Search Results (985)

Migraine is a complex neurovascular disorder in which immune signaling intersects with vascular and neural circuits, yet the tissue and cell-type context of common genetic risk remains incompletely defined. We integrated large-scale migraine genome-wide association study (GWAS) summary statistics with Genotype-Tissue Expression (GTEx) v8 expression and splicing quantitative trait loci (eQTLs and sQTLs), Bayesian co-localization, single-cell RNA sequencing of peripheral blood mononuclear cells (PBMCs) from migraine cases and controls, a healthy single-cell multi-omics atlas (assay for transposase-accessible chromatin (ATAC) plus RNA), high-dimensional weighted gene co-expression network analysis (hdWGCNA), and embryo-level spatial transcriptomics. Genetic signals were enriched in peripheral arteries, heart, and blood, and gene-level enrichment highlighted mucosal–smooth muscle organs including the bladder and the cervix endocervix. Cell-type prioritization consistently implicated endothelial and vascular smooth muscle lineages, with additional support for inhibitory interneurons and bladder epithelium. In PBMC T cells, co-expression modules capturing cytotoxic/activation and T-cell receptor signaling programs contained migraine-prioritized genes, including PTK2B, nominating immune activation circuitry as a component of genetic susceptibility. Spatial projection further localized risk concordance to craniofacial/meningeal interfaces and visceral smooth muscle–mucosal structures. Together, these analyses delineate a systemic neuroimmune–vascular architecture for migraine and provide genetically anchored candidate pathways and targets for mechanistic and therapeutic follow-up. Full article

Artificial intelligence transforms lubricant research by linking molecular modeling, diagnostics, and industrial operations into predictive systems. In this regard, machine learning methods such as Bayesian optimization and neural-based Quantitative Structure–Property/Tribological Relationship (QSPR/QSTR) modeling help to accelerate additive design and formulation development. Moreover, deep learning and hybrid physics–AI frameworks are now capable to predict key lubricant properties such as viscosity, oxidation stability, and wear resistance directly from molecular or spectral data, reducing the need for long-duration field trials like fleet or engine endurance tests. With respect to condition monitoring, convolutional neural networks automate wear debris classification, multimodal sensor fusion enables real-time oil health tracking, and digital twins provide predictive maintenance by forecasting lubricant degradation and optimizing drain intervals. AI-assisted blending and process control platforms extend these advantages into manufacturing, reducing waste and improving reproducibility. This article sheds light on recent progress in AI-driven formulation, monitoring, and maintenance, thus identifying major barriers to adoption such as fragmented datasets, limited model transferability, and low explainability. Moreover, it discusses how standardized data infrastructures, physics-informed learning, and secure federated approaches can advance the industry toward adaptive, sustainable lubricant development under the principles of Industry 5.0. Full article

The unique geographical isolation and climate sensitivity of island ecosystems make them valuable for ecological research. The Normalized Difference Vegetation Index (NDVI) is an important indicator when monitoring and evaluating these systems, and its prediction has become a key research focus. However, island NDVI prediction remains uncertain due to a limited understanding of vegetation growth and insufficient high-quality data. Deterministic models fail to capture or quantify such uncertainty, often leading to overfitting. To address this issue, this study proposes an uncertainty prediction model for the island NDVI within a coding–prediction–decoding framework, referred to as a Convolutional Autoencoder–Regularized Bayesian Neural Network (CAE-RBNN). The model integrates a convolutional autoencoder with feature regularization to extract latent NDVI features, aiming to reconcile spatial scale disparities with environmental data, while a Bayesian Neural Network (BNN) quantifies uncertainty arising from limited samples and an incomplete understanding of the process. Finally, Monte Carlo sampling and SHAP analysis evaluate model performance, quantify predictive uncertainty, and enhance interpretability. Experiments on six islands in the Xisha archipelago demonstrate that CAE-RBNN outperforms the Convolutional Neural Network–Recurrent Neural Network (CNN-RNN), the Convolutional Recurrent Neural Network (ConvRNN), Convolutional Long Short-Term Memory (ConvLSTM), and Random Forest (RF). Among them, CAE-RBNN reduces the MAE and MSE of the single-time-step prediction task by 8.40% and 10.69%, respectively, compared with the suboptimal model and decreases them by 16.31% and 22.57%, respectively, in the continuous prediction task. More importantly, it effectively quantifies the uncertainty of different driving forces, thereby improving the reliability of island NDVI predictions influenced by the environment. Full article

Neutral atomic hydrogen (H I) regulates galaxy growth and quenching, but direct 21 cm measurements remain observationally expensive and affected by selection biases. We develop Bayesian neural networks (BNNs)—a type of neural model that returns both a prediction and an associated uncertainty—to infer the H I mass, ${log}_{10}\left(M_{\mathrm{HI}}\right)$, from widely available optical properties (e.g., stellar mass, apparent magnitudes, and diagnostic colors) and simple structural parameters. For continuity with the photometric gas fraction (PGF) literature, we also report the gas-to-stellar-mass ratio, ${log}_{10}(G/S)$, where explicitly noted. Our dataset is a reproducible cross-match of SDSS DR12, the MPA–JHU value-added catalogs, and the 100% ALFALFA release, resulting in 31,501 galaxies after quality controls. To ensure fair evaluation, we adopt fixed train/validation/test partitions and an additional sky-holdout region to probe domain shift, i.e., how well the model extrapolates to sky regions that were not used for training. We also audit features to avoid information leakage and benchmark the BNNs against deterministic models, including a feed-forward neural network baseline and gradient-boosted trees (GBTs, a standard tree-based ensemble method in machine learning). Performance is assessed using mean absolute error (MAE), root-mean-square error (RMSE), and probabilistic diagnostics such as the negative log-likelihood (NLL, a loss that rewards models that assign high probability to the observed H I masses), reliability diagrams (plots comparing predicted probabilities to observed frequencies), and empirical 68%/95% coverage. The Bayesian models achieve point accuracy comparable to the deterministic baselines while additionally providing calibrated prediction intervals that adapt to stellar mass, surface density, and color. This enables galaxy-by-galaxy uncertainty estimation and prioritization for 21 cm follow-up that explicitly accounts for predicted uncertainties (“risk-aware” target selection). Overall, the results demonstrate that uncertainty-aware machine-learning methods offer a scalable and reproducible route to inferring galactic H I content from widely available optical data. Full article

Coastal waters worldwide are increasingly threatened by excessive nutrient inputs, a key driver of eutrophication. Dissolved inorganic nitrogen (DIN) serves as a vital indicator for assessing the eutrophic status of nearshore marine environments, underscoring the necessity for precise monitoring to ensure effective protection and restoration of marine ecosystems. To address the current limitations in DIN retrieval methods, this study builds on MODIS satellite imagery data and introduces a novel one-dimensional convolutional neural network (1D-CNN) model synergistically co-optimized by the Bald Eagle Search (BES) and Bayesian Optimization (BO) algorithms. The proposed BES-BO-CNN framework was applied to the retrieval of DIN concentrations in the coastal waters of Shandong Province from 2015 to 2024. Based on the retrieval results, we further investigated the spatiotemporal evolution patterns and dominant environmental drivers. The findings demonstrated that (1) the BES-BO-CNN model substantially outperforms conventional approaches, with the coefficient of determination (R²) reaching 0.81; (2) the ten-year reconstruction reveals distinct land–sea gradient patterns and seasonal variations in DIN concentrations, with the Yellow River Estuary persistently exhibiting elevated levels due to terrestrial inputs; (3) correlation analysis indicated that DIN is significantly negatively correlated with sea surface temperature but positively correlated with sea level pressure. In summary, the proposed BES-BO-CNN framework, via the synergistic optimization of multiple algorithms, enables high-precision DIN monitoring, thus providing scientific support for integrated land–sea management and targeted control of nitrogen pollution in coastal waters. Full article

Solving Bayesian inverse problems efficiently stands as a major bottleneck in scientific computing. Although Bayesian Physics-Informed Neural Networks (B-PINNs) have introduced a robust way to quantify uncertainty, the high-dimensional parameter spaces inherent in deep learning often lead to prohibitive sampling costs. Addressing this, our work introduces Quantum-Encodable Bayesian PINNs trained via Classical Ensemble Kalman Inversion (QEKI), a framework that pairs Quantum Neural Networks (QNNs) with Ensemble Kalman Inversion (EKI). The core advantage lies in the QNN’s ability to act as a compact surrogate for PDE solutions, capturing complex physics with significantly fewer parameters than classical networks. By adopting the gradient-free EKI for training, we mitigate the barren plateau issue that plagues quantum optimization. Through several benchmarks on 1D and 2D nonlinear PDEs, we show that QEKI yields precise inversions and substantial parameter compression, even in the presence of noise. While large-scale applications are constrained by current quantum hardware, this research outlines a viable hybrid framework for including quantum features within Bayesian uncertainty quantification. Full article

Carbon capture and storage (CCS) is essential for achieving net-zero emissions, yet amine-based capture systems face significant challenges including high energy penalties (20–30% of power plant output) and operational costs ($50–120/tonne CO${}_2$). This study develops and validates a novel multi-scale Digital Twin (DT) framework integrating Physics-Informed Neural Networks (PINNs) to address these challenges through real-time optimization. The framework combines molecular dynamics, process simulation, computational fluid dynamics, and deep learning to enable real-time predictive control. A key innovation is the sequential training algorithm with domain decomposition, specifically designed to handle the nonlinear transport equations governing CO${}_2$ absorption with enhanced convergence properties.The algorithm achieves prediction errors below 1% for key process variables (R${}^2$> 0.98) when validated against CFD simulations across 500 test cases. Experimental validation against pilot-scale absorber data (12 m packing, 30 wt% MEA) confirms good agreement with measured profiles, including temperature (RMSE = 1.2 K), CO${}_2$ loading (RMSE = 0.015 mol/mol), and capture efficiency (RMSE = 0.6%). The trained surrogate enables computational speedups of up to four orders of magnitude, supporting real-time inference with response times below 100 ms suitable for closed-loop control. Under the conditions studied, the framework demonstrates reboiler duty reductions of 18.5% and operational cost reductions of approximately 31%. Sensitivity analysis identifies liquid-to-gas ratio and MEA concentration as the most influential parameters, with mechanistic explanations linking these to mass transfer enhancement and reaction kinetics. Techno-economic assessment indicates favorable investment metrics, though results depend on site-specific factors. The framework architecture is designed for extensibility to alternative solvent systems, with future work planned for industrial-scale validation and uncertainty quantification through Bayesian approaches. Full article

This work implements deep learning models to capture non-linear and complex data behavior in aluminum price data. Deep learning models include the long short-term memory (LSTM) and deep feedforward neural networks (FFNN). The support vector regression (SVR) is employed as a base model for comparison. Each predictive model is tuned by using two different optimization methods: Bayesian optimization (BO) and random search (RS). All models are tested on daily, weekly, and monthly data. Three performance metrics are used to evaluate each forecasting model: the root mean squared error (RMSE), mean absolute error (MAE), and the coefficient of determination (R²). The experimental results show that the LSTM-BO is the best-performing model across the time horizons (daily, weekly, and monthly). By consistently achieving the lowest RMSE, MAE, and highest R², the LSTM-BO outperformed all the other models, including SVR-BO, FFNN-BO, LSTM-RS, SVR-RS, and FFNN-RS. In addition, predictive models utilizing BO regularly outperformed those using RS. In summary, LSTM-BO is highly beneficial for aluminum spot price forecasting. Full article

Deep learning has emerged as a transformative methodology in modern cosmology, providing powerful tools to extract meaningful physical information from complex astronomical data. This paper implements a novel Bayesian graph deep learning framework for estimating key cosmological parameters in a primordial magnetic field (PMF) cosmology from simulated Cosmic Microwave Background (CMB) maps. Our methodology utilizes DeepSphere, a spherical convolutional neural network architecture specifically designed to respect the spherical geometry of CMB data through HEALPix pixelization. To advance beyond deterministic point estimates and enable robust uncertainty quantification, we integrate Bayesian Neural Networks (BNNs) into the framework, capturing aleatoric and epistemic uncertainties that reflect the model confidence in its predictions. The proposed approach demonstrates exceptional performance, achieving $R^2$ scores exceeding 89% for the magnetic parameter estimation. We further obtain well-calibrated uncertainty estimates through post hoc training techniques including Variance Scaling and GPNormal. This integrated DeepSphere-BNNs framework delivers accurate parameter estimation from CMB maps with PMF contributions while providing reliable uncertainty quantification, enabling robust cosmological inference in the era of precision cosmology. Full article

Background: Coronavirus disease 2019 (COVID-19) vaccines deliver mRNA packaged in lipid nanoparticles via intramuscular injection. This study investigated several factors influencing antibody production patterns and adverse reactions after vaccination with COVID-19 vaccines. Methods: Among the participants of the Iwaki Health Promotion Project (IHPP), 211 individuals who consented to this study were surveyed regarding antibody titers and adverse reaction symptoms following vaccination. A machine learning approaches such as ridge regression, elastic-net, light gradient boosting, and neural network were applied to extract the variables, and Bayesian network analysis was applied to explore causal relationships between health data and the multi-omics dataset obtained from the IHPP health checkups. Results: Females with lower levels of free testosterone experienced more adverse reactions than males. Moreover, the immune system is more active in younger individuals, causing adverse reactions and higher antibody production. The Spikevax vaccine induced adverse reaction symptoms with higher antibody production in cases of fever. Meanwhile, drinking 2–3 cups of green tea daily seemed to be effective in increasing antibody production. Factors increasing side effect risk include blood natural killer cell count and muscle quality in the vaccinated arm. Plasma metabolome metabolite concentrations, tongue coating bacterial colonization, and folate intake were also identified as factors influencing side effect risk. Furthermore, characteristics of participants at risk for fever symptoms included longer telomere length, higher antibody production patterns, and higher CD4-positive T cell counts. Conclusions: Further investigation of these identified influencing factors is expected to clarify the rationale for new vaccine development and identify lifestyle and dietary habits that enhance vaccine efficacy. Full article

In nanometer integrated-circuit (IC) manufacturing, advanced technology scaling has intensified the effects of process variations on circuit reliability and performance. Random fluctuations in parameters such as threshold voltage, channel length, and oxide thickness further degrade design margins and increase the likelihood of functional failures. These variations often lead to rare circuit failure events, underscoring the importance of accurate yield estimation and robust design methodologies. Conventional Monte Carlo yield estimation is computationally infeasible as millions of simulations are required to capture failure events with extremely low probability. This paper presents a novel reliability-based circuit design optimization framework that leverages deep transfer learning to improve the efficiency of repeated yield analysis in optimization iterations. Based on pre-trained neural network models from prior design knowledge, we utilize model fine-tuning to accelerate importance sampling (IS) for yield estimation. To improve estimation accuracy, adversarial perturbations are introduced to calibrate uncertainty near the model decision boundary. Moreover, we propose a cascaded batch Bayesian optimization (CBBO) framework that incorporates a smart initialization strategy and a localized penalty mechanism, guiding the search process toward high-yield regions while satisfying nominal performance constraints. Experimental validation on SRAM circuits and amplifiers reveals that CBBO achieves a computational speedup of 2.02×–4.63× over state-of-the-art (SOTA) methods, without compromising accuracy and robustness. Full article

The quality and safety of grain and oil food are paramount to sustainable societal development and public health. Implementing early warning analysis and risk control is critical for the comprehensive identification and management of grain and oil food safety risks. However, traditional risk prediction models are limited by their inability to accurately analyze complex nonlinear data, while their reliance on centralized storage further undermines prediction credibility and traceability. This study proposes a deep learning risk prediction model integrated with a blockchain-based traceability mechanism. Firstly, a risk prediction model combining Grey Relational Analysis (GRA) and Bayesian-optimized Tabular Neural Network (TabNet-BO) is proposed, enabling precise and rapid fine-grained risk prediction of the data; Secondly, a risk prediction method combining blockchain and deep learning is proposed. This method first completes the prediction interaction with the deep learning model through a smart contract and then records the exceeding data and prediction results on the blockchain to ensure the authenticity and traceability of the data. At the same time, a storage optimization method is employed, where only the exceeding data is uploaded to the blockchain, while the non-exceeding data is encrypted and stored in the local database. Compared with existing models, the proposed model not only effectively enhances the prediction capability for grain and oil food quality and safety but also improves the transparency and credibility of data management. Full article

The temperature at the base of the ear is highly correlated with the core body temperature of sheep and responds sensitively to febrile conditions, making it a valuable indicator of sheep health. In northern China, the closed housing environment during winter increases the incidence of seasonal diseases such as upper respiratory infections and pneumonia, which severely affect the economic efficiency of sheep farming. To address this issue, this study proposes an early-warning method for winter diseases in sheep based on ear-base temperature. Ear temperature, body weight, and environmental data were collected, and Random Forest was employed for feature selection. Bayesian optimization was used to fine-tune the hyperparameters of a one-dimensional convolutional neural network to construct a predictive model of ear-base temperature using data from healthy sheep. Based on the predicted normal range, an early-warning strategy was established to detect abnormal temperature patterns associated with disease onset. Experimental results demonstrated that the proposed method achieved a high detection rate for common winter diseases while maintaining a low false positive rate, and validation experiments confirmed its effectiveness under practical farming conditions. Combined with low-cost temperature-sensing ear tags, the proposed approach enables real-time health monitoring and provides timely early warnings for winter diseases in large-scale sheep farming, thereby improving management efficiency and economic performance. Full article

To address the limitations of traditional aircraft skin inspection, the aviation industry and academia have increasingly been exploring the integration of computer vision technologies into the defect detection process. These implementations of computer vision technologies rely on the performance of underlying neural network models, whose effectiveness is highly influenced by their hyperparameter configuration. To obtain optimum hyperparameters, an optimization procedure is often employed to optimize a certain combination of the model’s performance metrics. However, in the aircraft skin defect detection domain, studies to inspect the effect of different emphases in the performance metrics considered in this objective function are still not widely available. In this paper, we present our early observations regarding the influence of different performance metrics’ emphases during the hyperparameter tuning process on the overall performance of a computer vision model employed for aircraft skin defect detection. In this preliminary inspection, we consider the utilization of YOLOv12 and the Bayesian Optimization approach for the defect detection model and hyperparameter optimizer, respectively. We highlight the possible performance degradation of the model after a hyperparameter tuning procedure when the weight factor distribution of the performance metrics is not carefully considered. We note several weight factors of interest that could serve as initial possible “safe spots” for further exploration. Full article

This study systematically compares three unsupervised segmentation algorithms (Simple Linear Iterative Clustering (SLIC), Felzenszwalb’s graph-based method, and the Watershed algorithm) in combination with two classification approaches: Random Forest using histogram-based features and Convolutional Neural Networks (CNNs). The study employs Bayesian optimization to jointly tune segmentation parameters and model hyperparameters, investigating how segmentation quality impacts downstream classification performance. The methodology is validated using light optical microscopy images of a high-strength steel sample, with performance evaluated through stratified cross-validation and independent test sets. The findings demonstrate the critical importance of segmentation algorithm selection and provide insights into the trade-offs between feature-engineered and end-to-end learning approaches for microstructure analysis. Full article