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Keywords = Aspergilosis

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7 pages, 401 KB  
Article
Antifungal Resistance in Clinical Isolates of Aspergillus spp.: When Local Epidemiology Breaks the Norm
by Mercedes Romero, Fernando Messina, Emmanuel Marin, Alicia Arechavala, Roxana Depardo, Laura Walker, Ricardo Negroni and Gabriela Santiso
J. Fungi 2019, 5(2), 41; https://doi.org/10.3390/jof5020041 - 21 May 2019
Cited by 26 | Viewed by 4382
Abstract
Aspergillosis is a set of very frequent and widely distributed opportunistic diseases. Azoles are the first choice for most clinical forms. However, the distribution of azole-resistant strains is not well known around the world, especially in developing countries. The aim of our study [...] Read more.
Aspergillosis is a set of very frequent and widely distributed opportunistic diseases. Azoles are the first choice for most clinical forms. However, the distribution of azole-resistant strains is not well known around the world, especially in developing countries. The aim of our study was to determine the proportion of non-wild type strains among the clinical isolates of Aspergillus spp. To this end, the minimum inhibitory concentration of three azoles and amphotericin B (used occasionally in severe forms) was studied by broth microdilution. Unexpectedly, it was found that 8.1% of the isolates studied have a diminished susceptibility to itraconazole. This value turned out to be similar to the highest azole resistance rate reported in different countries across the world. Full article
(This article belongs to the Special Issue Fungal Epidemiology)
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