Search Results (27,433)

Seed dormancy is a key ecological attribute influencing germination timing and the ability of species to establish in variable environments. This study investigated whether inter-population variability in seed dormancy expression exists in Lonicera etrusca, a Mediterranean shrub known for producing seeds with underdeveloped embryos and multiple dormancy types. Seeds were collected from four geographically and ecologically distinct populations in central Iberia and subjected to a series of germination experiments simulating natural seasonal temperature regimes, stratification treatments, and gibberellic acid application. Across all populations, seeds exhibited morphological dormancy (MD) and varying degrees of morphophysiological dormancy (MPD), including non-deep simple and deep complex types. Despite high intra-specific variability in dormancy expression, no significant differences were found among populations for germination patterns or embryo growth responses. This indicates that dormancy variability is an intrinsic, conserved feature of the species rather than a locally adaptive trait. The homogenization of germination strategies across populations may be facilitated by bird-mediated seed dispersal, promoting gene flow and limiting local selection. These findings support the hypothesis that dormancy polymorphism in L. etrusca reflects a flexible germination strategy that enhances colonization potential across heterogeneous Mediterranean environments, rather than an environmentally induced plastic response. Full article

Background: Antimicrobial resistance (AMR) remains a critical major public health challenge, largely driven by the inappropriate use of antibiotics in the community. In Spain, the National Action Plan on AMR (PRAN) emphasizes the need for robust surveillance systems based on standardized indicators and high-quality data sources. Objective: This study aimed to evaluate the feasibility of calculating PRAN prescribing indicators using the National Electronic Database for Pharmacoepidemiological Research in Primary Care (BIFAP) and to validate BIFAP as a data source for national antimicrobial prescribing surveillance. Methods: A population-based cross-sectional study was conducted using 2018 data from 9.4 million individuals. Results: Overall, 23.3% received at least one antibiotic prescription during the year, with an average of 1.8 treatments per patient. First-line recommended antibiotics represented 26.5% of total dispensed defined daily doses. Notable age-related variability in prescribing patterns was observed: children predominantly received first-line narrow-spectrum antibiotics, whereas older adults were more frequently prescribed broad-spectrum agents. Discusion: BIFAP-based indicators closely aligned with PRAN data while allowing for the calculation of additional metrics, such as prevalence of use, treatments per patient-year, and variations by age and sex. The findings underscore the importance of patient-level monitoring to identify demographic-age-specific priorities for targeted interventions aimed at optimizing antibiotic use in Primary Care. Conclusions: This study confirms the feasibility of using BIFAP to strengthen antibiotic consumption monitoring and policy evaluation efforts in Spain. Full article

Continuous urban land development is causing environmental changes. The most visible effects are a decline in biodiversity, an increase in urban temperatures, and changes in the water balance. Recently, very intense and sudden rainfall events have been observed, and existing drainage systems are not effective enough. Urban surfaces tend to be impermeable with low retention, so there is no way to respond to both the rainy periods and the drought periods that often follow. A good remedy for these factors is urban greening, which can be achieved through the design of green roofs and living walls. The substrate used for this type of construction should be light, permeable, and retentive. This study aimed to produce artificial aggregate granules with various additives that modify the structure to create open mesopores and facilitate better rainwater management. Through suitable sintering, materials with water absorption of more than 40%, retention in simulated rainfall of over 35% and a bulk density of ~0.70 g/cm³ were obtained. Detailed microstructural analyses were carried out using various microscopic techniques. Strength tests and simple vegetation tests were also carried out. Full article

Background/Objectives: This study aimed to develop and validate a Dietary Practices and Food Safety Literacy Scale comprehensively assessing competencies among Korean older adults in healthy dietary practices, hygiene, and food safety. Methods: Item development was informed by a literature review, national dietary guidelines, and existing literacy frameworks. Content validity was reviewed by a 10-member expert panel using the Delphi method. Construct validity was tested using exploratory factor analyses (EFA) and confirmatory factor analyses (CFA), and reliability was assessed through Cronbach’s α, composite reliability (CR), and average variance extracted (AVE). Results: EFA identified three factors—management, decision-making, and moderation competencies—comprising 13 items. Internal consistency was acceptable (α = 0.69–0.83), and CFA supported the three-factor structure (CFI = 0.919, RMSEA = 0.087). CR values exceeded 0.70, and AVE were close to or exceeded the recommended threshold. Conclusions: The scale demonstrates sound psychometric properties and provides a practical tool for identifying competency gaps in Dietary Practices and Food Safety Literacy. Its application may guide tailored health education and community-based interventions to promote healthy aging and support public health strategies in aging societies. By translating health information literacy into measurable, behavior-oriented domains, this tool bridges the gap between theoretical constructs and practical assessment. It can be incorporated into routine health monitoring, enabling policymakers and practitioners to design evidence-based interventions that enhance older adults’ dietary self-management and food safety awareness. Full article

In the context of intensifying climate change, it is particularly important to assess the transformation of spring floods as a key phase of the hydrological regime of rivers. This study provides a comprehensive analysis of the characteristics of maximum runoff in the Zhaiyk–Caspian basin for the modern period and projected changes for 2030, 2040, and 2050 based on CMIP6 climate scenarios (SSP3-7.0 and SSP5-8.5). Analysis of observations at 34 hydrological stations showed a reduction in spring runoff by up to 35%, a decrease in the duration of high water and a reduction in maximum water discharge on some rivers by up to 45%. It has been established that those rising temperatures, more frequent thaws, and reduced autumn moisture lead to lower maximum water discharge and a redistribution of the seasonal flow regime. Scenario projections revealed significant spatial heterogeneity: some rivers are expected to experience an increase in maximum discharge of up to 72%, while others will see a steady decline in maximum discharge of up to 35%. The results obtained indicate the need to transition to an adaptive water management system focused on the regional characteristics of river basins and the sensitivity of small- and medium-sized watercourses to climate change. Full article

Autonomous vehicles (AVs) hold strong potential to redefine traffic operations, yet their impacts at varying penetration levels within mixed traffic remain insufficiently quantified. This study evaluates the influence of SAE Level 5 AVs on traffic performance at two typical urban signalized intersections using a hybrid microsimulation approach that integrates behavioral AV modeling and performance evaluation. The analysis covers two typical intersection layouts, one with two through lanes and another with three, tested under varying traffic volumes and left-turn shares. A total of 324 simulation scenarios were conducted with AV penetration ranging from 0% to 100% (in 20% increments) and left-turn proportions of 15%, 30%, and 45%. The results show that 100% AV penetration lowers the average delay by up to 40% in the two-lane intersection scenario and 32% in the three-lane scenario, relative to the 0% AV baseline. Even 20% AV penetration yields about half of the maximum improvement. The greatest benefits occur with aggressive AV driving profiles, balanced approach volumes, and small left-turn shares. These findings provide preliminary evidence of AVs’ potential to enhance intersection efficiency and support Sustainable Development Goals (SDGs) 11 and 13, offering insights to guide intersection design and AV deployment strategies for data-driven, sustainable urban mobility. Full article

The rural population in semi-arid areas of Mexico suffers from poverty levels that hinder a dignified life, leading to migration and abandonment of their resources. This is exacerbated by climate change (droughts and high temperatures), which negatively impacts crops. While farmers attempt to adapt, their strategies are insufficient. A low-cost Complementary Agriculture (AgriCom) model was designed, using local resources to produce prickly pear (Opuntia ficus-indica Mill.) and corn (Zea mays L.), while simultaneously conserving regional germplasm of Opuntia spp. A randomized block design with three replications was used. Each block included seven varieties, with 125 plants per variety. Corn was grown as a monocrop in the same experimental site. Graphical analysis, analysis of variance with mean comparison test in RStudio, a profitability analysis, and a Land Equivalent (ELU) analysis were performed. The varieties Verdura, Atlixco, and Rojo Liso showed higher yield, internal rate of return, and net present value; their benefit–cost ratios were 7.97, 6.35, and 6.82, respectively. The ELU was greater than 1.0 when combining the prickly pear varieties. Agroclimatic conditions did not allow the corn to complete its phenological cycle, and its ELU was zero. Seventy prickly pear genotypes, with three replicates each, representing eight Opuntia species, were collected and integrated into the periphery of the production unit. This model was accepted by the Climate Action Platform for Agriculture in Latin America and the Caribbean (PLACA) for implementation in other communities. Full article

PostCOVID-19 is a condition affecting approximately 10% of individuals infected with SARS-CoV-2, presenting significant challenges in diagnosis and clinical management. Portable neuroimaging techniques, such as functional near-infrared spectroscopy (fNIRS), offer real-time insights into cerebral hemodynamics and represent a promising tool for studying postCOVID-19 in naturalistic settings. This study investigates the integration of fNIRS with machine learning to identify neural correlates of postCOVID-19. A total of six machine learning classifiers—Random Forest, Support Vector Machine (SVM), K-Nearest Neighbors (KNNs), XGBoost, Logistic Regression, and Multi-Layer Perceptron (MLP)—were evaluated using a stratified subject-aware cross-validation scheme on a dataset comprising 29,737 time-series samples from 37 participants (9 postCOVID-19, 28 controls). Four different feature representation strategies were compared: raw time-series, PCA-based dimensionality reduction, statistical feature extraction, and a hybrid approach that combines time-series and statistical descriptors. Among these, the hybrid representation demonstrated the highest discriminative performance. The SVM classifier trained on hybrid features achieved strong discrimination ($\mathit{ROC}\text{-}\mathit{AUC}$ = 0.909) under subject-aware CV5; at the default threshold, $\mathit{Sensitivity}$ was moderate and $\mathit{Specificity}$ was high, outperforming all other methods. In contrast, models trained on statistical features alone exhibited limited $\mathit{Sensitivity}$ despite high $\mathit{Specificity}$. These findings highlight the importance of temporal information in the fNIRS signal and support the potential of machine learning combined with portable neuroimaging for postCOVID-19 identification. This approach may contribute to the development of non-invasive diagnostic tools to support individualized treatment and longitudinal monitoring of patients with persistent neurological symptoms. Full article

This study investigates the development of biodegradable, scented bio-composite filaments incorporating industrial residues, specifically spent coffee grounds (SCG) and lignin (LI), into a PLA matrix for FDM 3D printing. Two fragrance additives, essential oil (EO) and microencapsulated fragrance powder (FP), were introduced (3%) to enhance sensory properties. The research investigates the effects of filler content (5%, 10%, and 15%) and fragrance additives on the surface chemistry (FTIR), thermal stability (TGA and DSC), mechanical properties (Tensile, flexural and impact), microstructure, and dimensional stability (Water absorption test and thickness swelling). Incorporating industrial residues and additives into PLA reduced the thermal stability, the degradation temperature and the glass transition temperature but increased the residual mass and the crystallinity. The effect of lignin was more pronounced than that of SCG, significantly influencing these thermal properties. Increasing the filler content of spent coffee grounds and lignin also led to a progressive decrease in tensile, flexural, and impact strength due to poor interfacial adhesion and increased void formation. However, lignin-based biocomposites exhibited enhanced stiffness at lower concentrations (≤10%), while biocomposites containing 15% SCG doubled their elongation at break compared to pure PLA. Adding fragrance reduced the mechanical strength but improved ductility due to plasticizer-like interactions. Microstructural analysis revealed heterogeneity in the biocomposites’ fracture surface characterized by the presence of pores, filler agglomeration, and delamination, indicating uneven filler dispersion and limited interfacial adhesion, particularly at high filler concentrations. The water absorption and dimensional stability of 3D-printed biocomposites increased progressively with the addition of residues. The presence of essential oil slightly improved water resistance by forming hydrogen bonds that limited moisture absorption. This article adds significant value by extending the potential applications of biocomposites beyond conventional engineering uses, making them particularly suitable for the fashion and design sectors, where multi-sensory and sustainable materials are increasingly sought after. Full article

Electrodes and electrolytes are critical components for the performance of supercapacitors. In this study, supercapacitors with different interfaces were assembled using polypyrrole (PPy) or a polypyrrole–carbon nanotube (PPy-CNT) composite as active materials, and dimethyl sulfoxide (DMSO) and sodium chloride (NaCl) were used as electrolytes. Electrochemical measurements were obtained by cyclic voltammetry (CV) at a scan rate of 20 mV/s and galvanostatic charge–discharge (GCD) measurements at a scan rate of 50 µA/s. The results suggest that the supercapacitor with a PPy-CNT composite and NaCl electrolyte has promising electrochemical characteristics. Full article

Omega-3 and omega-6 fatty acids play essential roles in human health, being widely used in the prevention and treatment of various conditions, such as cardiovascular diseases, inflammation, and metabolic disorders. However, their oral administration faces significant challenges, including low solubility, rapid oxidation, and low bioavailability, which limit their therapeutic efficacy. This article explores recent advances in oral drug delivery systems designed for polyunsaturated fatty acids, highlighting how innovative technologies, such as nanoemulsions, liposomes, microencapsulation, and solid lipid nanoparticles (SLNs/NLCs), can improve their stability, absorption and clinical performance. In addition, the main natural sources of these compounds, as well as their extraction and purification methods, and the challenges related to their absorption and metabolism are discussed. This narrative review was based mainly on a comprehensive search of peer-reviewed literature published between 2015 and 2025 in PubMed, Scopus, and Web of Science. The therapeutic benefits of these emerging approaches are analyzed by comparing conventional methods with modern delivery strategies to optimize the use of omega-3 and omega-6 in the body. Finally, the article outlines future perspectives and regulatory challenges associated with these technologies, highlighting their potential to revolutionize the administration of essential fatty acids and broaden their applications in medicine and nutrition. Full article

Integrated pest management (IPM) in tomato (Solanum lycopersicum L.) on the Ecuadorian coast represents a critical challenge, given that pest persistence has led producers to abandon the crop, generating significant losses. This study compared pest population fluctuations in greenhouse and open field conditions under realistic management conditions and free infestation, considering the influence of environmental factors and applications of biorational, semisynthetic, and synthetic pesticides. In open fields, infestations were high and sustained, exceeding treatment thresholds, while in greenhouses, levels were lower, attributable to the protection of the aphid netting. Product efficacy depended on the pest and the level of infestation: Azadirachta indica, Bacillus thuringiensis, and Beauveria bassiana were effective in low infestations; spinetoram and abamectin reached efficacies between 80 and 100% in moderate infestations; neonicotinoids had variable efficacy, ranging from 47.8% to 89.9%. Since the system determines the type of pest and the level of infestation, monitoring becomes a key tool for timely decision-making. The findings show that the greenhouse limits the entry of the main pest, Prodiplosis longifila. While it does not prevent the presence of smaller pests, such as thrips and white mites, the combination of physical barriers and low-toxicity pesticides significantly reduces populations, minimizing the number of applications and the use of more toxic insecticides. The proposed strategy provides solid evidence for the effective implementation of a greenhouse to reduce pest pressure and promote IPM in protected coastal systems in Ecuador. Full article

Introduction: Patellofemoral osteoarthritis (PFOA) remains a therapeutic challenge with few effective non-surgical options. Objective: The aim of this study was to evaluate the feasibility, safety, and preliminary outcomes of ultrasound (US)-guided tibial endplate aspiration and intra-articular injection of bone marrow concentrate (BMC) in patients with isolated PFOA. Methods: In this retrospective case series, seven consecutive patients with symptomatic PFOA unresponsive to conservative therapy were treated with US-guided tibial endplate aspiration followed by intra-articular BMC injection. Clinical outcomes were assessed with the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) at baseline and 12 months. MRI with T2 mapping was performed to evaluate cartilage structure. BMC composition was analyzed, including colony-forming unit fibroblast (CFU-F) assays. Results: The procedures were feasible in all cases, and no adverse events occurred. WOMAC scores improved significantly from 21.7 ± 17.3 at baseline to 9.0 ± 9.3 at 12 months (p = 0.030). MRI showed a mean relative increase of 25.4% ± 43.5% in healthy cartilage volume, though this was not statistically significant (p = 0.49). Correlation analyses revealed no consistent association between clinical response and cellular composition, including estimated MSC dose. Conclusions: This small retrospective series suggests that US-guided tibial endplate aspiration and intra-articular BMC injection are safe, technically feasible, and may provide clinical benefit in isolated PFOA. Larger controlled studies are needed to confirm these preliminary findings. Full article

Ruta chalepensis (Rutaceae), commonly known as rue, is traditionally recognized for its medicinal applications and cultural associations with mysticism. In addition to its ethnobotanical relevance, R. chalepensis has been reported to possess insect-repellent and pesticidal properties. However, domestication and the adoption of monoculture practices can compromise inherent plant defenses, potentially increasing susceptibility to herbivore pressure. In this context, we report, for the first time, the occurrence of infestations by the highly polyphagous aphid Myzus persicae (Sulzer) (Hemiptera: Aphididae) on R. chalepensis cultivated under Neotropical conditions. The infestations were documented in commercial rue fields located in the Zona da Mata region, Minas Gerais, Brazil, in two consecutive years. Plant material was taxonomically verified and deposited in the VIC Herbarium at the Universidade Federal de Viçosa. Aphid specimens, including both apterous and alate morphs, were examined under a stereomicroscope to confirm species identity. Field sampling revealed a notable interaction between M. persicae and native natural enemies, particularly predatory spiders. Aphid density per plant declined markedly from 14.1 to 6.2 individuals, coinciding with an observed increase in spider activity. These findings expand our understanding of M. persicae’s ecological plasticity and highlight the vulnerability of non-conventional crops to generalist pests. They also underscore the importance of implementing targeted pest surveillance and integrated pest management (IPM) approaches in underutilized or alternative cropping systems. Full article