Comprehensive Venom Analysis: Pioneering Research Integrating Multi-Omics Technologies
A special issue of Toxins (ISSN 2072-6651). This special issue belongs to the section "Animal Venoms".
Deadline for manuscript submissions: 28 February 2025 | Viewed by 178
Special Issue Editor
Interests: proteomics; snake venom; molecular toxinology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
According to venom databases and scientists, there are more than 200,000 venomous species worldwide. Venoms are a rich source of molecules, with a large variety of biological activities and toxicities (hemotoxic, neurotoxic, or cytotoxic), used to capture and digest their prey. These toxins, during envenomation, target multiple cellular systems affecting inflammatory responses, cellular apoptosis, perturbations in neurophysiological as well as neuromuscular action, and hemostasis, all of which will ultimately lead to the death of venomous species’ prey. Interestingly, venoms are a rich source of bioactive molecules that hold great promise for therapeutic applications. Venoms and their isolated toxins, as pharmacological sources, have enormous biomedical potential for treating heart attacks, strokes, and cancer. The global exploration of venom and understanding of the pathophysiology of venomous bites require the use of omics approaches to characterize venom, and these omics approaches offer insights into the venom proteome, although further investigation is needed as many of these venoms have not been characterized and the full medicinal scope of these toxins is still emerging. More efforts are needed to characterize venom composition across species and within the same species. To be effective, these data-gathering studies should encompass different levels of biological information, including genomics, transcriptomics, proteomics, and metabolomics. Herein, this Special Issue of Toxins is specifically focused on publishing recent research activities exploring comprehensive venom analyses and pioneering research integrating proteomics, transcriptomics, and multi-omics technologies. Toxins is an outstanding forum for venom research due to its notable reputation in snake venom and broader toxicology interests. We strongly believe that the articles published will be of great interest to evolutionary biologists studying toxins, as well as immunologists, biotechnologists, and pharmacologists working in developing next-generation therapeutics.
Dr. Jacob Galan
Guest Editor
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Keywords
- exposomics
- venomics
- proteomics
- transcriptomics
- multi-omics
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