A Clinical-Genetic Score for Predicting Weight Loss after Bariatric Surgery: The OBEGEN Study

Ciudin, Andreea; Fidilio, Enzamaría; Gutiérrez-Carrasquilla, Liliana; Caixàs, Assumpta; Vilarrasa, Núria; Pellitero, Silvia; Simó-Servat, Andreu; Vilallonga, Ramon; Ruiz, Amador; de la Fuente, Maricruz; Luna, Alexis; Sánchez, Enric; Rigla, Mercedes; Hernández, Cristina; Salas, Eduardo; Simó, Rafael; Lecube, Albert

doi:10.3390/jpm11101040

Open AccessArticle

A Clinical-Genetic Score for Predicting Weight Loss after Bariatric Surgery: The OBEGEN Study

by

Andreea Ciudin

^1,2,3,†

,

Enzamaría Fidilio

^1,2,†,

Liliana Gutiérrez-Carrasquilla

⁴,

Assumpta Caixàs

^5,6

,

Núria Vilarrasa

^3,7,

Silvia Pellitero

⁸,

Andreu Simó-Servat

⁷,

Ramon Vilallonga

⁹,

Amador Ruiz

⁹

,

Maricruz de la Fuente

¹⁰,

Alexis Luna

¹¹,

Enric Sánchez

⁴

,

Mercedes Rigla

^5,6,

Cristina Hernández

^1,2,3

,

Eduardo Salas

¹²,

Rafael Simó

^1,2,3,*

and

Albert Lecube

^3,4,*

¹

Endocrinology and Nutrition Department, Hospital Universitari Vall d’Hebron, 08035 Barcelona, Spain

²

Diabetes and Metabolism Research Unit, Vall d’Hebron Institut de Recerca (VHIR), Universitat Autònoma de Barcelona, 08025 Barcelona, Spain

³

Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III (ISCIII), 28029 Madrid, Spain

⁴

Endocrinology and Nutrition Department, Hospital Universitari Arnau de Vilanova, Obesity, Diabetes and Metabolism Research Group (ODIM), Institut de Recerca Biomèdica de Lleida (IRBLleida), Universitat de Lleida, 25198 Lleida, Spain

⁵

Endocrinology and Nutrition Department, Hospital Universitari Parc Tauli, Medicine Department, Universitat Autònoma de Barcelona, Institut d’Investigació i Innovació Parc Taulí, 08208 Sabadell, Spain

⁶

Centro de Investigación Biomédica en Red de la Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III (ISCIII), 28029 Madrid, Spain

⁷

Department of Endocrinology, Diabetes and Nutrition, Bellvitge University Hospital-IDIBELL, L’Hospitalet de Llobregat, 08907 Barcelona, Spain

⁸

Endocrine and Nutrition Department, Germans Trias i Pujol University Hospital, Germans Trias i Pujol Research Institute (IGTP), 08916 Badalona, Spain

⁹

Endocrine, Metabolic and Bariatric Unit, Department of General and Digestive Surgery, Vall d’Hebron University Hospital, Universitat Autònoma de Barcelona, Center of Excellence for the EAC-BS, 08035 Barcelona, Spain

¹⁰

General and Digestive Surgery Department, Hospital Universitari Arnau de Vilanova, Institute de Recerca Biomèdica de Lleida, 25198 Lleida, Spain

¹¹

Surgery Department, Esofago-Gastric Surgery Section, Hospital Universitari Parc Taulí, Institut d’Investigació i Innovació Parc Taulí, 08208 Sabadell, Spain

¹²

Scientific Department, Gendiag, 08028 Barcelona, Spain

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^*

Authors to whom correspondence should be addressed.

^†

A.C. and E.F. have contributed equally to this work.

J. Pers. Med. 2021, 11(10), 1040; https://doi.org/10.3390/jpm11101040

Submission received: 13 September 2021 / Revised: 11 October 2021 / Accepted: 12 October 2021 / Published: 17 October 2021

(This article belongs to the Special Issue Obesity and Diabetes: Genetic Markers and Pharmacological Interventions)

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Abstract

Around 30% of the patients that undergo bariatric surgery (BS) do not reach an appropriate weight loss. The OBEGEN study aimed to assess the added value of genetic testing to clinical variables in predicting weight loss after BS. A multicenter, retrospective, longitudinal, and observational study including 416 patients who underwent BS was conducted (Clinical.Trials.gov- NCT02405949). 50 single nucleotide polymorphisms (SNPs) from 39 genes were examined. Receiver Operating Characteristic (ROC) curve analysis were used to calculate sensitivity and specificity. Satisfactory response to BS was defined as at nadir excess weight loss >50%. A good predictive model of response [area under ROC of 0.845 (95% CI 0.805–0.880), p < 0.001; sensitivity 90.1%, specificity 65.5%] was obtained by combining three clinical variables (age, type of surgery, presence diabetes) and nine SNPs located in ADIPOQ, MC4R, IL6, PPARG, INSIG2, CNR1, ELOVL6, PLIN1 and BDNF genes. This predictive model showed a significant higher area under ROC than the clinical score (p = 0.0186). The OBEGEN study shows the key role of combining clinical variables with genetic testing to increase the predictability of the weight loss response after BS. This finding will permit us to implement a personalized medicine which will be associated with a more cost-effective clinical practice.

Keywords: obesity; bariatric surgery; weight loss; genetics; polygenic risk

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MDPI and ACS Style

Ciudin, A.; Fidilio, E.; Gutiérrez-Carrasquilla, L.; Caixàs, A.; Vilarrasa, N.; Pellitero, S.; Simó-Servat, A.; Vilallonga, R.; Ruiz, A.; de la Fuente, M.; et al. A Clinical-Genetic Score for Predicting Weight Loss after Bariatric Surgery: The OBEGEN Study. J. Pers. Med. 2021, 11, 1040. https://doi.org/10.3390/jpm11101040

AMA Style

Ciudin A, Fidilio E, Gutiérrez-Carrasquilla L, Caixàs A, Vilarrasa N, Pellitero S, Simó-Servat A, Vilallonga R, Ruiz A, de la Fuente M, et al. A Clinical-Genetic Score for Predicting Weight Loss after Bariatric Surgery: The OBEGEN Study. Journal of Personalized Medicine. 2021; 11(10):1040. https://doi.org/10.3390/jpm11101040

Chicago/Turabian Style

Ciudin, Andreea, Enzamaría Fidilio, Liliana Gutiérrez-Carrasquilla, Assumpta Caixàs, Núria Vilarrasa, Silvia Pellitero, Andreu Simó-Servat, Ramon Vilallonga, Amador Ruiz, Maricruz de la Fuente, and et al. 2021. "A Clinical-Genetic Score for Predicting Weight Loss after Bariatric Surgery: The OBEGEN Study" Journal of Personalized Medicine 11, no. 10: 1040. https://doi.org/10.3390/jpm11101040

APA Style

Ciudin, A., Fidilio, E., Gutiérrez-Carrasquilla, L., Caixàs, A., Vilarrasa, N., Pellitero, S., Simó-Servat, A., Vilallonga, R., Ruiz, A., de la Fuente, M., Luna, A., Sánchez, E., Rigla, M., Hernández, C., Salas, E., Simó, R., & Lecube, A. (2021). A Clinical-Genetic Score for Predicting Weight Loss after Bariatric Surgery: The OBEGEN Study. Journal of Personalized Medicine, 11(10), 1040. https://doi.org/10.3390/jpm11101040

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A Clinical-Genetic Score for Predicting Weight Loss after Bariatric Surgery: The OBEGEN Study

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