Search Results (1,015)

Enterprise decision making in marketing, finance, and audit remains fragmented, leading to inefficient budget allocation and incomplete risk assessment. This study proposes an integrated, Big Data-driven decision-support framework that unifies Large Language Models (LLMs), attention-based marketing mix modeling, and multi-agent, game-theoretic optimization to coordinate cross-functional decisions. The architecture combines five modules: LLM-enhanced customer segmentation and customer lifetime value prediction, attention-weighted marketing mix modeling, multi-agent LLM systems for hierarchical budget optimization, attention-informed Markov multi-touch attribution, and LLM-augmented audit quality assessment. Empirical validation on a large-scale e-commerce dataset with 2.8 million customers and USD 156 million in marketing expenditure shows that marketing return on investment increases from 4.2 to 6.78 (61.4% relative improvement), financial forecasting error (MAPE) decreases from 12.8% to 4.7% (63.3% reduction), fraud detection accuracy improves by 29.8%, the Audit Quality Index reaches 0.951, and customer lifetime value prediction accuracy improves from 76.4% to 91.3%. By operationalizing the convergence of LLMs, attention mechanisms, and game-theoretic reasoning within a unified and empirically validated framework, the study delivers both theoretical advances and practically deployable tools for integrated business intelligence in digital economies. Full article

Spiritual care competence (SCC) is increasingly recognized as relevant in mental health, yet no validated tool exists in Slovenia. This study aimed to translate and validate the Spiritual Care Competence Questionnaire (SCCQ) in a Slovene sample of mental-health professionals. Guided by this aim, our research question was the following: to what extent does the SCCQ demonstrate a replicable seven-factor structure, acceptable reliability, construct validity, and coherent group differences in a Slovene sample of mental-health professionals? In a cross-sectional survey (n = 291) across outpatient, inpatient, private, and other settings, we administered the SCCQ together with measures of spiritual sensitivity (SSS), spiritual transcendence (STS), and the BFI-S. Following forward–backward translation and expert review, we conducted item analysis, exploratory and confirmatory factor analyses, and assessed reliability and construct validity. After removing seven psychometrically weak items, a 35-item, seven-factor structure—perception of spiritual needs, team spirit, documentation/tools, spiritual self-awareness, knowledge of other religions, conversation, and empowerment/proactive opening—showed borderline to acceptable fit (TLI = 0.917, CFI = 0.892, RMSEA = 0.068, SRMR = 0.073) and internal consistency (Cronbach’s alpha = 0.67–0.87). Convergent validity was supported by positive associations with SSS/STS, while expected correlations with Big Five traits were small but significant (negative for Emotional Instability). Older age and psychotherapist profession predicted higher SCC. The Slovene SCCQ is a confession-neutral, psychometrically adequate instrument for assessing SCC in mental-health services. Findings highlight curricular needs—especially documentation/tools and team-based engagement—and enable research, education, and quality improvement aligned with international SCCQ validations. Full article

Candidate interview assessment is primarily reliant on subjective human judgment, while existing AI-based methods rely on end-to-end predictions with no psychometric basis. In this paper, we propose an interpretable multi-modal framework that combines nonverbal behavior, LLM-based verbal analysis, and Big Five personality traits into three theory-based constructs: professional-cognitive competence, observed leadership behavior, and leadership disposition. The proposed method utilizes computer vision and larger language models to extract features from video interviews. Rather than targeting predictive accuracy, the proposed method prioritizes construct validity and transparent aggregation under severe label scarcity. The proposed method aggregates the constructs into a Top Potential Score that reflects the executive abilities of the candidate. Experiments on the method show its ability to significantly differentiate top candidates from others (Cliff’s delta = 0.91 for the composite Top Potential Score, permutation p = 0.0002). Leave-one-out analysis verifies robustness, while rank-based evaluation yields 100% recall of executive candidates in the top 20% of rated applications. The findings justify the use of the proposed multi-modal method as an interpretable decision-support tool for candidate interview assessment. Full article

Existing research confirms associations between Big Five personality traits and emotional states, yet investigations into how personality traits modulate emotional dynamics and their gender-specific patterns remain limited. The present study developed a TFace-Bi-GRU-SE deep learning model that achieved a weighted accuracy of 63.50 ± 0.98% (peak single-run: 64.96%) and an F1 score of 65.21% in performance testing, with a single-inference time of 14.1 s, outperforming traditional methods. The model processed 10 min video recordings from 30 participants (19,262 observations), generating time-series data for valence (P) and arousal (A). Combined with Big Five personality assessments, continuous-time structural equation modeling (CTSEM) revealed distinct emotional dynamics: both P and A exhibited significant negative autoregression (−0.056 and −0.558, p < 0.001), with A reverting to baseline substantially faster (half-life: 1.2 s) than P (half-life: 12.3 s); cross-lagged effects were nonsignificant (P_A: 0.007; A_P: −0.026, p > 0.05). Arousal demonstrated greater instantaneous volatility (=0.339) than valence (=0.286, p < 0.001), with positive covariation between dimensions (0.218, p = 0.006). Exploratory analyses (N = 30) indicated that higher neuroticism and openness scores were associated with elevated arousal (Cohen’s d > 0.8), whereas higher agreeableness and conscientiousness scores were associated with elevated valence (d > 0.8). Gender moderated the neuroticism–arousal relationship, with more potent effects in females (r = 0.746, p = 0.008). Robustness analyses demonstrated high stability of core DRIFT parameters (P_P, A_A): bootstrap resampling (n = 50) yielded coefficients of variation < 0.35 with 100% directional consistency; subgroup validation confirmed cross-sample invariance. Sensitivity analyses revealed that an additional 8% measurement error induced less than 9% bias (8.3% for both P_P and A_A) in autoregressive parameters while preserving half-life ratios, confirming CTSEM’s capacity to extract reliable dynamics from moderately accurate AI outputs. Bootstrap and Bayesian analyses identified ten personality–DRIFT associations with directional consistency ≥ 70%; these constitute preliminary hypotheses for adequately powered future studies (N ≥ 61). This study provides methodological foundations for personalized affective intervention research. Data and code are publicly available (see Data Availability Statement). Full article

Background: This study examined age-related differences and interrelationships among psychological symptoms, personality traits, and emotional expression styles in a community sample of 151 participants aged 10–77 years, spanning four age groups: adolescents, young adults, middle-aged adults, and older adults. Methods: Psychological symptoms were assessed using the SCL-90, personality traits using the Big Five Inventory-2 (BFI-2), and emotional expression patterns were derived from facial expression recognition via a convolutional neural network (CNN) model. Kruskal–Wallis H tests were used to examine age-related differences. K-means cluster analysis was applied to identify emotional expression patterns, and logistic regression was used to construct a mental health risk screening model. Results: The young adult group (19–35 years) achieved the highest scores on the depression (M = 1.73) and anxiety (M = 1.61) dimensions, indicating a higher level of psychological distress during this life stage. Personality traits showed a significant developmental trajectory: neuroticism decreased with age (H(3) = 17.09, p < 0.001, η² = 0.11), declining from 2.69 in the young adult group to 2.17 in the older adult group; conscientiousness increased with age (H(3) = 37.39, p < 0.001, η² = 0.24), representing the most substantial age-related effect. K-means clustering identified three distinct emotional expression patterns: Cluster 1 was characterised by happiness, Cluster 2 by anger, disgust, and fear, and Cluster 3 by neutrality, sadness, and surprise. Cluster 2 exhibited the highest scores on neuroticism, anxiety, depression, and mood swings, and scored significantly higher than the other two clusters on interpersonal sensitivity, depression, anxiety, and hostility (p < 0.05). Mental health risk screening indicated that 26.5% of participants were classified as high-risk. Logistic regression analysis (AUC = 0.742) showed that neuroticism was the strongest predictor of elevated mental health risk (OR = 4.58), while extraversion (OR = 0.41) and conscientiousness (OR = 0.57) were significant protective factors. Conclusions: These findings provide exploratory evidence regarding age-related patterns of psychological symptoms and personality traits in a convenience sample and offer preliminary support for personality-based mental health risk screening. Notably, the SCL-90 was employed as a screening tool rather than for clinical diagnosis. Given the unequal age group sizes, particularly the small young adult subgroup, generalisability across the lifespan should not be assumed. Full article

Research on financial risk tolerance and risk-taking increasingly incorporates personality traits into predictive and descriptive models of risk-taking behavior; however, intercorrelations among traits can obscure the unique contributions of individual traits. This is known as the suppressor effect. This study employed a two-stage analytic framework to test and adjust for suppressor effects across the Big Five personality dimensions in describing financial risk tolerance. In Stage 1, correlation and OLS regression analyses identified suppression patterns, revealing that the explanatory validity of some factors was distorted by shared variance. In Stage 2, suppression-adjusted trait estimates were used to reassess their unique association with financial risk-taking mediated through financial risk tolerance. Results indicate that Openness to Experience and Extraversion are the strongest descriptors of financial risk-taking once suppressor effects are controlled. At the same time, Agreeableness and Conscientiousness contribute modestly and context-dependently to descriptions of financial risk-taking. These findings demonstrate that ignoring suppression effects can lead to mischaracterizing the role of personality in financial decision-making. This study shows that more precise estimates of trait influences can improve theoretical models of investor behavior and enhance the delivery of financial advice and education. Full article

Research using latent profile analysis (LPA) has yielded inconsistent results regarding the number of personality profiles among athletes, the specific configuration of the Big Five traits, and their interpretation. This study seeks to explore personality types by excluding additional variables from the LPA model, aiming to assess how well personality profiles are universal (independent of gender and cultural context) and can predict academic achievement in student athletes. A cross-sectional study was conducted using a paper-and-pencil questionnaire among 424 student athletes from two universities in Poland and Ukraine. The average age of participants was 20 years old (M = 20.01; SD = 2.48), 62% were male, 53% lived in Poland, and 58% studied Sports Sciences vs. 42% Physical Education. The Mini-International Personality Item Pool (Mini-IPIP) was used to assess the Big Five personality traits, and grade point average (GPA) was used to measure students’ academic achievements in the last semester. The LPA identified four personality profiles: (1) Restrained Neurotic (Profile 1, 32%), Open Extravert (Profile 2, 42%), Competitive Neurotic (Profile 3, 17%), and Cooperative Perfectionist (Profile 4, 8%). Profiles 1, 3, and 4 showed similarly low levels of emotional stability, extraversion, and intellect but differed significantly in agreeableness and conscientiousness. Gender and country differences across athletes representing specific profiles were also noted. Profile 2 showed the strongest link with academic achievement. Hierarchical multiple linear regression showed that LPA profiles explained only 2% of GPA variance, compared to Big Five personality traits (9%) and demographic variables, such as sex, country, and study major (8%), which were also included in the following steps in the regression model, explaining only 9% and 8%, respectively. Most student athletes (52%) with personality profiles 1 (Restrained Neurotic), 3 (Competitive Neurotic), and 4 (Cooperative Perfectionist) may require psychological training to better cope with negative emotions and stress arising in competitive and academic settings. Profile 2 (Open Extravert) seems to be the most adaptive and potentially successful personality type. Personality types are, at least to some extent, related to gender and country of residence. More cross-cultural research is required to further verify the types of athletic personalities. Full article

Digital transformation has become important for SMEs that want better control, transparency, and coordinated operations. Yet, many studies treat digital tools in isolation and do not explain how AI and big data capabilities, together with process integration, drive governance outcomes. This gap limits a clear understanding of how digital transformation supports governance performance in SMEs. This study examines how digital transformation (DT) influences digital governance performance (DGP) in SMEs, with AI and big data analytical capability (AIBDAC) and process integration capability (PIC) as mediators. The research is grounded in the Resource-Based View, Dynamic Capabilities Theory, and the Technology Organization Environment framework. Data were collected from SMEs across five regions of Saudi Arabia using cluster and purposive sampling to target employees and managers involved in digital, analytical, and process integration work. A total of 396 valid responses were included in the analysis. Partial Least Squares Structural Equation Modelling (PLS SEM) was used to assess the measurement model, test the hypothesized paths, and evaluate mediation and moderation effects. The findings show that DT, AIBDAC, PIC, and top management support (TMS) have significant direct effects on DGP. AIBDAC and PIC act as key mediators, fully transmitting the effects of digital innovation capability and strategic readiness and partially mediating the effects of DT and TMS. Multi-group analysis shows that small and medium-large firms rely on different capability combinations. The study contributes by explaining how SMEs strengthen governance through capability development and offers practical guidance for improving governance through digital transformation. Full article

Big data analytics (BDA) has emerged as a crucial strategic asset for organizations aiming to enhance their sustainable company performance; nevertheless, empirical information elucidating the correlation between analytics and sustainability results is scarce, especially in developing nations. This study examines the influence of big data analytics (BDA) on sustainable firm performance (SFP) within the Libyan telecommunications sector, focusing on the mediating roles of organizational learning (OL) and process-oriented dynamic capabilities (PODCs), utilizing dynamic capability and organizational learning theories. A quantitative, cross-sectional research design was utilized. A systematic questionnaire was used to collect data from personnel at five different managerial and functional levels in the Libyan telecoms sector. There were 354 valid replies from a group of 5400 professionals who worked in the managerial, technical, and strategic areas. We used Partial Least Squares Structural Equation Modeling (PLS-SEM) with Smart PLS 4.0 to look at the proposed research model. We used measurement scales from previous investigations. The findings demonstrate that BDA exerts a positive and statistically significant influence on SFP. Nonetheless, this direct effect is quite minor when juxtaposed with the indirect effects conveyed by OL and PODCs. Both organizational learning and process-oriented dynamic capabilities significantly and partially mediate the relationship between big data analytics (BDA) and sustainable performance. This shows that analytics-driven sustainability outcomes depend heavily on a company’s ability to learn from data and change how it does things. This study enhances the Business and Management literature by elucidating the inadequacy of analytics investments in producing robust sustainability outcomes. It emphasizes the essential function of supplementary organizational capabilities in converting data-driven insights into enduring economic, environmental, and social value. From a practical standpoint, the findings indicate that managers and policymakers in developing economies ought to prioritize learning systems and adaptive process capabilities in conjunction with digital investments to fully harness the sustainability potential of big data analytics. Full article

Background. NOTCH receptors play a pivotal role in carcinogenesis. Upon ligand binding, a cascade of proteolytic cleavages mediated by ADAM proteases and the γ-secretase complex activates the receptor, ultimately releasing the NOTCH intracellular domain (NICD). NICD translocates to the nucleus, where it regulates gene expression. This review mainly aims to evaluate γ-secretase inhibitors (GSIs) as anticancer agents in preclinical and clinical settings, with a focus on their ability to block tumor progression, target cancer stem cells, and overcome resistance to standard therapies. Methods. A systematic search was conducted in the ISI Web of Science, PubMed, and Scopus databases, following PRISMA guidelines. The review included preclinical in vitro and in vivo studies, as well as clinical trials, investigating GSIs, either as monotherapy or in combination with other treatments, in TNBC, metastatic melanoma, PDAC, gastric cancer, and NSCLC. Exclusion criteria included duplicates, non-English articles, studies published before 2010, studies on non-cancer conditions, research unrelated to NOTCH signaling, and studies outside the selected cancer types. Overall, 69 articles were included and categorized into the five types of cancer analyzed (20 on NSCLC, 22 on TNBC, 11 on metastatic melanoma, 7 on GC, and 9 on PDAC). Of these, 60 studies corresponded to preclinical research in the types of cancer, and 9 studies corresponded to clinical trials in the types of cancer except for GC. Two independent authors screened and extracted relevant data, with disagreements resolved by the corresponding author. Findings were synthesized qualitatively across cancer types under study. Results. This review summarizes therapeutic advances involving GSIs in cancers driven by oncogenic NOTCH signaling, based on the 69 articles included. Preclinical studies show that GSIs synergize with chemotherapy and radiotherapy, particularly in NSCLC, melanoma, and TNBC, and block EMT, overcome therapeutic resistance, and improve prognosis. Commonly used GSIs include DAPT and RO4929097, which enhance the efficacy of agents, such as gemcitabine (PDAC), paclitaxel, osimertinib, erlotinib, and crizotinib (NSCLC), and 5-FU (gastric cancer, TNBC). Promising strategies include combining GSIs with SAHA, ATRA, CB-103, and other NOTCH signaling targeting molecules, either alone or with chemo- and radiotherapy. Clinical trials with GSIs, however, remain limited. RO4929097 is the most extensively tested GSI in clinical settings. PDAC trials combining GSIs with gemcitabine showed no benefit; melanoma trials yielded modest outcomes; and TNBC trials demonstrated partial responses to GSIs but overall low efficacy and significant adverse events. Discussion and Conclusions. Despite encouraging preclinical evidence, clinical trials with GSIs have underperformed, largely due to tumor heterogeneity, dosing limitations, and the non-selective nature of γ-secretase inhibition. Other NOTCH inhibitors, such as DLL4 antibodies, also resulted in partial responses and secondary effects. Future strategies should prioritize receptor-specific NOTCH inhibitors, patient stratification based on NOTCH pathway activation, and optimized combination regimens. Emerging approaches include integrating immunotherapy with advanced technologies such as CRISPR, CAR-T cells, and bispecific antibodies, as well as targeted delivery systems to enhance efficacy and reduce toxicity. Additional research directions include addressing the tumor microenvironment and EMT-driven resistance, elucidating the mechanisms of immune evasion, and inhibiting tumor angiogenesis. Finally, leveraging artificial intelligence and big-data-driven personalized medicine, including sex-specific considerations, will be essential for improving patient outcomes. Full article

With global urbanisation anticipated to reach 68% by 2050, there is a significant risk of exacerbating urban transport emissions. Urban transport decarbonisation is a complex adaptive system challenge, the understanding and optimisation of which could be supported by digital twins (DTs). Although prior research has explored digital and big data technology applications, creating actionable insights requires human-centred designs. We conducted a structured workshop to gather practitioner views on how urban-scale DTs can support transport decarbonisation. Specifically, we explored the outcomes they aim to achieve, the interventions they are interested in, and the value digital twinning offers compared to current methods. The data was synthesised and analysed to identify (1) impacts, (2) interventions, (3) location types, (4) data sources and (5) feedback mechanisms of importance to participants. These five aspects are proposed as a framework to support the definition of digital twinning use cases targeting urban transport decarbonisation. Application of the framework encourages creators to explicitly consider the services to be provided to users, how the derived insights influence the real world and the data connections between the physical and digital, noting that these are often overlooked in reported research. A framework application is illustrated through an example use case described for the West Midlands, UK. Full article

This study investigated an integrative mediation model examining whether anxiety and depression mediate the relationship between the Big Five personality traits and the severity of alcohol and nicotine dependence among psychiatric patients with neurotic disorders (ICD-10 codes F40–F48). A cross-sectional design was conducted on a clinical sample of 232 patients (57.3 female; mean age = 48.58, SD = 10.77) using standardized instruments: Big Five Inventory (BFI-44), Fagerström Test for Nicotine Dependence (FTND), Michigan Alcoholism Screening Test (MAST), and Depression, Anxiety, and Stress Scale (DASS-21). Data were analyzed using MLR mediation modeling. The model explained 32.6 of the variance in nicotine dependence and 27.1 in alcohol dependence. Results revealed a pattern of complete mediation: neuroticism had no direct effect on addiction but influenced alcohol dependence exclusively through anxiety (p = 0.001) and nicotine dependence through depressive symptoms (p = 0.012). Extraversion and agreeableness showed a dual role, exerting significant direct positive paths toward addiction severity (p = 0.005) while simultaneously reducing it through negative indirect effects on affective distress. Overall, neuroticism was confirmed as a universal risk factor for mental health issues. These findings suggest that personality-driven addiction in neurotic patients is operationalized through specific clinical symptoms, highlighting the necessity for therapeutic interventions focused on targeted affect regulation and social assertiveness to mitigate substance use in this population. Full article

Offshore and deep-sea aquaculture is increasingly recognized as a key pathway for expanding marine food production as nearshore resources decline and global demand for high-quality aquatic products grows. However, open-ocean farming operates under highly dynamic environmental conditions and long production cycles, which impose significant challenges on conventional experience-based management. This review synthesizes recent research on informatized management in offshore and deep-sea aquaculture and proposes a structured management framework based on five functional layers: perception, transmission, platform, decision, and execution. By systematically analyzing environmental constraints, technical bottlenecks, and management requirements, this framework integrates key technologies including the Internet of Things, unmanned surface and underwater vehicles, big data analytics, and artificial intelligence. The review further examines representative application scenarios, including environmental monitoring and early warning, intelligent feeding and nutrition management, disease prevention and control, and remote monitoring and management. Through cross-study comparison, this work highlights current limitations in system integration and long-term validation, while clarifying the technological pathways required for scalable and reliable offshore deployment. Overall, this review provides a conceptual foundation and technical reference for improving operational safety, production efficiency, and environmental sustainability in offshore and deep-sea aquaculture. Full article

With the rapid development of genomic big data and genome-wide association study technologies, massive genomic data are available for the genetic dissection, development and utilization of important economic traits. Various GWAS algorithms have become increasingly efficient, enabling high-performance processing of these massive datasets. This has made it possible to conduct genetic dissection of economic traits based on big data and advanced statistical methods, which will provide accurate target loci for future trait improvement and genetic manipulation, greatly accelerating the process of genetic breeding. In this study, genotyping of 426 fish was performed using the T7 sequencing platform and 555,242 SNPs distributed across all the chromosomes were screened by data cleaning. We compared the performance of two GWAS methods, GCTA and GEMMA, in both single-trait and multi-trait frameworks. Twenty-nine SNPs significantly associated with seven traits were identified through single and multi-trait combined GWAS. Single-trait GWAS analysis using GCTA identified 1047 and 1452 significant loci for six growth traits and one sex trait (phenotypic sex, male or female) respectively, ultimately revealing 10 candidate genes, including slc48a1a, filip1L, nedd9, Crebbpa, LOC134024622, zbtb18, LOC117378376, LOC131530706, syde2, and col24a1. Similarly, 671 and 642 significant SNPs were detected with GEMMA for single-trait GWAS associated with six growth traits and the sex trait, respectively. In total, 16 candidate genes were mapped for these seven traits. Multi-trait GWAS was also performed using GEMMA for the six growth traits (sex was included as a covariate). The traits were grouped into five combinations based on their genetic correlations. A total of 37 SNPs were identified, corresponding to 10 candidate genes: LOC131530706, LOC134022516, abat, maml3, cica, LOC124013321, slc25a12, dnah10, syt9a, and LOC136932979. Notably, five overlapping candidate genes (LOC131530706, LOC134022516, abat, slc25a12 and dnah10) were also identified in both single- and multi-trait GWAS methods of GEMMA, highlighting their genetic stability and significance. The two GWAS methods, GCTA and GEMMA, identified two genes that were the same. The results of this study provide molecular markers and genetic resources for the improvement of growth traits in Plecoglossus altivelis. Full article