Research on Pathogenesis and the Therapy of Chronic Kidney Disease

Dear Colleagues,

Chronic kidney disease (CKD), with progressively rising incidence and prevalence, poses a tremendous threat to health, including an increased risk of end-stage kidney disease, cardiovascular disease, anemia, and bone diseases, therefore increasing financial burdens. However, we have limited practically effective interventions for CKD currently, except for renin-angiotensin-aldosterone system (RAAS) blockades and the recent advances of the sodium-glucose cotransporter-2 (SGLT2) inhibitors treatment. The heterogenous causes of CKD consist of glomerular, tubular, peritubular capillary, and interstitial damages from toxic or metabolic substances, immunological injury, and other miscellaneous causes. Without timely and effective interventions, these damages could lead to nephrotoxic inflammation and eventual kidney fibrosis. The complex pathogenesis and the heterogenous causes of CKD make the development of therapies extremely challenging. Exploring the pathogenesis of CKD and the effectiveness of modulating the paramount pathogenesis of CKD facilitate the development of novel therapies for preventing CKD initiation and progression. This Special Issue, entitled “Research on Pathogenesis and Therapy of Chronic Kidney Disease”, focuses on the investigations of the core pathogenesis of CKD and related interventions, including in vitro study, animal study, and clinical study.

Prof. Dr. Chih‐Kang Chiang
Guest Editor

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• chronic kidney disease
• pathogenesis
• therapy
• nephrotoxins
• inflammation
• fibrosis
• hypoxia
• oxidative stress
• endoplasmic reticulum stress
• autophagy