Antibodies for Innovative Studies of Bacterial Toxins
A special issue of Toxins (ISSN 2072-6651). This special issue belongs to the section "Bacterial Toxins".
Deadline for manuscript submissions: 31 May 2025 | Viewed by 553
Special Issue Editors
Interests: E. coli pathogenicity; antibodies, diagnosis, emerging and reemerging diseases
Interests: hemolytic uremic syndrome; Shiga toxin; diagnosis; prevention; treatments; in vivo and in vitro models
Special Issue Information
Dear Colleagues,
In microbiology, the term “toxin” refers to any substance of microbial origin capable of disrupting host–cell metabolism, often with harmful consequences for the affected organism. Since the isolation of the diphtheria toxin at the end of the 19th century, bacterial toxins have been recognized as key virulence factors responsible for causing diseases. The primary symptoms associated with diseases such as diphtheria (caused by Corynebacterium diphtheriae), whooping cough (caused by Bordetella pertussis), cholera (caused by Vibrio cholerae), botulism (caused by Clostridium botulinum), tetanus (caused by Clostridium tetani), and bloody diarrhea and hemolytic uremic syndrome (caused by Shiga toxin-producing Escherichia coli), among others, are linked to the activity of bacterial toxins. Antibodies are crucial and ubiquitous molecules in the immune system. Due to their high specificity and ability to recognize and bind to antigens, they play a pivotal role in mediating interactions with other immune system components. This unique specificity makes antibodies highly attractive for various applications, including studying in vitro and in vivo toxin pathways, detecting and diagnosing bacterial toxins, and developing therapeutic interventions. The main aim of this Special Issue is to provide an update on the role of antibodies in neutralizing bacterial toxins, contextualizing the intoxication process, and exploring how antibodies can be leveraged as therapeutic tools. Additionally, it will cover the use of antibodies in understanding toxin pathways and their application in diagnosing diseases caused by toxin-producing bacteria.
Dr. Roxane Maria Fontes Piazza
Dr. María M. Amaral
Guest Editors
Manuscript Submission Information
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Keywords
- bacterial toxins
- mechanism of action
- antibodies
- neutralization
- detection
- diagnosis
- in vivo and in vitro models
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