakthrough discoveries transforming the vascular biology frontier. Moreover, exploratory high-throughput studies and confirmatory molecular cloning experiments demonstrate a remarkable synergy, together resulting in the development of promising therapeutic options which show an excellent translational potential. For instance, stem cell transplantation has been suggested as a potential treatment of chronic heart failure, while vascular tissue engineering was used to design small-diameter tubular scaffolds exhibiting high patency rates upon the implantation into the circulatory system of large animals. However, an impressive armamentarium of researchers is still insufficiently implemented into cardiovascular medicine. A proper integration between basic scientists, industrial manufacturers, clinicians, and policy-makers represents a major challenge for the biomedical community and requires considerable efforts to improve the outcome of patients suffering from cardiovascular disease.

This Special Issue presents technically sound, novel, and impactful findings that have been obtained by the leading research groups. Under pathological conditions, the molecular portfolio of cardiac, valvular, and vascular cell populations becomes reconfigured for adapting to the biochemical alterations and perturbed microenvironment. Here, we focus on the molecular pathways that are deregulated in heart and vessels in different cardiovascular disorders, and even in asymptomatic patients with various cardiovascular risk factors, and illustrate their importance in frequent clinical settings. Further, we provide examples of pathophysiological scenarios behind the non-canonical cardiovascular risk factors and experimental interventions to correct the respective homeostasis disturbances. As gene delivery supplies physicians with a unique option for non-invasive and targeted treatment, related papers would be given high priority. Ultimately, this collection will contribute to the dissemination of knowledge on the topic and is aimed to conceptualize our understanding of cellular phenotypes in cardiovascular disease. The Issue contains both exemplary original research studies and comprehensive review articles critically discussing the recent discoveries in the field.

Dr. Anton G. Kutikhin
Dr. Anna B. Malashicheva
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Cardiovascular Development and Disease is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cardiovascular disease
  • cardiovascular pathophysiology
  • vascular biology
  • vascular tissue engineering
  • regenerative medicine
  • cell transplantation
  • gene delivery, molecular cloning
  • viral vectors
  • genetically modified animals
  • molecular pathways
  • biochemical alterations
  • drug development targeted therapy
  • preclinical research
  • clinical trials

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Published Papers

There is no accepted submissions to this special issue at this moment.
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